上海口腔医学

上海口腔医学 ›› 2021, Vol. 30 ›› Issue (5): 543-547.doi: 10.19439/j.sjos.2021.05.019

• 论著 • 上一篇    下一篇

超声热疗联合TPF化疗治疗19例老年晚期口腔鳞癌的疗效分析

李蕾1,2,*, 李晓东2,*, 庄乾伟2, 葛良玉2, 李志萍2, 顾倩平2, 白玉婷2, 孟箭1,2   

  1. 1.潍坊医学院 口腔医学院,山东 潍坊 261053;
    2.徐州市中心医院 口腔科,江苏 徐州 221000
  • 收稿日期:2020-05-28 修回日期:2021-03-04 出版日期:2021-10-25 发布日期:2021-11-08
  • 通讯作者: 孟箭,E-mail:mrocket@126.com
  • 作者简介:李蕾(1992-),女,在读硕士研究生,E-mail:lilywenjian@163.com;李晓东(1992-),男,医师,E-mail:863303398@qq.com。*并列第一作者
  • 基金资助:
    徐州市重点研发计划（20210230）; 江苏省卫生计生委科研课题（H2017080）; 徐州市科技重点研发计划（KC17196）

Analysis of curative effect of ultrasonic hyperthermia combined with TPF chemotherapy on 19 elderly with advanced oral squamous cell carcinoma

LI Lei1,2, LI Xiao-dong2, ZHUANG Qian-wei2, GE Liang-yu2, LI Zhi-ping2, GU Qian-ping2, BAI Yu-ting2, MENG Jian1,2   

  1. 1. School of Stomatology, Weifang Medical University. Weifang 261053, Shandong Province;
    2. Department of Stomatology, Xuzhou Central Hospital. Xuzhou 221000, Jiangsu Province, China
  • Received:2020-05-28 Revised:2021-03-04 Online:2021-10-25 Published:2021-11-08

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摘要： 目的: 观察超声热疗联合TPF化疗对老年晚期口腔鳞状细胞癌（OSCC）的疗效及安全性。方法: 对2017年1月—2020年1月在徐州市中心医院口腔科就诊的19例OSCC老年患者,给予TPF化疗,周期第1天—多西他赛（75 mg/m2）+顺铂（75 mg/m2）,周期第1~5天—5,Fu（750 mg/m2）;在化疗过程中做5次热疗,分别于化疗开始的第l、3、5、7、9天,超声热化疗共2个疗程,观察并评价效果。采用SPSS 20.0软件包进行统计学分析,利用Kaplan-Meire法计算生存率。结果: 根据实体瘤评价标准1.0版,对肿瘤的变化进行疗效评价,其中完全缓解3例,部分缓解10例,疾病稳定5例,疾病进展1例,总有效率为68.4%。中位随访时间为36个月（8~48个月）,2年内生存率为63.2%。不良反应主要表现为常规化疗反应,未见严重不良反应。结论: 超声热疗联合化疗对老年口腔鳞癌患者具有协同抗肿瘤作用,安全有效,有望成为肿瘤治疗的又一种选择。

关键词: 超声热疗, 化疗, 口腔鳞癌, 老年

Abstract: PURPOSE: To evaluate the efficacy and safety of ultrasound hyperthermia combined with TPF chemotherapy for advanced oral squamous cell carcinoma in the elderly. METHODS: Nineteen elderly patients who had definite pathological diagnosis were enrolled in this clinical trail from June 2017 to January 2020. Docetaxel (75 mg/m2) + cisplatin (75 mg/m2) were given on the 1st day, and 5,Fu (750 mg/m2) on the 1st to 5th day of the cycle. Five times of hyperthermia were performed in the course of chemotherapy, respectively on the l, 3, 5, 7 and 9 days after the beginning of chemotherapy. All patients received 2 cycles of thermo -chemotherapy. Statistical analysis was performed using SPSS 20.0 software package. Kaplan-Meire method was used to calculate survival rate. RESULTS: According to the efficacy evaluation standard for solid tumor (version 1.0), complete response (CR) was seen in 3 cases, partial response (PR) was seen in 10 cases, stable disease(SD) was seen in 5 cases,progressive disease(PD) was seen in 1 case. The overall responding rate was 68.4%. The median follow-up time was 36 months(8-48 months), and the 2-year overall survival rates were 63.2%. No serious adverse reactions were observed. CONCLUSIONS: Ultrasound hyperthermic therapy combined with chemotherapy has a synergistic anti-tumor effect on patients with advanced oral squamous cell carcinoma, which is safe and effective, and is worthy of becoming another choice of tumor treatment.

Key words: Ultrasound hyperthermia, Chemotherapy, Oral squamous cell carcinoma, Elderly patients

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