Expression of B cell activation factor and correlation analysis in patients of systemic lupus erythematosus and its correlation with periodontitis

doi:10.19439/j.sjos.2022.02.012

Abstract

Abstract: PURPOSE: To detect the level of B cell activating factor (B - cell activating factor of the TNF family, BAFF) in the serum of patientes suffering from systemic lupus erythematosus (SLE) with periodontitis, and analyze the relationship between the expression of BAFF with periodontitis and SLE. METHODS: According to the inclusion criteria, patients visiting the Department of Stomatology and Rheumatology, Shengjing Hospital Affiliated to China Medical University were selected, including 19 patients in the periodontitis group(P group), 22 in the systemic lupus erythematosus group (SLE group), 24 in the systemic lupus erythematosus combined with periodontitis group(SLE+P group), and 20 in the healthy control group(H group). The general information, periodontal probing depth (PD), clinical attachment loss (CAL), gingival sulcus bleeding index(SBI) were collected. Serum samples of patients in each group were collected, and BAFF content was determined by Elisa. Rheumatic and immunological indexes of subjects in SLE group and SLE+P group were determined, and the correlation between BAFF content and periodontal indexes was analyzed. SPSS 20.0 software package was used for statistical analysis. RESULTS: CAL in P+SLE group was significantly higher than that in P group(P<0.05). Serum BAFF concentrations in SLE+P group, SLE group and P group were significantly higher than those in the healthy control group (P<0.05). Serum BAFF concentration in SLE+P group was significantly higher than that in SLE group(P<0.05). ESR, SLEDAI and disease duration in SLE+P group were significantly higher than those in SLE group (P<0.05). The expression level of BAFF in serum was positively correlated with CAL and SBI(P<0.01). The expression level of BAFF in serum was positively correlated with PD(P<0.05). There was significant positive correlation between serum BAFF level and duration of disease and hormone use(P<0.01). Serum BAFF level was positively correlated with C3 (P<0.05). CONCLUSIONS: SLE has certain correlation with periodontitis, and serum BAFF in SLE patients with periodontitis is significantly increased.BAFF may be associated with the development of SLE and periodontitis.

Key words: Periodontitis, Systemic lupus erythematosus, B cell activation factor, Activity index of systemic lupus erythematosus

CLC Number:

R781.4

ZHANG Li-mu, WANG Ye, QI Shuai, LIN Xiao-ping. Expression of B cell activation factor and correlation analysis in patients of systemic lupus erythematosus and its correlation with periodontitis[J]. Shanghai Journal of Stomatology, 2022, 31(2): 178-183.

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