上海口腔医学

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (4): 415-418.doi: 10.19439/j.sjos.2018.04.016

• 论著 • 上一篇    下一篇

YAP、TAZ蛋白在口腔鳞状细胞癌中的表达及意义

涂敏松1, 李逸松2, 张雄1   

  1. 1.杭州市第一人民医院 口腔颌面外科, 浙江 杭州 310003;
    2.昆明医科大学附属第一医院 整形外科,云南 昆明 650031
  • 收稿日期:2017-11-24 修回日期:2018-03-06 出版日期:2018-08-25 发布日期:2018-10-09
  • 通讯作者: 涂敏松,E-mail: tuminsong@qq.com
  • 作者简介:涂敏松（1985-）,男,硕士,主治医师

Expression and significance of YAP and TAZ proteins in oral squamous cell carcinoma

TU Min-song1, LI Yi-song2, ZHANG Xiong1   

  1. 1.Department of Oral and Maxillofacial Surgery, Hangzhou First People's Hospital. Hangzhou 310003, Zhejiang Province;
    2.Department of Plastic and Reconstructive Surgery,The First Affiliated Hospital of Kunming Medical University. Kunming 650031, Yunnan Province, China
  • Received:2017-11-24 Revised:2018-03-06 Online:2018-08-25 Published:2018-10-09

PDF (PC)

137

摘要： 目的: 探讨YAP、TAZ蛋白在口腔鳞状细胞癌中的表达及意义。方法: 选取2014年2月—2017年3月保存的口腔鳞状细胞癌组织标本113例,选取癌旁组织（距癌组织>2 cm）作为对照,采用免疫组织化学染色法检测YAP和TAZ蛋白的表达,比较其与临床病理特征的关系。采用SPSS 19.0软件包对数据进行统计学分析。结果: 癌组织YAP和TAZ蛋白阳性表达率分别为65.49%和61.95%,显著高于癌旁组织（P<0.05）;中低分化、有淋巴结转移、临床Ⅲ期、肿瘤直径>4 cm的患者,YAP蛋白阳性表达率分别为83.64%、80.33%、82.35%和82.61%,显著高于高分化、无淋巴结转移、临床Ⅰ~Ⅱ期、肿瘤直径≤4 cm的患者（P<0.05）;中低分化、临床Ⅲ期、肿瘤直径>4 cm的患者,TAZ蛋白阳性表达率分别为80.00%、85.29%和82.61%,显著高于高分化、临床Ⅰ~Ⅱ期、肿瘤直径≤4 cm的患者（P<0.05）;YAP蛋白与TAZ蛋白表达呈正相关（rs=0.571,P<0.05）。结论: YAP和TAZ蛋白在口腔鳞状细胞癌中呈高表达,与肿瘤分化程度、肿瘤直径等临床病理特征有关,提示Hippo信号通路可能参与了口腔鳞状细胞癌的发生与发展。

关键词: 口腔鳞状细胞癌, YAP蛋白, TAZ蛋白, Hippo信号通路

Abstract: PURPOSE: To investigate the expression and significance of YAP and TAZ proteins in oral squamous cell carcinoma. METHODS: From February 2014 to March 2017, 113 oral squamous cell carcinoma specimens were selected, and the adjacent tissues (away from carcinoma > 2 cm) were selected as the control. Immunohistochemical staining was used to detect the expression of YAP and TAZ protein, and its relationship with clinicopathological features were evaluated with SPSS 19.0 software package. RESULTS: The positive rate of YAP and TAZ protein in cancer tissues was 65.49% and 61.95%, respectively, which was significantly higher than that in the adjacent tissues (P<0.05). The positive expression of YAP protein in patients with low differentiation, cervical lymph node metastasis, stage Ⅲ, tumor diameter> 4 cm were 83.64%, 80.33%, 82.35% and 82.61%, significantly higher than that inpatients with high differentiation, without cervical lymph node metastasis, stage I-II, tumor diameter ≤4 cm (P<0.05). The positive expression rate of TAZ protein in patients with low differentiation, stage III, tumor diameter >4 cm was 80%, 85.29% and 82.61%, significantly higher than that in patients with high differentiation, stage I-II, tumor diameter ≤4 cm (P<0.05). The expression of YAP protein was positively correlated with the expression of TAZ protein (rs=0.571, P<0.05). CONCLUSIONS: YAP and TAZ proteins are strongly expressed in oral squamous cell carcinoma, closely related to the clinical and pathological features such as the degree of differentiation and the diameter of the tumor, suggesting that Hippo signaling pathway may be involved in the development of oral squamous cell carcinoma.

Key words: Oral squamous cell carcinoma, YAP protein, TAZ protein, Hippo signaling pathway

中图分类号: