Shanghai Journal of Stomatology ›› 2015, Vol. 24 ›› Issue (4): 443-446.

• Basic study • Previous Articles     Next Articles

Grape seed proanthocyanidin extracts inhibit lipopolysaccharide of Porphyromonas gingivalis

CI Xiang-ke, CHEN Li-pei, OU Xiao-yan   

  1. Department of Preventive Dentistry, Affiliated Stomatological Hospital of Nanchang University. Nanchang 330006, Jiangxi Province, China
  • Received:2014-06-18 Online:2015-08-20 Published:2015-09-10
  • Supported by:
    Supported by Research Project of Bureau of Science and Technology of Nanchang City, Jiangxi Province (2014-80)

Abstract: PURPOSE: To study the inhibitory effect of grape seed proanthocyanidin extracts on 1ipopolysacharides of Porphyromonas gingivalis. METHODS: Grape seed proanthocyanidin extracts were to different concentrations by dilution. The effect on Porphyromonas gingivalis was measured by minimal inhibitory concentration (MIC). The inhibition effect of grape seed proanthocyanidin extracts on lipopolysaccharide was measured by limulus assay with 6 concentrations below the minimal inhibitory concentration. SPSS 17.0 software package was used for statistical analysis. RESULTS: The value of MIC of grape seed proanthocyanidin extracts was 0.8 mg/mL to the strains of the experimental bacteria. The inhibitory effect on lipopolysaccharide enhanced with the increasing of the concentration of grape seed proanthocyanidin extracts within the scope of 0.05 to 0.4 mg/mL (P<0.05,0.01). CONCLUSIONS: Grape seed proanthocyanidin extracts have inhibitory effect on lipopolysaccharide of Porphyromonas gingivalis.

Key words: Grape seed proanthocyanidin extracts, Porphyromonas gingivalis, Lipopolysaccharide

CLC Number: