Correlation between nutritional status before radiotherapy and dietary intake in patients with oral cancers

doi:10.19439/j.sjos.2019.03.013

Abstract

Abstract: PURPOSE: To explore the correlation between dietary nutrient intake and PG-SGA score in patients with oral cancers before radiotherapy. Methods: Sixty-five patients with oral cancers treated in Shanghai Ninth People's Hospital were selected. The 72-hour dietary survey method was used to understand the food intake of the patients. PG-SGA was used to make quantitative scoring of the nutritional status of the patients. SPSS 23.0 software package was used for data analysis. Results: The number of severe malnutrition cases in male patients was significantly higher than that in female patients (P<0.05). Energy, fat and fat energy ratio, carbohydrate and carbohydrate energy ratio from diet in good nutrition/mild malnutrition group, moderate malnutrition, severe malnutrition patients were over reference intake of dietary nutrients for Chinese residents; protein intake and protein energy ratio were greater than reference intake of nutrients for Chinese people. There was no significant difference among the three groups. The selenium intake of the well-nourished/mildly malnourished, moderately malnourished and severely malnourished groups was 67.15, 81.04 and 81.59 μg; vitamin E was 27.81, 30.88, 26.40 mg α-TE; vitamin C was 150.19, 159.81, 183.71 mg; retinol was 904.65, 1401.51, and 1373.81 μg RAE, respectively. Niacin was 12.97, 18.76 and 14.27 mg NE, respectively, reaching or exceeding the reference intake. There was no significant difference among the three groups. In male patients, dietary energy and niacin intake were negatively correlated with PG-SGA score (P<0.05). Conclusions: Patients with oral cancers have a high incidence of malnutrition before radiotherapy, and the average intake of dietary energy, protein, fat, carbohydrates and micronutrients such as selenium, vitamin E, vitamin C, retinol and niacin reached or exceeded the reference intake. Energy and niacin intake were negatively correlated with PG-SGA score in male patients.

Key words: Oral cancers, 72h dietary survey, Dietary nutrients, PG-SGA score

CLC Number:

R739.8

ZHANG Hai-feng, ZHANG Mei-fang, ZHAO An-da, LI Rong-rong. Correlation between nutritional status before radiotherapy and dietary intake in patients with oral cancers[J]. Shanghai Journal of Stomatology, 2019, 28(3): 288-292.

References

[1] 郑家伟, 钟来平, 张志愿, 等.口腔癌的预防[J]. 中国口腔颌面外科杂志, 2009, 7(2): 168-175.
[2] Parkin DM, Läärä E, Muir CS.Estimates of the worldwide frequency of sixteen major cancers in 1980[J].Int J Cancer. 1988, 41(2): 184-197.
[3] 王祥军. 1447例口腔颌面部恶性肿瘤临床病理分析 [D]. 郑州: 郑州大学, 2012.
[4] Chasen MR, Bhargava R.A descriptive review of the factors contributing to nutritional compromise in patients with head and neck cancer[J]. Support Care Cancer, 2009, 17(11): 1345-1351.
[5] 王剑锋, 方芳, 于雷. 营养干预对头颈部肿瘤急性放射性口腔黏膜反应的影响[J]. 肠外与肠内营养, 2018, 25(1): 28-31.
[6] 史双, 王艳莉, 方玉, 等. 头颈部肿瘤放疗患者营养状况与生活质量的相关性研究[J].护理管理杂志, 2016, 16(11): 789-791.
[7] 任杰, 袁志, 张欣平, 等. 头颈部肿瘤患者放疗期间营养状况与生活质量现状及两者相关性分析[J]. 解放军医药杂志, 2018, 30(7): 18-21.
[8] 郝洁, 韩加. 头颈部肿瘤患者放疗期间营养状况影响因素分析[J]. 医药前沿, 2015, 5(31): 131-132.
[9] 康文星, 党亚正, 黄世高, 等. 营养干预对头颈部肿瘤患者放射治疗后生活质量的影响[J]. 西部医学, 2016, 28(9): 1246-1249.
[10] Ottery FD.Rethinking nutritional support of the cancer patient: the new field of nutritional oncology[J]. Semin Oncol, 1994, 21(6): 770-778.
[11] 中国抗癌协会肿瘤营养与支持治疗专业委员会组织. 中国肿瘤营养治疗指南[M]. 北京: 人民卫生出版社, 2015.
[12] 邓明辉. 湖南地区口腔颌面部恶性肿瘤发病情况调查分析[D]. 长沙: 中南大学, 2009.
[13] Calder PC.Immunonutrition[J].BMJ, 2003, 327(7407): 117-118.
[14] Stableforth WD, Thomas S, Lewis SJ.A systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer[J]. Int J Oral Maxillofac Surg, 2009, 38(2): 103-110.
[15] Moskovitz DN, Kim YI.Does perioperative immunonutrition reduce postoperative complications in patients with gastrointestinal cancer undergoing operations?[J]. Nutr Rev, 2004, 62(11): 443-447.
[16] 中国抗癌协会头颈肿瘤专业委员会. 头颈部肿瘤综合治疗专家共识[J].中华耳鼻咽喉头颈外科杂志, 2010, 45(7): 535-541.
[17] 中华医学会肠外肠内营养学分会. 肿瘤患者营养支持指南[J]. 中华外科杂志, 2017, 55(11): 801-829.
[18] Combs GF Jr.Selenium in global food systems[J]. Br J Nutr, 2001, 85(5): 517-547.
[19] Carey AM, Lombi E, Donner E, et al.A review of recent developments in the speciation and location of arsenic and selenium in rice grain[J].Anal Bioanal Chem, 2012, 402(10): 3275-3286.
[20] 孙国平, 潘跃银, 孙昕, 等. 微量元素铜、锌、硒与恶性肿瘤的关系探讨[J].安徽医科大学学报, 2002, 37(5): 380-382.
[21] 李军袖, 郭朝瑞, 封帆, 等. 维生素C在肿瘤治疗中的研究概况[J]. 海峡药学, 2016, 28(9): 1-4.
[22] 郑美莲, 毛志达, 黄惠英, 等. 维生素A、E对放射治疗鼻咽癌患者抗氧化水平的影响[J].营养学报, 2005, 27(2): 169-170.
[23] 李若虹, 吕景晶, 白彦萍, 等. 烟酸缺乏症的临床及研究现状[J]. 实用皮肤病学杂志, 2012, 5(4): 218-220.
[24] Santolla MF, De Francesco EM, Lappano R, et al.Niacin activates the G protein estrogen receptor (GPER)-mediated signalling[J].Cell Signal, 2014, 26(7): 1466-1475.
[25] Bermudez Y, Benavente CA, Meyer RG, et al.Nicotinic acid receptor abnormalities in Human skin cancer: Implications for a role in epidermal differentiation[J]. PLoS One, 2011, 6(5): e20487.