A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus

Shanghai Journal of Stomatology ›› 2013, Vol. 22 ›› Issue (6): 708-710.

• Clinical Study • Previous Articles Next Articles

A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus

ZUO Wen-xin, LI Xiao-yu, CAI Gan-ying, CHEN Yan-qing

Department of Stomatology, the Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital. Shenzhen 518020, Guangdong Province, China

Received:2013-05-20 Revised:2013-07-15 Online:2013-04-12 Published:2013-04-12

Abstract

Abstract: PURPOSE: To evaluate the efficacy and safety of tacrolimus mouth rinse on the treatment of erosive and ulcerative oral lichen planus (OLP). METHODS: A randomized single-blind open trial of tacrolimus mouth rinse with dexamethasone as control was designed. The VAS and REU scoring system was utilized to compare the signs and symptoms. The scores and therapeutic effects were analyzed with SPSS 17.0 software package. RESULTS: There was no significant difference in effective rate between the treatment group and control group(χ²=0.295、0.413, P>0.01)at 4-week and 12-week after treatment. There was significant difference in REU scores between the 2 groups (P<0.01) 4 weeks after treatment. CONCLUSIONS: Tacrolimus mouth rinse effects quickly and is worthy of application in the treatment of erosive and ulcerative OLP.

Key words: Tacrolimus, Mouth rinse, Erosive oral lichen planus

CLC Number:

R781.5

ZUO Wen-xin, LI Xiao-yu, CAI Gan-ying, CHEN Yan-qing. A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus[J]. Shanghai Journal of Stomatology, 2013, 22(6): 708-710.

References

[1] Kaliakatsou F, Hodgson TA, Lewsey JD, et al. Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus[J]. J Am Acad Dermatol, 2002, 46(1): 35-41.
[2] Piboonniyom SO, Treister N, Pitiphat W, et al. Scoring system for monitoring oral lichennoid lesions: a preliminary study [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005, 99(6): 696-703.
[3] 中华口腔医学会口腔黏膜病专业委员会. 口腔扁平苔藓(萎缩型、糜烂型)疗效评价标准(试行)[J]. 中华口腔医学杂志, 2005, 40(2): 92-93.
[4] Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies[J]. Clin Dematol, 2010, 28(1): 100-108.
[5] Malhotra AK, Khaitan BK, Sethuraman G, et al. Betamethasone oral mini-pulse therapy compared with topical triamcinolone acetonide (0.1%) paste in oral lichen planus: a randomized comparative study [J]. J Am Acad Dermatol, 2008, 58(4): 596-602.
[6] Jiang HS, Wynn C, Pan F, et al. Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 production [J]. Transplantation, 2002, 73(11): 1808-1817.
[7] López-Jornet P, Camacho-Alonso F, Salazar-Sanchez N. Topical tacrolimus and pimecrolimus in the treatment of oral lichen planus: an update [J]. J Oral Pathol Med, 2010, 39(3): 201-205.
[8] 左雯鑫, 秦念红, 李晓宇, 等. 他克莫司软膏治疗口腔扁平苔藓的短期疗效评价 [J]. 口腔医学研究, 2011, 27(5): 422-424.
[9] Olivier V, Lacour JP, Mousnier A, et al. Treatment of chronic erosive oral lichen planus with low concentration of topical tacrolimus: an open prospective study [J]. Arch Dermatol, 2002, 138(10): 1335-1338.
[10] Byrd JA, Davis MD, Bruce AJ, et al. Response of oral lichen planus to topical tacrolimus in 37 patients [J]. Arch Dermatol, 2004, 140(12): 1508-1512.
[11] Becker JC, Houben R, Vetter CS, et al. The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report [J]. BMC Cancer, 2006, 6:7.
[12] Lozada-Nur FI, Sroussi HY. Tacrolimus powder in orabase 0.1% for the treatment of oral lichen planus and oral lichenoid lesions: an open clinical trial [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006, 102(6): 744-749.
[13] Hodgson TA, Sahni N, Kaliakatson F, et al. Long-term efficacy and safety of topical tacrolimus in the management of ulcerative/erosive oral lichen planus[J]. Eur J Dermatol,2003,13(5):466-470.
[14] Thomson MA, Hamburger J, Stewart DG, et al. Treatment of erosive oral lichen planus with topical tacrolimus[J]. J Dermatolog Treat, 2004, 15(5): 308-314.

A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus

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