上海口腔医学

上海口腔医学 ›› 2023, Vol. 32 ›› Issue (1): 47-51.doi: 10.19439/j.sjos.2023.01.009

• 论著 • 上一篇    下一篇

龈沟液中sICAM-1、IL-1β和HIF-1α水平与义齿种植修复并发种植体周围炎的关系

谢雪梅1, 张佳园2,3, 张野1, 俞晓佳1, 刘李明1, 王健1, 于德栋2   

  1. 1.上海市奉贤区奉城医院 口腔科,上海 201411;
    2.上海交通大学医学院附属第九人民医院 口腔第二门诊部,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 201999;
    3.杭州医学院存济口腔医学院,杭州医学院附属口腔医院,浙江 杭州 310012
  • 收稿日期:2022-08-12 修回日期:2022-09-23 出版日期:2023-02-25 发布日期:2023-06-12
  • 通讯作者: 于德栋,E-mail：yudedong@sjtu.edu.cn
  • 作者简介:谢雪梅（1981-）,女,硕士,副主任医师,E-mail：8316255@qq.com
  • 基金资助:
    国家自然科学基金（52175422）; 上海交通大学医学院附属第九人民医院交叉基金（JYJC202114）; 上海交通大学医学院附属第九人民医院基础研究助推计划（JYZZ145）

Relationship between sICAM-1, IL-1β and HIF-1α levels in gingival sulcus fluid and peri-implantitis in patients with implant restoration

XIE Xue-mei1, ZHANG Jia-yuan2,3, ZHANG Ye1, YU Xiao-jia1, LIU Li-ming1, WANG Jian1, YU De-dong2   

  1. 1. Department of Dentistry, Fengcheng Hospital, Fengxian District. Shanghai 201411;
    2. Department of 2nd Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 201999;
    3. Hangzhou Medical College Cunji College of Stomatology; Affiliated Stomatological Hospital of Hangzhou Medical College. Hangzhou 310012, Zhejiang Province, China
  • Received:2022-08-12 Revised:2022-09-23 Online:2023-02-25 Published:2023-06-12

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摘要： 目的: 探讨龈沟液中可溶性细胞间黏附分子1（sICAM-1）、白细胞介素1β（IL-1β）和缺氧诱导因子1α（HIF-1α）水平与义齿种植修复并发种植体周围炎（PI）的关系。方法: 选择2019年1月—2021年12月奉城医院收治的198例义齿种植修复患者,根据义齿种植修复3个月后是否并发PI将患者分为PI组和非PI组。采用酶联免疫吸附法检测义齿种植修复前龈沟液中sICAM-1、IL-1β和HIF-1α水平。多因素Logistic回归分析并发PI的影响因素,ROC曲线分析龈沟液中sICAM-1、IL-1β和HIF-1α水平对义齿种植修复并发PI的预测价值。采用SPSS 28.0软件包对数据进行统计学处理。结果: 义齿种植修复后3个月,198例患者PI发生率为17.68%（35/198）。PI组龈沟液中sICAM-1、IL-1β和HIF-1α水平显著高于非PI组（P<0.05）。多因素Logistic回归分析显示,sICAM-1（OR=1.135,95%CI：1.066~1.208）、IL-1β（OR=1.106,95%CI：1.054~1.161）和HIF-1α（OR=1.008,95%CI：1.004~1.012）升高为义齿种植修复并发PI的独立危险因素（P<0.05）。ROC曲线分析显示,龈沟液中sICAM-1、IL-1β和HIF-1α水平单独与联合预测义齿种植修复并发PI的曲线下面积分别为0.787、0.785、0.794和0.930,灵敏度分别为80.00%、74.29%、62.86%和88.57%,特异度分别为66.87%、74.85%、78.53%和85.28%。结论: 龈沟液中sICAM-1、IL-1β和HIF-1α水平升高为义齿种植修复并发PI的独立危险因素,可作为义齿种植修复并发PI的辅助预测指标。

关键词: 义齿种植修复, 种植体周围炎, 可溶性细胞间黏附分子1, 白细胞介素1β, 缺氧诱导因子1α

Abstract: PURPOSE: To investigate the relationship between the levels of soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-1β (IL-1β) and hypoxia-inducible factor-1α (HIF-1α) in gingival sulcus fluid and peri-implantitis (PI) in patients with implant restoration. METHODS: A total of 198 patients with implant restoration admitted to Fengcheng Hospital from January 2019 to December 2021 were selected, the patients were divided into PI and non-PI group according to whether the implant restoration was complicated by PI 3 months after restoration. The levels of sICAM-1, IL-1β and HIF-1α in the gingival sulcus fluid prior to implant restoration were measured by enzyme-linked immunosorbent assay. Multi-factor logistic regression was used to analyze the factors influencing concurrent PI in patients with implant restoration. ROC curves were used to analyze the predictive value of sICAM-1, IL-1β and HIF-1α levels in gingival sulcus fluid on concurrent PI in patients with implant restoration. SPSS 28.0 software package was used for statistical processing of the data. RESULTS: The incidence of PI in 198 patients with implant restoration was 17.68% (35/198) 3 months after implant restoration. The levels of sICAM-1, IL-1β and HIF-1α in the gingival sulcus fluid were significantly higher in the PI group than in the non-PI group (P<0.05). Multi-factor logistic regression analysis showed that elevated sICAM-1(OR=1.135, 95%CI: 1.066 to 1.208), IL-1β (OR=1.106, 95%CI: 1.054 to 1.161) and HIF-1α (OR=1.008, 95%CI: 1.004 to 1.012) were independent risk factors for complications of PI in prosthetic patients(P<0.05). ROC curve analysis showed that the area under the curve for sICAM-1, IL-1β and HIF-1α levels in gingival sulcus fluid alone and in combination for the diagnosis of concurrent PI in patients with implantation was 0.787, 0.785, 0.794 and 0.930, respectively, with sensitivity of 80.00%, 74.29%, 62.86% and 88.57% and specificity of 66.87%, 74.85%, 78.53% and 85.28%, respectively. CONCLUSIONS: Elevated levels of sICAM-1, IL-1β and HIF-1α in gingival sulcus fluid are independent risk factors for PI complications in patients with implant restoration and can be used as an auxiliary predictor of PI complications in patients with implant restoration.

Key words: Dental implant restoration, Peri-implantitis, Soluble intercellular adhesion molecule 1, Interleukin-1β, Hypoxia-inducible factor-1α

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