Related factors of cervical lymph node metastasis, prognosis of patients with cN0tongue squamous cell carcinoma

doi:10.19439/j.sjos.2022.05.017

Abstract

Abstract: PURPOSE: To explore the related factors of cervical lymph node metastasis and postoperative quality of life in patients with cN0 tongue squamous cell carcinoma (SCC), and provide a theoretical basis for clinical prediction of occult neck metastasis and improvement of survival rate. METHODS: A total of 283 patients with cN0 tongue SCC who underwent surgery in Huaian No.1 People’s Hospital were collected. Chi-square test and logistic regression were used to analyze the correlation between cervical lymph node metastasis and clinical pathological parameters of patients. Single-factor and multi-factor Cox regression analysis were used to explore independent risk factors for prognosis of patients with tongue SCC. Survival analysis was used to study the correlation between cervical lymph node metastasis and prognosis of patients. SPSS 21.0 software package was used for statistical analysis. RESULTS: Chi-square test and logistic regression analysis showed that infiltration depth, T stage and pathological grade were closely related to cervical lymph node metastasis(P<0.05), and infiltration depth was the main factor leading to postoperative cervical lymph node metastasis(OR=2.175). The depth of invasion, pathological grade and cervical lymph node metastasis could be regarded as independent risk factor affecting the prognosis of patients with tongue SCC(P<0.05). CONCLUSIONS: Invasion depth, T stage and pathological grade can be used as indicators to predict occult cervical lymph node metastasis in patients with cN0 tongue SCC. Invasion depth, pathological grade and cervical lymph node metastasis can be used as independent indicators to predict the prognosis of patients with cN0 tongue SCC.

Key words: Tongue squamous cell carcinoma, Occult metastasis, Invasion depth, Prognosis

CLC Number:

R739.8

YE Pu, HUANG Xing-hong, ZHANG Wei, WU Meng, YU Hui-ming. Related factors of cervical lymph node metastasis, prognosis of patients with cN0tongue squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2022, 31(5): 540-543.

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