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    Mechanism of chloroquine in promoting sensitivity of chemotherapeutics in oral squamous cell carcinoma CAL-27 cell line to cisplatin
    QUAN Hai-ying,ZHOU Li-jia,LI Ang-di,Zhang Ze-bing
    Shanghai Journal of Stomatology    2015, 24 (1): 30-36.  
    Abstract306)   HTML1)    PDF (1121KB)(360)      
    PURPOSE: To study the role and mechanism of autophagy in chemotherapy of oral squamous cell carcinoma, and provide theoretical evidence to improve chemotherapeutic efficacy of oral squamous cell carcinoma patients. METHODS: The cell survival rate changes induced by cisplatin (DDP) and chloroquine (CQ) in CAL-27 cells were assayed by methyl thiazolyl tetrazolium method(MTT). The LC3-Ⅱ expression level was detected by laser scanning confocal microscope; The apoptotic rate was determined by flow cytometry. SPSS17.0 software package was used for statistical analysis. RESULTS: MTT results showed that compared with the control group, the cell survival rate reduced with the increasing time of DDP and CQ treatment; The optimal concentration of CAL-27 cells was 5 mg/L after treatment with CQ. IC50 of the CAL-27 cells was 5 mg/L after treatment with DDP; MTT results showed that the cell survival rate of CQ+DDP group was significantly lower than control group, CQ group and DDP group (P<0.05). With the action of CQ and DDP to CAL-27 cells for 48 hours, immunofluorescence results showed that the average fluorescence intensity of DDP group was significantly higher than the other 3 groups (P<0.05), while it was significantly lower in CQ group than the other 3 groups (P<0.05). With the action of CQ and DDP to CAL-27 cells for 48 hours, flow cytometry results showed that the cell apoptosis rate of DDP group and CQ+DDP group were significantly higher than control group and CQ group. The cell apoptosis rate of CQ+DDP group was significantly higher than DDP group (P<0.05). With the action of CQ and DDP to CAL-27 cells for 48 hours, cells in G1 phase of DDP group and CQ+DDP group increased, indicating G1 phase blockage. The cell count in G1 phase of CQ+DDP group was significantly higher than DDP group (P<0.05). CONCLUSIONS: Inhibition of autophagy can enhance the chemotherapeutic sensitivity of DDP in CAL-27 cells. Autophagy in CAL-27 cells is an important mechanism for chemotherapy resistance of oral squamous cell carcinoma. Autophagy inhibitor may have significant potential to be a novel chemotherapeutic sensitizer for oral squamous cell carcinoma.
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    Cited: Baidu(10)
    Expression of Ki-67 and P53 protein in oral squamous cell carcinoma and its clinical significance
    HE Wei,XIAO Yan,CHEN Wei-min
    Shanghai Journal of Stomatology    2015, 24 (2): 228-231.  
    Abstract372)   HTML0)    PDF (1060KB)(264)      
    PURPOSE: To investigate the clinical and pathological features and its relationship with the expression of Ki-67 and p53 protein in oral squamous cell carcinoma. METHODS: Immunohistochemical SP staining method was used to quantify the protein expression levels of Ki-67 and p53 protein in 10 cases of normal oral mucosa, 16 cases of oral leukoplakia (OLK) tissue, and 48 cases of oral squamous cell carcinoma. The relationship of the expression of Ki-67 and p53 protein to clinical and pathological data was analyzed, and SPSS17.0 software package was used for statistical analysis. RESULTS: The positive expression rate of Ki-67 protein in normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma was 30%, 56.3% and 79.2%, respectively; The positive expression rate of p53 was 0%, 43.8%, and 70.8%, respectively; Ki-67 and p53 expression had significant difference among normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma (P<0.05); The expression of Ki-67 protein was significantly elevated with tumor stage, differentiation and cervical lymph node metastasis (P<0.05); The expression of p53 protein was significantly related to the degree of tumor differentiation (P<0.05); The expression of Ki-67 and p53 was positively correlated in oral squamous cell carcinoma (P<0.05). CONCLUSIONS: The high expression of Ki-67 and p53 protein in oral squamous cell carcinoma tissues may play an important role in the development of oral squamous cell carcinoma.
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    Cited: Baidu(10)
    Comparison of root resorption between self-ligating and conventional brackets using cone-beam CT
    LIU Yun,GUO Hong-ming
    Shanghai Journal of Stomatology    2016, 25 (2): 238-241.  
    Abstract350)   HTML4)    PDF (872KB)(1025)      
    PURPOSE: To analyze the differences of root resorption between passive self-ligating and conventional brackets, and to determine the relationship between passive self-ligating brackets and root resorption. METHODS: Fifty patients were randomly divided into 2 groups using passive self-ligating brackets or conventional straight wire brackets (0.022 system), respectively. Cone-beam CT was taken before and after treatment. The amount of external apical root resorption of maxillary incisors was measured on CBCT images. Student's t test was performed to analyze the differences of root apical resorption between the 2 groups with SPSS17.0 software package. RESULTS: No significant difference(P> 0.05) in root resorption of maxillary incisors was found between passive self-ligating brackets and conventional brackets. CONCLUSIONS: Passive self-ligating brackets and conventional brackets can cause root resorption, but the difference was not significant. Passive self-ligating brackets do not induce more root resorption.
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    Cited: Baidu(9)
    Survey of the coverage and influencing factors of pit and fissure sealants in primary and middle school of Hangzhou city
    FANG Da-feng, CHEN Yan-juan, CHEN Yao, CHEN Hui
    Shanghai Journal of Stomatology    2014, 23 (1): 95-98.  
    Abstract148)   HTML1)    PDF (508KB)(259)      
    PURPOSE: To investigate the coverage of pit and fissure sealants in primary and middle school students of Hangzhou city, and to explore the causes of unsealing students. METHODS: An analysis of sealing rate and unsealing causes of eligible children in Hangzhou city was carried out, using 3-year data of pit and fissure sealants program sponsored by the government. Based on the results, the validity of pit and fissure sealants as a government-sponsored public health program was evaluated. RESULTS: The sealing rate was 52.89%. The main reasons of unsealing were uneruption and incomplete eruption of teeth when the medical teams went to school for pit and fissure sealing. CONCLUSIONS: The main reason of unsealing is eruption issue, which can be controllable. Some scientific adjustments need to be made to improve the coverage, such as increasing sealing times considering the difference of teeth eruption.
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    Cited: Baidu(9)
    Comparison of the clinical effects of selective laser melting deposition basal crowns and cobalt chromium alloy base crowns
    LI Jing-min, WANG Wei-qian, MA Jing-yuan
    Shanghai Journal of Stomatology    2014, 23 (3): 350-353.  
    Abstract178)   HTML0)    PDF (531KB)(262)      
    PURPOSE: To evaluate the clinical effects of selective laser melting (SLM) deposition basal crowns and cobalt chromium alloy casting base crowns. METHODS: One hundred and sixty eight patients treated with either SLM deposition basal crowns (110 teeth) or cobalt chromium alloy casting basal crowns (110 teeth) were followed-up for 1 month, 6months, 12months and 24 months. The revised standard of American Public Health Association was used to evaluate the clinical effect of restoration, including the color of porcelain crowns, gingival inflammation, gingival margin discoloration, and crack or fracture. Data analysis was conducted with SPSS 20 software package for Student’s t test and Chi-square test. RESULTS: Six cases were lost to follow-up. The patients who were treated with SLM deposition basal crowns (104 teeth) and cobalt chromium alloy casting base crowns (101 teeth) completed the study. Patients were more satisfied with SLM deposition cobalt chromium alloy porcelain crowns. There was 1 prosthesis with poor marginal fit after 24 months of restoration in SLM crowns. There were 6 prostheses with edge coloring and 8 with poor marginal fit in cobalt chromium alloy casting base crowns, which was significantly different between the 2 groups(P<0.05). CONCLUSIONS: The SLM deposition copings results in smaller edge coloring and better marginal fit than those of cobalt-chrome copings. Patients are pleased with short-term clinical results.
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    Cited: Baidu(8)
    Preliminary study on root canal morphology of maxillary second molars
    LI Li, ZHAN Fu-liang, JIN Ying-wu
    Shanghai Journal of Stomatology    2014, 23 (2): 179-183.  
    Abstract1613)   HTML1)    PDF (982KB)(335)      
    PURPOSE: To investigate the root canal morphology and anatomy of maxillary second molars using transparent tooth technique and cone-beam computed tomography (CBCT), and explore the consistency of 2 methods in identifying root canal configurations and morphology. METHODS: Fifty extracted maxillary second molars were scanned by CBCT and analyzed using assistant software. Root canal configurations of each root were identified based on Vertucci's classification and recorded. All transparent teeth samples were made with modified root canal staining technique, and the root canal configurations of each root were classified based on Vertucci's classification. The results were analyzed statistically with SPSS17.0 software package. RESULTS: According to transparent tooth technique, typeⅠ was the most common configuration in distobuccal root and palatal root. An additional configuration type 3-2-2 was found in the present study, which was not included in Vertucci’s classification. The wide variety of canal systems was seen in the mesiobuccal root. TypeⅠconfiguration was most prevalent(54.4%), followed by TypeⅡ, Ⅳ, Ⅴ, Ⅵ. The prevalence of second canal in mesiobuccal root (MB2) was 41.3%. The results of canal morphology and configuration were consistent between transparent tooth technique and CBCT. CONCLUSIONS: Maxillary second molars have the most complex root and canal morphology, especially for the mesiobuccal root. For identifying root canal and root anatomy, CBCT can be used as an alternative to transparent tooth technique in clinical practice. The application of 3D reconstruction based on CBCT helps us to visualize the root canal anatomy.
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    Cited: Baidu(8)
    p38 signal pathway regulates osteogenic differentiation of maxillary primordium mesenchymal cells
    ZHAO Yi-song,ZHONG Hui-min,HE Zhi-wei,ZHANG Guo-liang,WU Jiang
    Shanghai Journal of Stomatology    2015, 24 (1): 56-60.  
    Abstract189)   HTML0)    PDF (938KB)(193)      
    PURPOSE: To explore whether p38 signal pathway regulates osteogenic differentiation of maxillary primordium mesenchymal cells. METHODS: The first passage of maxillary primordium mesenchymal cells (MPMCs) from E12.5 embryos were cultured in the osteogenic medium, and 10 nM SB203580 (an inhibitor of phosphorylation of p38) was added in the medium in the experimental group for 1 week. Then immunofluorescence staining was applied to detect the phosphorylation of p38 in MPMCs. Brdu label and immunofluorescence staining were used to detect the proliferation of MPMCs. ALP staining and qPCR were used to detect the mRNA expression of ALP, Runx2, OCN and OPN in MPMCs. ALP staining and PCR were used to evaluate the osteogenic capability of MPMCs. SPSS 18.0 software package was used to analyze the data. RESULTS: Osteogenic induction could promote phosphorylation of p38, inhibit phosphorylation of p38 and proliferation of MPMCs, down-regulate the expression of ALP, Runx2, OCN and OPN, thus weaken the ALP staining in MPMCs. CONCLUSIONS: p38 signal pathway regulates osteogenic differentiation of MPMCs in vitro.
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    Cited: Baidu(6)
    Evaluation of the results of high-speed handpiece and minimally invasive extraction in impacted mandibular third molar extraction
    YANG Ying-yang, DU Sheng-nan, LV Zong-kai
    Shanghai Journal of Stomatology    2015, 24 (4): 489-492.  
    Abstract462)   HTML1)    PDF (653KB)(244)      
    PURPOSE: To compare the results of high-speed handpiece and minimally invasive extraction in impacted mandibular third molar extraction. METHODS: From May 2011 to May 2014, 83 patients undergoing impacted mandibular third molar extraction were enrolled into the study and randomly divided into 2 groups: 42 patients in group A (experimental group) and 41 patients in group B (control group). Group B underwent extraction with traditional method and group A underwent high-speed handpiece and minimally invasive extraction of the impacted mandibular third molar. The occurrences of the root fracture, gingival laceration, tooth mobility, lingual bone plate fracture, jaw fracture and dislocation of temporomandibular joint during operation and lower lip numbness, dry socket, facial swelling and limitation of mouth opening after operation were observed and compared between 2 groups. The operation time, integrity of extraction sockets, VAS pain score and satisfaction from patients were collected and compared. SPSS 19.0 software package was used for statistical analysis. RESULTS: The occurrences of root fracture, gingival laceration, tooth mobility, lingual bone plate fracture, jaw fracture, and dislocation of temporomandibular joint during operation in group A significantly decreased compared with group B (P<0.05). The occurrences of lower lip numbness, dry socket, facial swelling and limitation of mouth opening after operation in group A significantly decreased compared with group B (P<0.05). The operation time, integrity of extraction sockets, VAS pain scores and satisfaction scores in group A improved significantly compared with group B (P<0.05). CONCLUSIONS: High-speed handpiece and minimally invasive extraction should be widely used in impacted mandibular third molar extraction, due to the advantages of simple operation, high efficiency, minimal trauma, and few perioperative complications.
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    Cited: Baidu(6)
    The effect of dental health instruction before treatment on anxiety of patients with acute pulpitis
    TANG Yu, DU Rong
    Shanghai Journal of Stomatology    2015, 24 (4): 483-485.  
    Abstract292)   HTML2)    PDF (391KB)(233)      
    PURPOSE: To evaluate the effect of dental health instruction before treatment on dental anxiety of patients with acute pulpitis. METHODS: One hundred and fifty-four patients with acute pulpitis treated in our department from July 2011 to June 2013, and aged from 19 years to 64 years, were selected. They were randomly divided into experimental group and control group. Seventy-eight patients of the experimental group accepted dental health instruction before treatment, while 76 cases in the control group received regular treatment. Two questionaires of dental anxiety were proceeded to both groups respectively before treatment. The data was analyzed for Student’s t test and Chi-square test using SPSS12.0 software package. RESULTS: Dental anxiety (DA) points of the experimental group after dental health instruction were significantly lower than that before treatment (t=4.1346, P<0.01). DA points of the experimental group after dental health instruction were significantly lower than that of the control group (t=6.2784, P< 0.01). The acceptability of the experimental group towards the first treatment was significantly higher than of the control group. The completion rate of the following treatment of the experimental group was also significantly higher than that of the control group. CONCLUSIONS: Dental health instruction to patients with acute pulpitis before treatment are helpful to reduce the pressure and relieve the anxiety during the treatment, so that the patients will complete the first and the following treatment successfully.
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    Cited: Baidu(5)
    The reliability of the salivary occult blood to test gingival inflammation
    HUANG Jia-ni, YIN Yuan-zheng, Ding Jin
    Shanghai Journal of Stomatology    2014, 23 (1): 87-90.  
    Abstract288)   HTML0)    PDF (649KB)(203)      
    PURPOSE: To evaluate the reliability of salivary occult blood test(SOBT) for gingival inflammation. METHODS: Forty-five pre- and post-stimulation saliva samples were tested for occult blood, with bleeding on probing (BOP) as an indicator of gingival inflammation. Subjects with BOP%<15% were defined as control group. The examinations were repeated 3 months after periodontal initial therapy. The relationship between the results of SOBT and gingival inflammation was analyzed. SAS6.12 software package was used for statistical analysis. RESULTS: The SOBT of pre-stimulation was higher in gingivitis group than in control group (P<0.05). BOP% and SOBT of post-therapy was significantly decreased (P<0.01), with 90% of pre- and 63% of post-stimulation SOBT turning negative. The sensitivity and specificity of pre- stimulation SOBT in screening gingivitis were 32.35% and 100%. The sensitivity and specificity of the post-stimulation SOBT were 88.24% and 81.82%. CONCLUSIONS: SOBT is correlated with gingival inflammation, which may be used as an objective parameter to evaluate gingival inflammation and the efficacy of periodontal therapy at individual level. It may offer a simple screening method for gingival inflammation applied in periodontal epidemiologic studies in large population.
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    Cited: Baidu(5)
    Detection and the immune status of regulatory T cells in experimental periodontitis
    JIN Ying, WANG Lin-yuan, LIN Xiao-ping
    Shanghai Journal of Stomatology    2013, 22 (5): 487-491.  
    Abstract244)      PDF (1101KB)(287)      
    PURPOSE: To establish animal model in mice with orally infected periodontitis with Porphyromonas gingivalis and intraperitoneal injection of P.g antigen, simulate periodontal pathogens of human periodontal disease, and analyze the expression of regulatory T cells in this model. METHODS: The extent of periodontal bone resorption was measured by entity microscope, and inflammatory cell infiltration of the periodontal tissue lesions was observed by HE staining. Flow cytometric analysis was used to detect the expression of regulatory T cells in periodontal disease during the chronic inflammation. The expression levels of TGF-β1, IL-10mRNA in periodontal tissue were detected by real-time quantitative PCR. SPSS 17.0 software package was used for statistical analysis. RESULTS: After 4 weeks, compared with the normal control group, the distance between cemento-enamel junction and the alveolar crest was significantly increased in periodontal disease group(P<0.05); Massive inflammatory cells were infiltrated and periodontal pockets deepened in periodontal tissue. The expression levels of TGF-β1 and IL-10mRNA were significantly decreased (P<0.01). The ratio and numbers of Treg cells were significantly reduced in the spleen (P<0.05). CONCLUSIONS: In experimental periodontitis, the number and the function of regulatory T cells are abnormal. It may be relevant to the reduction of immune suppression cytokines.
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    Cited: Baidu(5)
    Clinical analysis of caries status of the mandibular second molar
    YOU Chun-an, ZHENG Ping, HU Ning, SU Qin
    Shanghai Journal of Stomatology    2014, 23 (2): 233-236.  
    Abstract298)   HTML0)    PDF (474KB)(229)      
    PURPOSE: To collect the cases which have caries on the mandibular second molar and analyze the caries status and correlative factors. METHODS: Patients treated in the Department of Endodontics in West China Hospital of Stomatology were randomly collected. The baseline information, primary sites and severity of dental caries on the mandibular second molar, and eruption pattern of the mandibular third molar were recorded. The data was analyzed with SPSS13.0 software package. RESULTS: Four hundred eighty-one patients including 227 males and 254 females were collected. Caries on the mandibular second molar starting from the occlusal, distal proximal and buccal surfaces accounted for 33.8%, 33.2% and 24.4%, respectively. Caries involving dental pulp (49.7%) were significantly more than deep and shallow to moderate caries (31.7% and 18.6%). Gender was not correlated with the site and severity of caries. However, impacted mandibular third molars and age were significantly related to both caries site and severity. CONCLUSIONS: Occlusal and distal proximal surfaces are the most predisposed sites to have caries on mandibular second molar. Impacted mandibular third molar and age are significantly related to caries of mandibular second molar.
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    Cited: Baidu(5)
    Clinical evaluation on the preparation of cured root canals with Reciproc and Pathfile rotary instruments
    CHEN Feng, QIAO Jia-yun, LI Xiao-feng
    Shanghai Journal of Stomatology    2013, 22 (3): 338-341.  
    Abstract200)      PDF (512KB)(355)      
    PURPOSE: To evaluate the effect of cured molar root canal preparation using Reciproc and Pathfile rotary instruments. METHODS: From December 2012 to January 2013, 88 teeth with 273 root canals were randomly divided into three groups. In group A, root canals were prepared with Reciproc and Pathfile. In group B, root canals were prepared with ProTaper and Pathfile. In group C, root canals were prepared with rotary ProTaper. All root canals were filled with continuous wave condensation. The operating time for each root canal, the incidence of instrument separation and postoperative pain were recorded. The efficiency of reparation was analyzed with radiograph. The data was analyzed with SPSS17.0 software package. RESULTS: In group A, the mean operation time was significantly shorter without instrument separation, transportation and ledge. The technique could keep the curvature and flow of curved canals. Postoperative pain was significantly lower, and appropriate filling of root canals was significantly higher than in other groups (P<0.01). CONCLUSIONS: Curved root canal preparation with Reciproc and Pathfile is less time consuming and more convenient with fewer side effects. It is an efficient instrumentation for curved canals and can be used widely.
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    Cited: Baidu(5)
    The establishment of digital model about sagittal split ramus osteotomy and stability analysis of 3 different fixation methods
    YIN Xue-min, ZHANG Jun-wei, REN Xiao-xu, XU Guo-xiang, LIU Xiao
    Shanghai Journal of Stomatology    2013, 22 (3): 241-246.  
    Abstract252)      PDF (1171KB)(247)      
    PURPOSE: To establish the digital model about sagittal split ramus osteotomy and discuss the stress and displacement of 3 different fixation methods. METHODS: Three-dimensional reconstruction software Mimics and Geomagic were used to establish the three-dimensional entity model of mandible, and simulated sagittal split ramus osteotomy and fixation. Three-dimensional finite element model was established by mesh generation through ANSYS. After boundary constraint the occlusal load of 132N on the bilateral lower first molars was applied. RESULTS: Three-dimensional finite element models of sagittal split ramus osteotomy and 3 different fixation methods were established, and the biomechanical character of stress and displacement after occlusal load preoperatively and after splitting mandibles were found. CONCLUSIONS: As the stress distribution tends to uniformity and the displacement at split area is the least one, the fixation by bicortical screws in inverted-L position after sagittal split ramus osteotomy is the stablest of the 3 fixation methods.
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    Cited: Baidu(4)
    Effect of two different kinds of occlusal splints on temporomandibular disorders
    CHEN Ting, LIAO Tian-an, ZHAN Ruo-jun, WU Li-na
    Shanghai Journal of Stomatology    2013, 22 (5): 547-550.  
    Abstract209)      PDF (527KB)(244)      
    PURPOSE: To investigate the effect of relaxed splint and stabilized splint on the treatment of temporomandibular disorders (TMD). METHODS: A total of 68 TMD patients were divided into 2 groups (30 patients with acute pain and 38 patients with chronic pain) and treated with relaxed splint or stabilized splint. Visual analog scale (VAS) scores and electromyography (EMG) of bilateral anterior temporal muscle (TA) and masseter muscle (MM) were recorded before treatment and 1 month after treatment. The data was analyzed using variance analysis and student’s t test with SPSS11.0 software package. RESULTS: At rest position, patients’ EMG decreased remarkably (P<0.05) after both kinds of splints treatment. During maximal voluntary clench, the EMG of masticatory muscle (TA, MM) of patients with acute pain and EMG of MM of patients with chronic pain increased significantly after relaxed splint treatment (P<0.05), but only EMG of MM increased significantly after stabilization splint treatment (P<0.05). Patients’ VAS scores decreased remarkably after both kinds of splints treatment (P<0.05), but during function, patients’ acute pain eased remarkably after relaxed splint treatment (P<0.05). CONCLUSIONS: The relaxed splint and stabilized splint can relax the masticatory muscles and ease TMD pain, but relaxed splint has significant effect on the treatment of acute TMD patients.
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    Cited: Baidu(4)
    Study of tape A behavior in patients with oral lichen planus
    SANG Tao, XU Han-mei, YANG Yan-jie, MA Jie
    Shanghai Journal of Stomatology    2014, 23 (1): 91-94.  
    Abstract164)   HTML0)    PDF (493KB)(285)      
    PURPOSE: To study the type of behavior in patients with oral lichen planus (OLP). METHODS: This study included 78 patients who were diagnosed as OLP and 79 healthy people. Using case-control method, subjects in 2 groups completed the questionnaire of type A behavior and SCL-90. Then the results were analyzed with SPSS 19.0 soft ware package. RESULTS: The scores in questionnaire of type A behavior and SCL-90 between the 2 groups had significant difference (P<0.05). CONCLUSIONS: There is a significant correlation between oral lichen planus and type A behavior.
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    Cited: Baidu(4)
    Application of computer-aided surgery in fibrous dysplasia of cranio-maxillofacial bone
    TAN Xin-ying, HU min, TAO Ye, LUO Jin-chao, XU Juan, LIU San-xia
    Shanghai Journal of Stomatology    2014, 23 (1): 62-65.  
    Abstract115)   HTML1)    PDF (1209KB)(204)      
    PURPOSE: To evaluate the effect of computer-aided surgical techniques in surgical treatment of cranio-maxillofacial fibrous dysplasia. METHODS: Twenty-two patients from January 1999 to December 2012 with cranio-maxillofacial fibrous dysplasia were treated in our department. According to the patients’specific conditions, surgeons designed surgical programs, and used computer-assisted surgical techniques to produce skull model and navigation template individually. The effects after surgery were evaluated. RESULTS: Twenty-two patients with resection of the bone lesions restored facial symmetry partially. The patients were followed up for 3 to 36 months, and the treatment effects were satisfactory. CONCLUSIONS: With preoperative planning, intraoperative navigation and postoperative prediction, computer-aided surgery shows its great value in improving the accuracy of cranio-maxillofacial surgery, shortening operating time and restoring facial symmetry. It is regarded as a valuable and safe surgical technique in cranio-maxillofacial surgery.
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    Cited: Baidu(4)
    A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus
    ZUO Wen-xin, LI Xiao-yu, CAI Gan-ying, CHEN Yan-qing
    Shanghai Journal of Stomatology    2013, 22 (6): 708-710.  
    Abstract526)      PDF (424KB)(361)      
    PURPOSE: To evaluate the efficacy and safety of tacrolimus mouth rinse on the treatment of erosive and ulcerative oral lichen planus (OLP). METHODS: A randomized single-blind open trial of tacrolimus mouth rinse with dexamethasone as control was designed. The VAS and REU scoring system was utilized to compare the signs and symptoms. The scores and therapeutic effects were analyzed with SPSS 17.0 software package. RESULTS: There was no significant difference in effective rate between the treatment group and control group(χ2=0.295、0.413, P>0.01)at 4-week and 12-week after treatment. There was significant difference in REU scores between the 2 groups (P<0.01) 4 weeks after treatment. CONCLUSIONS: Tacrolimus mouth rinse effects quickly and is worthy of application in the treatment of erosive and ulcerative OLP.
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    Cited: Baidu(4)
    Treatment of adult bimaxillary arch protrusion with micro-implant anchorage
    CHEN Cheng,ZHANG Xiao-rong
    Shanghai Journal of Stomatology    2015, 24 (1): 76-82.  
    Abstract275)   HTML0)    PDF (987KB)(243)      
    PURPOSE: In this study, micro-implants were used in 15 adult patients with mild and moderate bimaxillary arch protrusion or crowding. Cephalometric analysis was used to analyze hard and soft-tissues change before and after treatment, with the aim to investigate the effects of treatment on adult bimaxillary arch protrusion with micro-implant anchorage. METHODS: Fifteen adult patients with mild and moderate bimaxillary arch protrusion were selected in this study. Micro-implants were inserted into the zygomaticoalveolar ridge of maxilla and the external oblique line of mandible. A NiTi coil spring was attached to the micro-implant to drag the whole upper and lower dentition for distal movement. Cephalometrics were taken before and after treatment, and the changes of soft and hard-tissue profile were studied. SPSS13.0 software package was used to analyze the data. RESULTS: ①Sixty micro-implants remained stable.②SNA, SNB had no significant changes (P>0.05), and the relationship between the maxilla and the mandible did not change significantly. U1/NA, U1-NA, L1/NB, L1-NB and U1/L1 changes in hard tissue had significant difference in cephalometric measurement (P<0.05). The upper and lower anterior teeth were more retrusive, and the tipping of incisor decreased significantly.③Cephalometric analysis showed that lateral appearance improved and soft tissue cephalometric-related measurements such as Cm-Sn-UL,LL-B’-Pos increased significantly (P<0.01). ④Molars and incisors acquired distal movement. CONCLUSIONS: Micro-implant can provide not only excellent skeletal anchorage but also a novel way to distalize the whole dentition efficiently.
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    Cited: Baidu(4)
    Clinical efficacy and effects of CAD/CAM zirconia all-ceramic crown and metal-ceramic crown restoration on periodontal tissues
    XU Xin-yi, ZHANG Yin-lian, GENG Fang-hui
    Shanghai Journal of Stomatology    2017, 26 (3): 331-335.   DOI: 10.19439/j.sjos.2017.03.023
    Abstract579)      PDF (682KB)(328)      
    PURPOSE: To investigate the clinical efficacy and effects of CAD/CAM zirconia all-ceramic crown, cobalt-chromium alloy and silver-palladium alloy porcelain-fused-to-metal crown restorations on periodontal tissues. METHODS: Forty-nine teeth with crowns in 46 patients were randomly assigned into CAD/CAM zirconia all-ceramic crown group, cobalt-chromium alloy porcelain-fused-to-metal crown group and silver-palladium alloy porcelain-fused-to-metal crown group. The amounts of GCF, TNF-α and IL-6 were analyzed before and 12 months after restorations, and the clinical efficacy was evaluated. RESULTS: Comparing the clinical efficacy within 3 groups, indicators such as color match and the status of gums in CAD/CAM zirconia all-ceramic crown group were significantly better than other 2 groups (P<0.05). The amounts of GCF, TNF-α and IL-6 in CAD/CAM zirconia all-ceramic crown group were also significantly better than other 2 groups (P<0.01). CONCLUSIONS: CAD/CAM zirconia all-ceramic crown restoration had better clinical efficacy than cobalt-chromium alloy and silver-palladium alloy porcelain-fused-to-metal crown restorations with no apparently damage to periodontal tissues.
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    Cited: Baidu(4)