Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus

Abstract

Abstract: PURPOSE: To investigate the expression of Treg and IL-15 in the peripheral blood of patients with oral lichen planus (OLP). METHODS: The peripheral blood was obtained from 36 OLP patients and 20 healthy controls. Flow cytometry was used to evaluate the proportion of Treg cells, and the level of IL-15 was measured by ELISA. The data were analyzed by SPSS 16.0 software package. RESULTS: In the peripheral blood of OLP patients, the proportion of CD4⁺CD25⁺Foxp3⁺ Treg cells and IL-15 content were significantly higher than those of the healthy controls (P<0.05), but there were no significantly difference between two clinical subtypes of OLP(P>0.05). The proportion of CD4⁺CD25⁺Foxp3⁺Treg cells was positively correlated with the level of IL-15(r=0.70,P<0.05). CONCLUSIONS: The high expression of Treg cells and IL-15 in the perpheral blood of OLP patients may be responsible for the pathogenesis of OLP.

Key words: Oral lichen planus, Treg, IL-15

CLC Number:

R781.5

WANG Cui-jie, LI Yan-jun, XUE Jiang-nan, CI Hao-su, LI Li-ping, LI Ling. Correlation of Treg and IL-15 expression in the peripheral blood of patients with oral lichen planus[J]. Shanghai Journal of Stomatology, 2016, 25(4): 438-442.

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