咀嚼槟榔与口腔鳞癌的相关临床病理学因素分析

doi:10.19439/j.sjos.2021.03.009

上海口腔医学 ›› 2021, Vol. 30 ›› Issue (3): 268-272.doi: 10.19439/j.sjos.2021.03.009

咀嚼槟榔与口腔鳞癌的相关临床病理学因素分析

邵小钧¹, 朱乔², 刘有³, 韩小东¹, 林小臻¹, 席庆⁴

1.解放军总医院海南医院口腔科,
2.中心实验室,
3.病理科,海南三亚 572000;
4.解放军总医院口腔科,北京 100835

收稿日期:2019-07-19 修回日期:2020-02-01 出版日期:2021-06-25 发布日期:2021-08-05
通讯作者: 席庆,E-mail: xqsg@sina.com
作者简介:邵小钧（1979-）,男,硕士,主治医师,E-mail: sinsxj@sina.com
基金资助:
三亚市卫生科技创新项目（2015YW34,2017YW23）; 海南省社会发展科技专项（2015SF19）

Correlation of betel nut chewing and clinicopathologic factors of oral squamous cell carcinoma

SHAO Xiao-jun¹, ZHU Qiao², LIU You³, HAN Xiao-dong¹, LIN Xiao-zhen¹, XI Qing⁴

1. Department of Stomatology,
2. Center Lab,
3. Department of Pathology, Hainan Hospital of PLA General Hospital. Sanya 572000, Hainan Province;
4. Department of Stomatology, PLA General Hospital. Beijing 100835, China

Received:2019-07-19 Revised:2020-02-01 Online:2021-06-25 Published:2021-08-05

摘要/Abstract

摘要： 目的: 探讨咀嚼槟榔与口腔鳞癌(oral squamous cell carcinoma,OSCC)相关临床病理学因素及免疫表型的关系。方法: 收集88例OSCC患者资料,根据是否有咀嚼槟榔习惯,分别进行临床病理因素及相关免疫组织化学分析。通过单因素和多因素回归分析,寻找咀嚼槟榔与口腔鳞癌相关的临床病理学因素。采用SPSS 17.0软件包对数据进行统计学分析。结果: 46.6%的OSCC患者有咀嚼槟榔习惯,病变以舌和颊为主,占67.0%,pT分期以T2期为主,占40.9%。在单因素分析中,肿瘤分化程度,ki-67和p53蛋白阳性表达率与咀嚼槟榔习惯显著相关(P<0.05),而性别、年龄、发生部位、pT分期、颈淋巴结转移与咀嚼槟榔习惯无显著相关性(P>0.05);在多因素分析中,肿瘤发生部位和分化程度与咀嚼槟榔习惯有显著相关性(P<0.05)。结论: ki-67和p53蛋白在有咀嚼槟榔习惯组中低表达,预示肿瘤细胞增殖活跃程度、恶性程度、分化程度、预后等临床病理学因素相对良好;有咀嚼槟榔习惯的OSCC患者,肿瘤分化程度相对良好,颊部和舌部是口腔鳞癌的好发部位。

关键词: 槟榔, 口腔鳞癌, 临床病理因素

Abstract: PURPOSE: To investigate the correlation of clinicopathologic factors and immunophenotypic features with betel nut chewing in oral squamous cell carcinoma(OSCC). METHODS: The data of 88 patients with OSCC were collected. According to the habit of betel nut chewing, the clinicopathologic factors and immunohistochemical parameters were analyzed. The relationship between clinicopathologic factors of OSCC and betel nut chewing was analyzed with univariate analysis and multivariate analysis using SPSS 17.0 software package. RESULTS: 46.6% of patients had the habit of betel nut chewing and 67.0% of patients had tongue cancer and buccal cancer. The pathological stages were mainly T2 (40.9%). From univariate analysis of the results, differentiation degree, ki-67, p53 was significantly correlated with the habit of betel nut chewing(P<0.05); while gender, age, location, pathological T stage and cervical lymph node metastasis were not significantly correlated with habit of betel nut chewing (P>0.05). From multivariate analysis of the results, location and differentiation degree were significantly correlated with the habit of betel nut chewing (P<0.05). CONCLUSIONS: ki-67 and p53 protein are lowly expressed in OSCC patients with the habit of betel nut chewing, suggesting that clinicopathologic factors such as the proliferation activity, malignancy, differentiation and prognosis of tumor are much better. Differentiation degree are relatively good in OSCC patients with the habit of betel nut chewing. Cheek and tongue are the most common site of OSCC.

Key words: Betel nut, Oral squamous cell carcinoma, Clinicopathologic factors

中图分类号:

R739.8

邵小钧, 朱乔, 刘有, 韩小东, 林小臻, 席庆. 咀嚼槟榔与口腔鳞癌的相关临床病理学因素分析[J]. 上海口腔医学, 2021, 30(3): 268-272.

SHAO Xiao-jun, ZHU Qiao, LIU You, HAN Xiao-dong, LIN Xiao-zhen, XI Qing. Correlation of betel nut chewing and clinicopathologic factors of oral squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2021, 30(3): 268-272.

参考文献

[1] Müller S.Update from the 4th Edition of the World Health Organization of head and neck tumours: tumours of the oral cavity and mobile tongue[J]. Head Neck Pathol, 2017, 11(1): 33-40.
[2] Thavarajah R, Ranganathan K.Trends in oral squamous cell carcinoma: Diagnosis for effective, evidence-based treatment 2017[J]. J Oral Maxillofac Pathol, 2017, 21(2): 189-191.
[3] Petersen PE.Oral cancer prevention and control-the approach of the World Health Organization[J]. Oral Oncol, 2009, 45(4-5): 454-460.
[4] Javed F, Chotai M, Mehmood A, et al.Oral mucosal disorders associated with habitual gutka usage: a review[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(6): 857-864.
[5] Ray JG, Ganguly M, Rao BS, et al.Clinico-epidemiological profile of oral potentially malignant and malignant conditions among areca nut, tobacco and alcohol users in Eastern India: a hospital based study[J]. J Oral Maxillofac Pathol, 2013, 17(1): 45-50.
[6] 邵小钧, 王金竹, 林小臻, 等. 三亚市居民食用槟榔及相关口腔疾病的流行状况调查[J]. 中国热带医学, 2018, 18(10): 994-998.
[7] Hunt JL.Applications of molecular testing in surgical pathology of the head and neck[J]. Mod Pathol, 2017, 30(s1): S104-S111.
[8] Freudlsperger C, Freier K, Hoffmann J, et al.Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma[J]. Int J Oral Maxillofac Surg, 2012, 41(8): 965-969.
[9] Pei DS, Qian GW, Tian H, et al.Analysis of human Ki-67 gene promoter and identification of the Sp1 binding sites for Ki-67 transcription[J]. Tumour Biol, 2012,33(1): 257-266.
[10] Niikura N, Masuda S, Kumaki N, et al. Prognostic significance of the Ki67 scoring categories in breast cancer subgroups [J]. Clin Breast Cancer, 2014, 14(5): 323-329. e3.
[11] Zargoun IM, Bingle L, Speight PM.DNA ploidy and cell cycle protein expression in oral squamous cell carcinomas with and without lymph node metastases[J]. J Oral Pathol Med, 2017, 46(9): 738-743.
[12] Nathan CO, Amirghahri N, Rice C, et al.Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients[J]. Laryngoscope, 2002, 112(12): 2129-2140.
[13] Shah NG, Trivedi TI, Tankshali RA, et al.Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis[J]. Head Neck, 2009, 31(12): 1544-1556.
[14] Gao L, Gu W, Zheng J, et al.Clinicopathological and prognostic significance of p27 expression in oral squamous cell carcinoma: a meta-analysis[J]. Int J Biol Markers, 2013, 28(4): e329-e335.
[15] Thambiah LJ, Bindushree RV, Anjum A, et al.Evaluating the expression of p16 and p27 in oral epithelial dysplasias and oral squamous cell carcinoma: a diagnostic marker for carcinogenesis[J]. J Oral Maxillofac Pathol, 2018, 22(1): 59-64.
[16] Monteiro LS, Diniz-Freitas M, Warnakulasuriya S, et al.An immunohistochemical score to predict the outcome for oral squamous cell carcinoma[J]. J Oral Pathol Med, 2018, 47(4): 375-381.
[17] Yen AM, Chen SC, Chen TH.Dose-response relationships of oral habits associated with the risk of oral pre-malignant lesions among men who chew betel quid[J]. Oral Oncol, 2007, 43(7): 634-638.

咀嚼槟榔与口腔鳞癌的相关临床病理学因素分析

Correlation of betel nut chewing and clinicopathologic factors of oral squamous cell carcinoma

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