Abstract: PURPOSE: To evaluate the effect of N₂O inhalation and oral midazolam sedation on uncooperative patients with intellectual disability in pediatric dentistry. METHODS: N₂O inhalation(35%-50%) and oral midazolam conscious sedation(dosages range: 0.50-0.75 mg/kg) were applied to 67 uncooperative pediatric patients with intellectual disability in outpatient department. The patients were divided into 2 groups: group A(N₂O inhalation conscious sedation)and group B(oral midazolam conscious sedation).Treatment results and safety were statistically analyzed by Chi-square test with SPSSl3.0 software package. RESULTS: The mean success rate was 70%. The success rate in group B (75%) was higher than group A (67%). The overall incidence of adverse reactions was 13%(9/67). The adverse reaction rate in group B (25%) was significantly higher than group A(5%, P<0.05). CONCLUSIONS: N₂O inhalation and oral midazolam conscious sedation are effective and safe in pediatric dental uncooperative patients with intellectual disability .

Key words: N2O, Midazolam, Pediatric dentistry, Intellectual disability