注射型富血小板纤维蛋白在上颌窦外提升术中的应用效果

doi:10.19439/j.sjos.2019.01.014

摘要/Abstract

摘要： 目的:评价注射型富血小板纤维蛋白（injectable-platelet rich fibrin,I-PRF）在上颌窦外提升术中促进成骨的效果。方法:选取2014年6月—2015年6月就诊于江苏省常州市口腔医院种植科,上颌后部磨牙或前磨牙单颗缺失可用骨高度3~5 mm,需进行上颌窦外提升的患者46例,随机分为2组,A组窦底填塞Bio-oss骨粉,B组窦底填塞Bio-oss骨粉+ I-PRF混合物。拍摄锥形束CT（CBCT）,于术前测量剩余骨高度（residual bone height,RBH）,术后即刻、术后6个月、术后12个月测量新生骨高度（new formed bone height,NFBH）,并于术后4个月进行二期手术,术后6个月修复时测量ISQ值,比较2组成骨效果。采用SPSS 20.0软件包对数据进行统计学分析。结果:46例患者伤口均一期愈合,无感染、裂开等。CBCT检查显示,术前、术后12个月2组间RBH比较差异无统计学意义（P>0.05）,术后即刻、术后6个月,A组RBH显著高于B组（P<0.05）。术后4个月,A组ISQ值显著高于B组（P<0.05）,而术后6个月2组ISQ值无显著差异（P>0.05）。结论:I-PRF在上颌窦底外提升术中安全可靠,能够有效缩短愈合时间,增强成骨效果。

关键词: 上颌窦外提升, 注射型富血小板纤维蛋白, 骨再生

Abstract: PURPOSE: The aim of the present research was to evaluate the regeneration effect of injectable-platelet rich fibrin (I-PRF) in lateral sinus lift. METHODS: A total of 46 cases, who lost their single posterior tooth with residual bone height of 3-5 mm, who needed lateral sinus lift, were treated in our hospital for implantation from June 2014 to Jun 2015. They were randomly divided into 2 groups. In group A, Bio-oss was used as a sole grafting material to fill the sinus; in group B, Bio-oss was used in combination with I-PRF to fill the sinus. Cone-beam CT (CBCT) was taken preoperatively, the residual bone height (RBH) was measured. The new formed bone height (NFBH) was measured immediately, 6 months and 12 months after surgery. ISQ values of implants were taken 4 months, 6 months postoperatively. SPSS 20.0 software was used for statistical analysis. RESULTS: All cases achieved primary healing, no infection or dehiscence was found. No significant difference of the RBH and NFBH was found between pre-operation or 12 months postoperatively, while significant difference was found immediately and 6 months postoperatively. The value of ISQ in group A was significantly higher than that in group B at 4 months(P<0.05), and there was no significant difference between 2 groups 6 months after operation(P>0.05). CONCLUSIONS: I-PRF is a safe and reliable material in sinus lift, which can effectively shorten the healing time and enhance the effect of osteogenesis.

Key words: Lateral sinus lift, Injectable-platelet rich fibrin, Bone regeneration

中图分类号:

R782.1

谢慧, 解永富, 刘勤, 商玲燕, 陈敏箴. 注射型富血小板纤维蛋白在上颌窦外提升术中的应用效果[J]. 上海口腔医学, 2019, 28(1): 71-75.

XIE Hui, XIE Yong-fu, LIU Qin, SHANG Ling-yan, CHEN Min-zhen. Bone regeneration effect of injectable-platelet rich fibrin (I-PRF) in lateral sinus lift: a pilot study[J]. Shanghai Journal of Stomatology, 2019, 28(1): 71-75.

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