Effect of oral implant restoration on dentition defect patients and its impact on TNF-α and IL-6 levels in gingival crevicular fluid

doi:10.19439/j.sjos.2020.02.020

Abstract

Abstract: PURPOSE: To investigate the clinical effects of oral implant restoration in patients with dentition defects and the its impact on tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels in gingival crevicular fluid. METHODS: Eighty-four patients with dentition defects from May 2017 to August 1919 in People's Hospital of Shanghai Pudong District were enrolled and randomly divided into control group (n=42) and experimental group (n=42). Patients in the control group were repaired by routine methods,while those in the experimental group were treated with oral implant restoration. The effect of restoration was evaluated 6 months after treatment. The levels of TNF-α, IL-6 in the gingival crevicular fluid and dental function were compared between the 2 groups. The data were analyzed using SPSS 18.0 software package. RESULTS: The levels of TNF-α and IL-6 in the experimental group and the control group after treatment were significantly higher than those before treatment (P<0.05). The levels of TNF-α and IL-6 in the experimental group were significantly lower than those in the control group 6 months after treatment (P<0.05). The scores of dental function in the experimental group and the control group were significantly higher than those before treatment (P<0.05). The scores of retention, speech, chewing and aesthetics of the experimental group 6 months after treatment were significantly higher than the control group (P<0.05). The incidence of infection, pricking, post and core loosing and teeth missing in the experimental group was significantly lower than that of the control group (P<0.05). CONCLUSIONS: In the treatment of patients with dentition defects, implant restoration has little effect on the levels of TNF-α and IL-6 in gingival crevicular fluid, which is helpful to improve dental function and reduce the incidence of postoperative complications. Therefore, it is worthwhile to be popularized in clinical application.

Key words: Oral implant restoration, Dentition defect, Gingival crevicular fluid, Tumor necrosis factor-α, Interleukin-6

CLC Number:

R782.1

CHANG Zhong-fu, JIANG Dan-dan, ZHANG Zhi-rong, CAI Jian-ying. Effect of oral implant restoration on dentition defect patients and its impact on TNF-α and IL-6 levels in gingival crevicular fluid[J]. Shanghai Journal of Stomatology, 2020, 29(2): 217-220.

References

[1] 刘斐. 纯钛支架义齿的修复效果及对牙周病患者龈沟液中超敏C反应蛋白肿瘤坏死因子α水平的影响[J]. 中国药物与临床, 2018, 18(3): 345-346.
[2] 彭斌, 罗耀鹏, 梁培慧. 自锁托槽矫正技术在正畸患者中的应用及对龈沟液内IL-1β、TNF-α水平的影响研究[J].中国中西医结合耳鼻咽喉科杂志, 2018, 26(5): 50-53.
[3] Cecchinato D, Marino M, Lindhe J.Bone loss at implants and teeth in the same segment of the dentition in partially dentate subjects[J]. Clin Oral Implants Res, 2017, 28(5):626-630.
[4] 郭斌, 孙雷, 翟晓红. 氧化锆全瓷全冠修复对龈沟液患者的临床疗效观察[J].河北医学, 2017, 23(10): 1632-1636.
[5] 黄增, 喻红. 牙周炎对口腔种植修复患者牙周指数及种植体松动度的影响[J].宁夏医科大学学报, 2017, 39(9): 131-134.
[6] 但洪平, 罗毅, 杨随兴. 百强固位纤维用于前牙外伤的效果及对牙龈指数和龈沟出血指数的影响[J].成都医学院学报, 2017, 12(5): 601-604.
[7] Guarnieri R, Ippoliti S.Restoration of periodontally compromised dentitions using telescopic full-arch retrievable prosthesis supported by tooth-implant combination: a long-term retrospective study[J]. Int J Periodontics Restorative Dent, 2018, 38(2): 217-224.
[8] 孙玉刚, 陈延花, 王琳, 等. 青少年正畸治疗患者牙龈卟啉单胞菌及其毒力因子FimA基因型的变化研究[J]. 牙体牙髓牙周病学杂志, 2017, 27(12): 684-688.
[9] 吴家嘉. 石麦清火汤含漱辅助活性银离子抗菌液治疗慢性牙龈炎疗效及对EA、GRP78、CHOP水平的影响[J]. 现代中西医结合杂志, 2019, 28(9): 53-55.
[10] 曹伟靖, 张乐, 杜莉, 等. 纳米复合树脂和光固化复合树脂材料用于前牙美容修复的对比研究[J].现代生物医学进展, 2017, 17(31): 6149-6153.
[11] Koubi S, Gurel G, Margossian P, et al.A simplified approach for restoration of worn dentition using the full mock-up concept: clinical case reports[J]. Int J Periodontics Restorative Dent, 2018, 38(2):189-197.
[12] 于钦, 陈贤. 牙周炎患者基础治疗前后唾液和龈沟液中IL-6、TNF-α、MMP-8水平的变化[J]. 北京口腔医学, 2018, 26(6): 336-339.
[13] 韦彦锋, 刘艳春, 白琴, 等. 口腔种植修复与常规修复对牙列缺损患者的治疗效果及预后影响[J]. 临床和实验医学杂志, 2017, 16(21): 2171-2173.
[14] 潘磊, 沈宏一, 郑伶俐, 等. 口腔种植修复与常规修复对牙列缺失患者生活质量及龈沟液细胞因子水平的影响[J]. 现代生物医学进展, 2018, 18(6): 1141-1145.
[15] 范亚伟, 孙福星, 张鹏飞. 数字化技术在口腔上前牙区种植修复中的临床研究[J]. 山西医科大学学报, 2018, 49(7): 126-129.