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Shanghai Journal of Stomatology    2008, 17 (4): 380-392.   Abstract （109）      PDF （547KB）（2529）       Knowledge map    Related Articles | Metrics

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Shanghai Journal of Stomatology    2011, 20 (1): 31-35.   Abstract （76）      PDF （921KB）（577）       Knowledge map    Related Articles | Metrics

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Shanghai Journal of Stomatology    2010, 19 (3): 253-254.   Abstract （82）      PDF （413KB）（443）       Knowledge map    Related Articles | Metrics

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Experts consensus on diagnostic and therapeutic strategies for malocclusions at early developing stage FANG Bing, JIN Zuo-lin, BAI Yu-xing, WANG Lin, ZHAO Zhi-he, LI Wei-ran, BAI Ding, HE Hong, LIU Yue-hua, HU Min, SONG Jin-lin, CHEN Li-li, CAO Yang, WU Ting-xi, LI Song, LI Huang, SHI Jie-jun, CHU Feng-ting Shanghai Journal of Stomatology    2021, 30 (5): 449-455.   DOI: 10.19439/j.sjos.2021.05.001 Abstract （726）      PDF （861KB）（1045）       Knowledge map    Early orthodontic intervention remains a controversial notion in current dental care regime. Whilst early orthodontic treatment for children is the province for orthodontic specialists, a growing number of general practitioners, who may not possess sufficient specialty knowledge, are also involved, raising the concerns about the propriety and quality of their treatment modalities. However, orofacial development of children and adolescents is in a very complicated environment. Comprehensive theoretical knowledge and a great wealth of practical experience are required to ensure the final treatment effect. The possible complications should be kept under control and fully informed to patients and their parents. In order to unify and standardize early orthodontic treatment protocol and help to promote healthy and orderly development of early orthodontic treatment, this consensus summarized the practical experience of orthodontic experts from many famous colleges and affiliated hospitals for clinical reference. Reference | Related Articles | Metrics

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Classification for mandibular deviation and facial asymmetry and its clinical significance SHEN Gang Shanghai Journal of Stomatology    2021, 30 (1): 1-6.   DOI: 10.19439/j.sjos.2021.01.001 Abstract （1266）      PDF （4956KB）（955）       Knowledge map    Judged from the clinical manifestations, etiological mechanisms and jaw morphological structures, malocclusions with mandibular deviation and facial asymmetry are classified into three main categories, i.e., those with mandibular positioning factors, those with mandibular condyle defects, and those with jaw congenital deformities. In the first category, three subtypes, including mandibular rotation caused by dentitional irregularities, by dental compensation and by habitual posturing, are further defined. In the second category, mandibular deviation caused by condylar asymmetrical resorption or hyperplasia are defined as the two subtypes. The third category is further divided into two subtypes, i.e., jaw and facial asymmetry resulting from maxillary or mandibular structural deformities. The prime goal of orthodontic therapy is to displace and restore the deviated mandible to its right position, followed by correction of occlusal intercuspation. As an important procedure of the whole treatment protocol, It is critical to detect and localize the correct mandibular position by manipulation and then register it by wax pattern and articulator transferring. For the cases with mandibular functional elements and condylar asymmetrical length, the treatment modalities include orthopedic repositioning of the mandible by using occlusal and bite plane, SGTB and SGHB therapies; for cases with growth and developmental anomalies, orthognathic intervention should be an optimal solution. Reference | Related Articles | Metrics

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Dentists' knowledge and practice of revascularization in Shanghai: a cross-sectional study XIAO Wen, CHEN Xi, WANG Jun Shanghai Journal of Stomatology    2018, 27 (4): 390-395.   DOI: 10.19439/j.sjos.2018.04.011 Abstract （242）      PDF （3771KB）（235）       Knowledge map    PURPOSE: To evaluate dentists' knowledge and practice of revascularization in Shanghai. METHODS: Using multistage, cluster and random sampling method, 5 districts from Shanghai urban and suburban areas were randomly selected, covering class-three and class-two hospitals, dental center, private hospitals and clinics, and 3 class-three authoritative dental special hospitals (nonrandom). A questionnaire survey was conducted among the endodontists, pedodontists and general dentists. SAS 9.13 software package was used for data analysis. RESULTS: A total of 834 dentists were investigated, and 588 valid questionnaires (75.3%) were collected. 401 (68.2%) dentists were familiar with revascularization, 20% of them treated patients with revascularization. The most common source of learning revascularization was continuing dental education (33.3%) and 85.8% dentists showed interest in revascularization. The most important reason for not using revascularization was unfamiliar with the operational procedure (41.5%). CONCLUSIONS: The middle-aged endodontic and pediatric specialists with higher education have better understanding and motion to apply revascularization, and are more interested in continuing dental education. In continuing education courses, lectures of revascularization with practical training should be increased, in order to promote revascularization application in dental practice. Reference | Related Articles | Metrics

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Evaluation of the effect of digital crown extension guide in aesthetic restoration of anterior teeth WANG Xue-chun, WANG Yong, XU Xiao-bo, HAO Xin-he Shanghai Journal of Stomatology    2022, 31 (3): 260-264.   DOI: 10.19439/j.sjos.2022.03.007 Abstract （312）      PDF （749KB）（357）       Knowledge map    PURPOSE: To evaluate the clinical effect of three-dimensional digital smile design (3D-DSD) combined with double positioning crown extension guide in aesthetic restoration of anterior teeth. METHODS: Twenty patients who needed aesthetic crown lengthening and full crown restoration of upper anterior teeth were selected and randomly divided into the experimental group and control group, with 10 cases in each group. The experimental group carried out 3D-DSD, after confirming the plan, 3D printed double positioning crown extension guides were used to guide aesthetic crown lengthening, and full crown was completed 3 months after operation. The control group used traditional aesthetic crown lengthening and full crown restoration. PES/WES evaluation was performed before operation, three months and six months after operation. Visual analogue scales(VAS) were used to evaluate patient satisfaction 6 and 7 months after surgery, and the repeatability evaluation of VAS was conducted. The correlation between PES/WES score and overall satisfaction was analyzed 6 months after operation. SPSS 23.0 software package was used for statistical analysis. RESULTS: The PES/WES scores of the two groups of patients at 3 months and 6 months after operation were higher than those before operation(P<0.05). The two groups showed that the scores of the experimental group were significantly higher than those of the control group for PES 3 months after operation, PES and WES 6 months after operation(P<0.05).Satisfaction survey results showed that the intra-group correlation coefficient of the two VAS results was 0.956(P<0.05),and crown length-to-width ratio, smile curve, personality characteristics, patient participation and overall satisfaction in the experimental group were better than those of the control group(P<0.05).The results of Speraman correlation analysis showed that PES and WES scores at 6 months after operation were positively correlated with overall satisfaction (rs1=0.905, P<0.001; rs2=0.460, P=0.041). CONCLUSIONS: 3D digital smile design combined with double positioning crown extension guide guides the anterior aesthetic crown lengthening and restoration treatment, which can improve the effect of pink and white aesthetics after treatment and patient satisfaction. Reference | Related Articles | Metrics

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Shanghai Journal of Stomatology    2009, 18 (6): 667-668.   Abstract （77）      PDF （409KB）（248）       Knowledge map    Related Articles | Metrics

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Shanghai Journal of Stomatology    2011, 20 (4): 417-419.   Abstract （81）      PDF （543KB）（318）       Knowledge map    Related Articles | Metrics

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Effect of iRoot BP Plus on biological behavior of deciduous tooth pulp stem cells and human pulp stem cells WANG Jing, FANGTENG Jiao-zi, LIU He Shanghai Journal of Stomatology    2019, 28 (3): 251-258.   DOI: 10.19439/j.sjos.2019.03.006 Abstract （364）      PDF （6551KB）（406）       Knowledge map    PURPOSE: To evaluate the effect of iRoot BP Plus as pulp-capping agents on the biological behaviors of stem cells from human exfoliated deciduous teeth (SHED) and human dental pulp stem cells (DPSC). Methods: iRoot BP Plus and ProRoot MTA sample disks were prepared and the extractive solution was extracted from iRoot BP Plus and ProRoot MTA sample disks. The influence of iRoot BP Plus and MTA extracts on the SHED and DPSC proliferation capacity was detected by CCK-8 method at 1, 3, 5 and 7 days.The influence of iRoot BP Plus and MTA extract on the SHED and DPSC migration capacity was observed by Transwell chamber and scratch repair experiments. SHED and DPSC were respectively inoculated on the sample disks of iRoot BP Plus and MTA for culture. Phalloidin and DAPI (4',6-diamidino-2-phenylindole) were used for immunofluorescence staining on 1, 3 and 5 days respectively to observe cytoskeleton changes. SHED and DPSC underwent mineralization induction respectively in osteoblastic induction medium, the osteoblastic induction medium containing MTA extract and the osteoblastic induction medium containing iRoot BP Plus extract. Alkaline phosphatase (ALP) staining and quantitative analysis of ALP were performed at 7 and 14 days, Alizarin Red staining and semi-quantitative analysis of calcium salt deposition were performed at 21 days. SPSS 19.0 software package was used for statistical analysis of the data. Results: iRoot BP Plus and MTA extracts could promote cell proliferation of SHED and DPSC. In cell migration and adhesion experiments, iRoot BP Plus and MTA both promoted migration and adhesion of SHED and DPSC, and iRoot BP Plus played a more significant role (P=0.000). After mineralization induction, the ALP activity of SHED and DPSC in iRoot BP Plus group was significantly greater than that of MTA. Alizarin red staining and semi-quantitative analysis of calcium salt deposition showed that both iRoot BP Plus and MTA could promote cell mineralization. Moreover, the ability of iRoot BP Plus to promote cell mineralization was significantly stronger than that of MTA (P=0.000). Conclusions: iRoot BP Plus and MTA has good biocompatibility and good osteogenetic differentiation ability, it can promote SHED and DPSC cell proliferation, adhesion, migration, and BP Plus has better affect of promoting iRoot SHED and DPSC adhesion, migration and distribution of differentiation than MTA, therefore iRoot BP Plus and MTA may be used as pulp capping agent both for deciduous and permanent teeth. Reference | Related Articles | Metrics

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Classification for retrognathism malocclusions and its predictive assessment of progressive growth patterns SHEN Gang Shanghai Journal of Stomatology    2019, 28 (5): 449-454.   DOI: 10.19439/j.sjos.2019.05.001 Abstract （467）      PDF （4496KB）（669）       Knowledge map    Classification for retrognathism malocclusions, assessed and determined by facial concavity, dento-basal compensation, skeletal discrepancy and mandibular morphology, includes dento-alveolar, mandibular positioning and skeletal categories. The skeletal category further consists of 3 subtypes, namely, maxillary originated, mandibular originated and maxillo-mandibular originated. The inspection of cephalometric images reveals that the mandibular contours in dento-alveolar, mandibular positioning and skeleto-maxillary originated categories present with flat and rectangular shapes; and in skeleto-mandibular originated and maxillo-mandibular originated subtypes, massive triangular shapes are distinctive. A longitudinal observation indicates that, spanning the course from the onset to the cessation of pubertal growth spurt, the prognosis of growth patterns remains stable and relatively favorable in dento-alveolar, mandibular positioning and skeleto-maxillary originated categories, but deteriorates and becomes unfavorable in skeleto-mandibular originated and maxillo-mandibular originated subtypes. The skeletal categories with triangle mandible coupled with deep curvature of symphysis hold high likelihood of relapse and are expected to achieve optimal correction by surgical interventions,although the orthopedic therapies are still advisable in the early stage. Reference | Related Articles | Metrics

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Shanghai Journal of Stomatology    2008, 17 (4): 425-429.   Abstract （101）      PDF （899KB）（484）       Knowledge map    Related Articles | Metrics

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Shanghai Journal of Stomatology    2009, 18 (5): 475-479.   Abstract （81）      PDF （779KB）（438）       Knowledge map    Related Articles | Metrics

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Inhibition of connexin 43-mediated hemichannel activity promotes odontoblast differentiation of human dental pulp cells induced by lipopolysaccharide ZHANG An-ni, DING Can-can, HUANG Li-ping, LI Shi-ting Shanghai Journal of Stomatology    2024, 33 (1): 22-29.   DOI: 10.19439/j.sjos.2024.01.004 Abstract （70）      PDF （2155KB）（95）       Knowledge map    PURPOSE: To investigate the role and mechanism of connexin 43（Cx43）in odontoblast differentiation of human dental pulp cells (hDPCs) induced by lipopolysaccharide (LPS). METHODS: The maxillary first molar injury model of SD rats was established. The expression pattern of Cx43 in dental pulp repair after injury was detected by immunofluorescence(IF) staining. hDPCs was respectively stimulated with 0, 1, 10, 100 and 1 000 ng/mL LPS for 6 h to screen the optimal concentration, and then the expression of Cx43 was inhibited and overexpressed in hDPCs. Quantitative real-time PCR(qRT-PCR) and Western blot(WB) were used to detect the expression of Cx43 and dentin sialophosphoprotein (DSPP), dental matrix protein-1 (DMP-1), osterix (Osx) and extracellular signal-regulated kinase (ERK) activity. Furthermore, hDPCs were treated with specific Cx43 channel inhibitors to investigate the effect of Cx43-mediated channel activity in odontoblast differentiation of hDPCs, and to explore the role and mechanism of Cx43 in regulating odontoblast differentiation of hDPCs induced by LPS. Statistical analysis was performed with SPSS 26.0 software package. RESULTS: IF results showed that Cx43 was mainly expressed in the odontoblast layer in healthy dental pulp tissues. At 3-24 h after tooth injury, the expression of Cx43 decreased and then gradually increased to the normal level; from 3 days to 2 weeks after injury, the expression of Cx43 tended to be down-regulated which was in the odontoblast layer and pulp proper. The expression of DSPP mRNA was significantly up-regulated in the hDPCs stimulated with 10 ng/mL LPS for 6 h(P<0.01). Inhibition of Cx43 significantly up-regulated the expression of DSPP, DMP-1 and Osx mRNA induced by LPS in hDPCs(P<0.05), while overexpression of Cx43 obviously inhibited the expression of factors related to LPS-induced odontoblast differentiation(P<0.01) and the fluorescence intensity of DSPP. 10 ng/mL LPS activated ERK signal in hDPCs, and overexpression of Cx43 significantly attenuated the activity of ERK signal induced by LPS(P<0.01). Inhibition of Cx43-mediated hemichannel (HC) promoted mRNA expression of factors related to odontoblast differentiation in hDPCs and the activity of ERK signal induced by LPS(P<0.05), while blocking Cx43-mediated gap junction channel (GJC) inhibited odontoblast differentiation. CONCLUSIONS: Cx43 participates in the regulation of dental pulp repair after injury, and its expression shows a downward trend as a whole. Inhibition of Cx43 or blocking of HC promotes LPS-induced ERK signal activity and odontoblast differentiation of hDPCs. Reference | Related Articles | Metrics

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Shanghai Journal of Stomatology    2007, 16 (3): 236-238.   Abstract （450）      PDF （606KB）（775）       Knowledge map    Related Articles | Metrics

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Changes of TGF-β1 expression during orthodontic tooth movement in rats with osteoporosis LI Ming-he, WANG Yang, LIAO Nan-nan, LI Jin-yuan, DONG Qing Shanghai Journal of Stomatology    2017, 26 (1): 17-20.   DOI: 10.19439/j.sjos.2017.01.004 Abstract （231）      PDF （1181KB）（275）       Knowledge map    ] PURPOSES: To observe the expression and distribution of TGF-β1 in periodontal tissue under intervention of Strontium ranelate and Qianggu capsule during orthodontic tooth movement in rats, and explore the efficacy of the 2 drugs. METHODS: Seventy male SD rats of 3 months old were selected in the study, and randomly divided into control group, model control group, Strontium ranelate group, Qianggu capsule group, each group had 15 animals. Retinoic acid was given by gavage to animals in the control group, Strontium ranelate group, Qianggu capsule group for 2 weeks, and bone density was detected to determine successful establishment of osteoporosis model. All rats were installed orthodontic device, and were sacrificed at 7 days, 14 days and 21 days, respectively. The tissue blocks of the first maxillary molar and adjacent alveolar bone were taken for H-E staining, immunohistochemical staining and semi-quantitative analysis was used to detect TGF-β1 expression in periodontal tissues. The data were statistically analyzed by SPSS 17.0 software package. RESULTS: TGF- beta 1 expression was significantly increased in Strontium ranelate group and Qianggu capsule group compared with control group (P<0.05); TGF- beta 1 expression in Strontium ranelate group was significantly stronger than that of Qianggu capsule group (P<0.05). CONCLUSIONS: Strontium ranelate and Qianggu capsule could enhance the expression of TGF- beta 1 and promote bone metabolism in osteoporosis rats, which is helpful to the movement of healthy teeth; the effect of Strontium ranelate is stronger than Qianggu capsule. Reference | Related Articles | Metrics

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Bone morphogenetic protein-2, -4, -6, -7 and -9 differentially mediated osteogenic differentiation of immortalized odontoblasts LI Jing, ZHANG Yi, WANG Jin-hua Shanghai Journal of Stomatology    2020, 29 (3): 242-249.   DOI: 10.19439/j.sjos.2020.03.004 Abstract （255）      PDF （1611KB）（437）       Knowledge map    PURPOSE: This study was aimed to investigate the mesenchymal stem cell (MSC) phenotypes of immortalized odontoblasts(iODs) and bone morphogenetic protein -2, -4, -6, -7, and -9 (BMPs) differentially regulate the mineralization of iODs. METHODS: ODs were immortalized by SV40 T antigen to establish iOD lineages, and the endogenous expression of BMPs was successively examined. Recombinant adenoviruses expressing BMPs and GFP were generated using Ad-Easy technology. The proliferation capability of iODs was examined using an MTT kit. MSC markers of iODs were examined by immunofluorescence. In vitro, semiquantitative RT-PCR, alkaline phosphatase(ALP) activity assay, matrix mineralization assay and oil red O staining assay were used to examine the osteogenic and adipogenic differentiation capabilities of iODs. Statistical significance among groups was analyzed by one-way analysis of variance and Scheffe's multiple comparison test was SPSS 21.0 software package. Finally, the volume and density of ectopic mineralized tissues formed in vivo were assessed by micro-CT and histological analysis. RESULTS: ODs can be efficiently immortalized by SV40 T antigen, and the resulting iODs maintained an excellent proliferative activity, expressed certain MSC markers and possessed multiple differentiation capabilities. BMP-2 and BMP-9 regulated iODs osteogenic differentiation better than BMP-4, -6, and -7. CONCLUSIONS: Our findings suggest that ODs and osteogenic growth factors such as BMP-2 and BMP-9 can be used as an efficacious strategy for bone tissue engineering. Reference | Related Articles | Metrics

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Biological characteristics and osteogenic differentiation of magnesium-doped nanoporous titanium coating ZHAO Shan, ZHANG Lin, LI Sheng-nan, KANG Nan, MENG Jian, LI Xiao-dong Shanghai Journal of Stomatology    2024, 33 (1): 6-12.   DOI: 10.19439/j.sjos.2024.01.002 Abstract （82）      PDF （2088KB）（94）       Knowledge map    PURPOSE: Bioactive magnesium ions were successfully incorporated into the nanoporous titanium base coating by micro-arc oxidation(MAO), and its physical properties and osteogenic effects were explored. METHODS: Non-magnesium-containing and magnesium-containing titanium porous titanium coatings(MAO, MAO-mg) were prepared by changing the composition of MAO electrolyte and controlling the doping of magnesium in porous titanium coatings. The samples were characterized by scanning electron microscope (SEM), roughness, contact angle and energy dispersive X-ray spectrometer (EDS). Mg2+ release ability of magnesium-doped nanoporous titanium coatings was determined by inductively coupled plasma/optical emission spectrometer(ICP-OES). The structure of the cytoskeleton was determined by live/dead double staining, CCK-8 detection of material proliferation-toxicity, and staining of β-actin using FITC-phalloidin. The effects of the coating on osteogenic differentiation in vitro were determined by alizarin red (ARS), alkaline phosphatase (ALP) staining and real-time polymerase chain reaction (qRT-PCR). SPSS 25.0 software package was used for statistical analysis. RESULTS: The MAO electrolyte with magnesium ions did not change the surface characteristics of the porous titanium coating. Each group prepared by MAO had similar microporous structure(P>0.05). There was no significant difference in surface roughness and contact angle between MAO treatment group (MAO, MAO-mg)(P>0.05), but significantly higher than that of Ti group (P<0.05). With the passage of cell culture time, MAO-mg group promoted cell proliferation (P<0.05). MAO-mg group was significantly higher than other groups in ALP and ARS staining. The expression of Runx2 mRNA (P<0.05), ALP(P<0.05) and osteocalcin OCN(P<0.05) in MAO-mg group was significantly higher than that in Ti and MAO groups. CONCLUSIONS: MAO successfully prepared magnesium-containing nanoporous titanium coating, and showed a significant role in promoting osteogenic differentiation. Reference | Related Articles | Metrics

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Shanghai Journal of Stomatology    2008, 17 (6): 591-594.   Abstract （248）      PDF （765KB）（611）       Knowledge map    Related Articles | Metrics

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Shanghai Journal of Stomatology    2009, 18 (4): 415-418.   Abstract （66）      PDF （807KB）（573）       Knowledge map    Related Articles | Metrics