DACH1在舌鳞状细胞癌及舌不典型增生中的表达及意义

doi:10.19439/j.sjos.2017.01.013

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (1): 64-68.doi: 10.19439/j.sjos.2017.01.013

DACH1在舌鳞状细胞癌及舌不典型增生中的表达及意义

张丽^*, 刘芬^*, 项锋钢, 王成勤

青岛大学附属医院病理科,山东青岛 266003

收稿日期:2016-04-08 修回日期:2016-07-10 出版日期:2017-02-25 发布日期:2017-03-20
通讯作者: 项锋钢,E-mail：xiangfenggang@163.com;
作者简介:张丽（1984-）,女,硕士,E-mail：gummymyf@163.com; 刘芬（1990-）,女,硕士,E-mail：wfkerry09@163.com。*并列第一作者
基金资助:
国家自然科学基金（81202142）

Expression and significance of human Dachshund homolog 1 in tongue squamous cell carcinoma and tongue atypical hyperplasia

ZHANG Li, LIU Fen, XIANG Feng-gang, WANG Cheng-qin

Department of Pathology, Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China

Received:2016-04-08 Revised:2016-07-10 Online:2017-02-25 Published:2017-03-20

摘要/Abstract

摘要： 目的探讨细胞命运决定因子（Dachshund homolog 1,DACH1)蛋白在舌鳞状细胞癌发生、发展及预后中的作用。方法应用免疫组织化学方法检测51例舌鳞状细胞癌及其对应癌周正常组织、25例舌不典型增生组织中DACH1的表达。采用SPSS16.0软件包进行统计学处理。结果 51例舌鳞状细胞癌中,36例（70.6%）DACH1表达显著低于癌周正常组织（P<0.05）;DACH1低表达与肿瘤分化差、临床分期晚及淋巴结转移相关;DACH1在舌不典型增生中的表达显著低于舌鳞癌组织（P<0.05）。单因素生存分析显示,DACH1高表达的舌癌患者,总体生存率显著高于低表达组（P<0.05）。结论 DACH1表达降低可能与舌鳞状细胞癌的发生、发展及不良预后有关,可能有助于舌癌前病变的辅助判断,并为肿瘤治疗提供潜在靶点。

关键词: 细胞命运决定因子, 鳞状细胞癌, 不典型增生

Abstract: PURPOSE: To investigate the expression and role of human Dachshund homolog1(DACH1)in the development and prognosis of tongue squamous cell carcinoma(TSCC). METHODS: The expression of DACH1 was detected immunohistochemistrically in 51 samples of paraffin-embedded TSCC, paired adjacent tissues and 25 samples of atypical hyperplasia tissues of the tongue. Statistical analysis was performed using SPSS 16.0 software package. RESULTS: The results showed that 36 out of 51 TSCCs (70.6%) expressed lower levels of DACH1 compared with the paired adjacent tissues. Moreover, there was significant differences in expression of DACH1 between TSCC and paired adjacent tissues (P<0.05), and lower expression was associated with poor differentiation of tumors, advanced clinical stage and lymph node metastasis(P<0.05).In addition, the expression level of DACH1 in atypical hyperplasia tissues of tongue was also significantly lower than in tumors(P<0.05). Univariate survival analysis showed that the overall survival rate of patients with high expression of DACH1 was significantly higher than those with low expression of DACH1 (P<0.05). CONCLUSIONS: The decreased expression of DACH1 may be related to occurrence, development and poor prognosis of TSCC. It may contribute to making diagnosis for precancerous lesions in the tongue, and provide a potential effective therapeutic target for TSCC.

Key words: Dachshund homolog1, Squamous cell carcinoma, Atypical hyperplasia

中图分类号:

R365

张丽, 刘芬, 项锋钢, 王成勤. DACH1在舌鳞状细胞癌及舌不典型增生中的表达及意义[J]. 上海口腔医学, 2017, 26(1): 64-68.

ZHANG Li, LIU Fen, XIANG Feng-gang, WANG Cheng-qin. Expression and significance of human Dachshund homolog 1 in tongue squamous cell carcinoma and tongue atypical hyperplasia[J]. Shanghai Journal of Stomatology, 2017, 26(1): 64-68.

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DACH1在舌鳞状细胞癌及舌不典型增生中的表达及意义

Expression and significance of human Dachshund homolog 1 in tongue squamous cell carcinoma and tongue atypical hyperplasia

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