The relationship between periodontitis and arterial sclerosis without genetic confounding

doi:10.19439/j.sjos.2017.02.017

Abstract

Abstract: PURPOSES: The aim of this study was to evaluate periodontitis as a significant risk factor related to arterial sclerosis after eliminating genetic confounding. METHODS: Fifty two monozygotic twin pairs, 104 patients, were divided into 3 groups. group A: 24 pairs, 48 healthy people, as the blank group; group B: 28 patients with periodontitis, as the control group; group C: 28 patients with periodontitis, as the treatment group. The sample in group B and C had the same gene type. The index of CRP, IL-6, TNF-αand IMT were detected before treatment, 6 and 12 week after treatment. The data were analyzed using SPSS 17.0 software package. RESULTS: The index of CRP, IL-6, TNF-α and IMT decreased after treatment in group C, there was no significant change in group A and B at each check point. CONCLUSIONS: Periodontitis can promote the development of sclerosis without the intervening of gene.

Key words: Gene type, Periodontitis, Sclerosis, Periodontal treatment, Monozygotic twins

CLC Number:

R781.4

HAN Ya-kun, LIN Xiao-ping. The relationship between periodontitis and arterial sclerosis without genetic confounding[J]. Shanghai Journal of Stomatology, 2017, 26(2): 209-212.

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