Drug release from electrospun simvastatin/polycaprolactone fibrous membranes

Abstract

Abstract: PURPOSE: To prepare electrospun simvastatin/polycaprolactone(SMV/PCL) membrane scaffolds and to evaluate the release properties of this formulation. METHODS: Electrospun SMV/PCL membrane scaffolds were prepared as the experimental group, and electrospun PCL membrane as the control group. The morphology and characteristics of membrane surface were determined by scanning electron microscopic(SEM) and X-ray diffraction(XRD). The release profile of SMV was determined using an ultraviolet-visible spectrometer. The data were analyzed statistically with SPSS 17.0 software package. RESULTS: SEM and XRD indicated that SMV/PCL nanofibers were successfully electrospun and SMV was encapsulated into the fibers. In vitro drug release studies showed that simultaneous SMV release, being nearly linear with time, was achieved and sustained SMV release was prolonged to 28 days. CONCLUSIONS: Electrospun SMV/PCL nanofiber membranes demonstrate sustained drug release properties, suggesting their potential applicability as prospective scaffolds in periodontal regeneration.

Key words: Electrospinning, Simvastatin, Controlled release, Periodontal regeneration

CLC Number:

R783.1

ZHAO Bing-jiao, XU Yao, LIU Yue-hua. Drug release from electrospun simvastatin/polycaprolactone fibrous membranes[J]. Shanghai Journal of Stomatology, 2016, 25(6): 673-677.

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