Shanghai Journal of Stomatology

Shanghai Journal of Stomatology ›› 2022, Vol. 31 ›› Issue (2): 189-192.doi: 10.19439/j.sjos.2022.02.014

• Original Articles • Previous Articles     Next Articles

The effect of four immunosuppressive drugs on oral manifestations after organ transplantation

ZHAO Wen-jiao1,2, JIN Ya-feng3, LYU Ke-jia1, YAN Duo-duo3, YAO Hua1   

  1. 1. Department of Stomatology, The First Affiliated Hospital, College of Medicine,Zhejiang University. Hangzhou 310003;
    2. Department of Stomatology, The Second People's Hospital of Yuhang District. Hangzhou 311121;
    3. Department of Stomatology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College. Hangzhou 310022, Zhejiang Province, China
  • Received:2020-07-27 Revised:2021-10-22 Online:2022-04-25 Published:2022-05-16

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Abstract: PURPOSE: To assess the prevalence of oral manifestations in a group of allogenic liver, kidney or haematopoietic stem cell transplantation recipients and patients, and analyze the possible oral manifestations associated with the use of 4 immunosuppressive drugs. METHODS: One hundred and eighteen patients submitted to liver, kidney and hematopoietic stem cell transplantation who used tacrolimus, sirolimus,cyclosporine or mycophenolate mofetil were enrolled. Through a questionnaire survey and oral examination, their oral manifestations were recorded, and the possible statistical associations with immunosuppressive drugs were analyzed using SPSS 21.0 software package. RESULTS: The prevalence of oral lichenoid lesions and cheilitis for the group of patients using tacrolimus after transplantation was significantly lower than the group of patients who did not used the agent(P<0.01). The prevalence of oral lichenoid lesions for the group of patients who used cyclosporine was significantly higher than the group of patients who did not used the drug(P<0.05), and the prevalence of cheilitis for the group of patients who used cyclosporine was significantly higher than the group of patients who did not used the drug(P<0.01). The prevalence of oral lichenoid lesions and cheilitis for the group of patients who used tacrolimus was significantly lower than the group of patients who used cyclosporine(P<0.01). The group of patients who used mycophenolate mofetil after transplantation had a significantly lower prevalence of dry mouth than the group of patients who did not used the drug(P<0.01). The prevalence of oral manifestations in patients with sirolimus after transplantation was not significantly reduced. CONCLUSIONS: The use of tacrolimus improved the symptoms of oral lichenoid lesions and cheilitis and the effect was better than cyclosporine after transplantation. The use of mycophenolate mofetil improved dry mouth after organ transplantation.

Key words: Oral lichenoid lesions, Cheilitis, Dry mouth, Organ transplantation, Tacrolimus, Cyclosporine, Mycophenolate mofetil

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