Abstract: PURPOSE: To evaluate the clinical effect of Nd:YAP laser in periodontal regeneration surgery. METHODS: Four weeks after primary periodontal treatment, 48 patients, 60 teeth with bone defect and probing depth(PD) ≥6 mm, bleeding on probing (BOP)(+), were randomly divided into two groups. Patients in the experimental group were treated with Nd:YAP laser combined with periodontal regeneration surgery, while patients in the control group were treated with conventional periodontal regeneration surgery alone. Visual analogue scale(VAS) score was used to evaluate the pain degree of patients 24 hours and 3 days after surgery. The probing depth(PD) and clinical attachment loss(CAL) were examined before and 6 months after surgery, and preoperative and postoperative X-ray images of the two groups were observed and compared. SPSS 26.0 software package was used for statistical analysis. RESULTS: Twenty-four hours and 3 days after surgery, the pain in the experimental group was significantly less than that in the control group (P<0.001), and PD and CAL levels in the two groups were significantly lower 6 months after surgery than before surgery (P<0.001). There was no significant difference in PD and CAL between the two groups before surgery, and the difference was statistically significant 6 months after surgery(P<0.001). X-ray images showed different degrees of new bone formation in alveolar bone defects in the two groups 6 months after surgery. CONCLUSIONS: The application of Nd:YAP laser in periodontal regeneration surgery can reduce postoperative pain and improve the surgical efficacy.

Key words: Nd:YAP laser, Periodontal regeneration surgery, Periodontitis, Bone defect