复合纳米羟基磷灰石材料在骨组织修复领域中的研究进展

摘要/Abstract

摘要： 由于人体骨组织中主要无机成分为纳米羟基磷灰石, 人工合成纳米羟基磷灰石成为骨组织修复领域中的研究热点。而为弥补纳米羟基磷灰石材料本身的多方面不足, 复合材料应运而生。本文就常见纳米羟基磷灰石复合材料及其在骨组织修复领域中的研究进展做简要综述。

关键词: 纳米羟基磷灰石复合材料, 骨组织修复, 有机材料, 无机材料

Abstract: As the nano-hydroxyapatite is the main inorganic component of bone tissue of the human body, artificial synthesis of nano-hydroxyapatite has attracted the most attention in the field of hard tissue repair. To make up multiple aspects of limitations for nano-hydroxyapatite material itself, nano-hydroxyapatite complexes have been widely evaluated and applied in bone repair. This paper reviewed the common nano-hydroxyapatite complexes and their research progress in bone regeneration. Supported by Research Fund of Science and Technology Committee of Shanghai Municipality (12NM0501600, 13NM1402102) and Medicine and Engineering Cross Project of Shanghai Jiao Tong University (YG2012MS29).

Key words: Nano-hydroxyapatite composite, Bone tissue regeneration, Organic materials, Inorganic materials

中图分类号:

R782

周宇宁, 夏伦果, 徐袁瑾. 复合纳米羟基磷灰石材料在骨组织修复领域中的研究进展[J]. 上海口腔医学, 2014, 23(2): 248-252.

ZHOU Yu-ning, XIA Lun-guo, XU Yuan-jin. Research progress of nano-hydroxyapatite complexes in bone tissue regeneration[J]. Shanghai Journal of Stomatology, 2014, 23(2): 248-252.

参考文献

[1] Zhu X, Eibl O, Scheideler L, et al. Characterization of nano hydroxyapatite/collagen surfaces and cellular behaviors [J]. J Biomed Mater Res A, 2006, 79(1): 114-127.
[2] Fukui N, Sato T, Kuboki Y, et al. Bone tissue reaction of nano-hydroxyapatite/collagen composite at the early stage of implantation [J]. Biomed Mater Eng, 2008, 18(1): 25-33.
[3] Palazzo B, Gallo A, Casillo A, et al. Fabrication, characterization and cell cultures on a novel composite chitosan-nano-hydroxyapatite scaffold [J]. Int J Immunopathol Pharmacol, 2011, 24(1 Suppl 2): 73-78.
[4] Chesnutt BM, Yuan Y, Buddington K, et al. Composite chitosan/nano-hydroxyapatite scaffolds induce osteocalcin production by osteoblasts in vitro and support bone formation in vivo[J]. Tissue Eng Part A, 2009, 15(9): 2571-2579.
[5] Teng S, Chen L, Guo Y, et al. Formation of nano-hydroxyapatite in gelatin droplets and the resulting porous composite microspheres [J]. J Inorg Biochem, 2007, 101(4): 686-691.
[6] Dou XC, Li QL, Zhou J, et al. Biomimetic synthesis of a novel antibacterial nano-composite materials of hydroxyapatite and gelatin for bone repair and its biocompatibility in vitro [J]. Shanghai Kou Qiang Yi Xue, 2010, 19(3): 285-289.
[7] Huang M, Feng J, Wang J, et al. Synthesis and characterization of nano-HA/PA66 composites [J]. J Mater Sci Mater Med, 2003, 14(7): 655-660.
[8] Wang H, Li Y, Zuo Y, et al. Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering[J]. Biomaterials, 2007, 28(22): 3338-3348.
[9] Fang L, Leng Y, Gao P. Processing and mechanical properties of HA/UHMWPE nanocomposites [J]. Biomaterials, 2006, 27(20): 3701-3707.
[10] Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering [J]. Biomaterials, 2004, 25(19): 4749-4757.
[11] Hong Z, Zhang P, He C, et al. Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility [J]. Biomaterials, 2005, 26(32): 6296-6304.
[12] 王世革. 锂皂石或羟基磷灰石掺杂的静电纺纳米纤维的生物医学应用研究 [D]. 上海: 东华大学, 2013: 9-125.
[13] Wang DX, He Y, Bi L, et al. Enhancing the bioactivity of Poly (lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model [J]. Int J Nanomedicine, 2013, 8: 1855-1865.
[14] Heo SJ, Kim SE, Wei J, et al. In vitro and animal study of novel nano-hydroxyapatite/poly (epsilon-caprolactone) composite scaffolds fabricated by layer manufacturing process [J].Tissue Eng Part A, 2009, 15(5): 977-989.
[15] 王林, 孙清杰, 翁履谦, 等. 纳米羟基磷灰石粉体及其与 PEEK 复合材料的制备 [J]. 材料开发与应用, 2006, 21(4): 33-37.
[16] 倪卓, 田生礼, 王应, 等. PEEK/HA复合材料热稳定性及细胞毒性试验 [J]. 生物骨科材料与临床研究, 2012, 9(4): 9-12.
[17] Fu S, Ni P, Wang B, et al. In vivo biocompatibility and osteogenesis of electrospun poly (ε-caprolactone)epoly(ethylene glycol)epoly(ε-caprolactone)/nano-hydroxyapatite composite scaffold [J]. Biomaterials, 2012, 33(33): 8363-8371.
[18] Wang F, Zhang YC, Zhou H, et al. Evaluation of in vitro and in vivo osteogenic differentiation of nano-hydroxyapatite/chitosan/poly(lactide-co-glycolide) scaffolds with human umbilical cord mesenchymal stem cells [J]. J Biomed Mater Res A, 2014, 102(3):760-768.
[19] Kokubo T, Kim HM, Kawashita M. Novel bioactive materials with different mechanical properties[J]. Biomaterials, 2003, 24(13): 2161-2175.
[20] Wepener I, Richter W, van Papendorp D, et al. In vitro osteoclast-like and osteoblast cells' response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering[J]. J Mater Sci Mater Med, 2012, 23(12): 3029-3040.
[21] Reddy S, Wasnik S, Guha A, et al. Evaluation of nano-biphasic calcium phosphate ceramics for bone tissue engineering applications: in vitro and preliminary in vivo studies [J]. J Biomater Appl, 2013, 27(5): 565-575.
[22] Chen Z, Liu H, Liu X, et al. Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties [J].J Biomed Mater Res A, 2011, 99(4): 554-563.
[23] Liu X, Liu HY, Lian X, et al. Osteogenesis of mineralized collagen bone graft modified by PLA and calcium sulfate hemihydrate: in vivo study[J]. J Biomater Appl, 2013, 28(1):12-19.
[24] Zhou S, Ma J, Shen Y, et al. In vitro studies of calcium phosphate silicate bone cements [J]. J Mater Sci Mater Med, 2013, 24(2): 355-364.
[25] Zhao D, Huang W, Rahaman MN, et al. Mechanism for converting Al2O3-containing borate glass to hydroxyapatite in aqueous phosphate solution[J].Acta Biomater, 2009, 5(4):1265-1273.
[26] Webster TJ, Siegel RW, Bizios R. Design and evaluation of nanophase alumina for orthopaedic/dental applications [J]. Nanostruct Mater, 1999, 12(5-8): 983-986.
[27] Tripathi G, Gough JE, Dinda A, et al. In vitro cytotoxicity and in vivo osseointergration properties of compression-molded HDPE-HA-Al2O3 hybrid biocomposites [J]. J Biomed Mater Res A, 2013, 101(6): 1539-1549.
[28] Brook I, Freeman C, Grubb S, et al. Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite(Sr-HA) for load-bearing applications[J]. J Biomater Appl, 2012, 27(3): 291-298.
[29] Will J, Hoppe A, Müller FA, et al. Bioactivation of biomorphous silicon carbide bone implants [J]. Acta Biomater, 2010, 6(12): 4488-4494.
[30] Hesaraki S, Ebadzadeh T, Ahmadzadeh-Asl S. Nanosilicon carbide/hydroxyapatite nanocomposites: structural, mechanical and in vitro cellular properties [J]. J Mater Sci Mater Med, 2010, 21(7): 2141-2149.
[31] Nie L, Chen D, Suo J, et al. Physicochemical characterization and biocompatibility in vitro of biphasic calcium phosphate/polyvinyl alcohol scaffolds prepared by freeze-drying method for bone tissue engineering applications[J]. Colloids Surf B Biointerfaces, 2012, 100: 169-176.
[32] Linh NT, Lee KH, Lee BT. Functional nanofiber mat of polyvinyl alcohol/gelatin containing nanoparticles of biphasic calcium phosphate for bone regeneration in rat calvaria defects [J]. J Biomed Mater Res A, 2013, 101(8): 2412-2423.
[33] Huang Y, Zhou G, Zheng L, et al. Micro-/nano- sized hydroxyapatite directs differentiation of rat bone marrow derived mesenchymal stem cells towards an osteoblast lineage [J]. Nanoscale, 2012, 4(7): 2484-2490.
[34] Liu X, Lin K, Wu C, et al. Multilevel hierarchically ordered artificial biomineral [J]. Small, 2014, 10(1):152-159.