Shanghai Journal of Stomatology ›› 2015, Vol. 24 ›› Issue (1): 89-93.

• Clinical Study • Previous Articles     Next Articles

Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones

KONG Li,WANG Bing-chao,YUAN Rong-tao,JIA Mu-yun,WANG Ke   

  1. Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China
  • Received:2014-04-21 Online:2015-02-20 Published:2015-07-24
  • Supported by:
    Qingdao Municipal Science and Technology Support Program in the Public Domain [11-2-3-1 - (20)-nsh]

Abstract: PURPOSE: To study the role of genes of Wnt signaling pathway in keratocystic odontogenic tumor (KCOT) of the jaw bones. METHODS: Fresh specimens of KCOT and the same patient 's normal oral mucosa were obtained. Then RNA was extracted. Gene chip was used to detect the genes of Wnt signaling pathway. RESULTS: Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated. CONCLUSIONS: There are abnormal expressions of genes of Wnt pathway in KCOT. Genes of Wnt pathway plays certain roles in KCOT.

Key words: Keratocystic odontogenic tumor, Wnt signaling pathway, Oligonudeotide array sequence analysis

CLC Number: