Shanghai Journal of Stomatology ›› 2021, Vol. 30 ›› Issue (6): 654-657.doi: 10.19439/j.sjos.2021.06.018

• Original Articles • Previous Articles     Next Articles

Effect of ibuprofen administration for preemptive analgesia on recovery quality after palatoplasty in infants

PENG Zhe-zhe, SUN Ying, ZHANG Ma-zhong, ZHENG Ji-jian, WANG Yan-ting   

  1. Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine. Shanghai 200127, China
  • Received:2021-05-18 Revised:2021-08-10 Published:2022-03-09

Abstract: PURPOSE: To evaluate the effect of ibuprofen injection on the quality of postoperative anesthesia for infants who received palatoplasty. METHODS: Patients were induced with 8 % sevoflurane in oxygen(8 L/min), followed by intravenous catheterization. Tracheal intubation was facilitated intravenously with atropine 0.01 mg/kg, propofol 2 mg/kg, fentanyl 2 μg/kg, and rocuronium 0.6 mg/kg. Anesthesia was maintained with 1-2 minimum alveolar concentration sevoflurane in oxygen and air until the end of surgery. Forty-six patients with cleft palate were randomly divided into ibuprofen injection group (Group A) and control group (Group B) with 23 patients in each group. Patients in group A received a single dose of 10 mg/kg ibuprofen intravenously and patients in group B received normal saline in 10 min after induction. The patients were transferred to postanesthesia care unit (PACU) after tracheal extubation. The operation time, spontaneous respiration recovery time and extubation time were recorded. FLACC score and PAED score were recorded immediately (T0), 10 min(T1), 20 min(T2), and 30 min(T3) after arrival at PACU. Fentanyl was injected slowly at 1 μg/kg for treatment of severe pain or severe delirium which lasted over 5 min. Perioperative adverse events were also recorded. Statistical analysis was performed using SAS 9.1 software. RESULTS: There was no significant difference in operation time, spontaneous respiratory recovery time and extubation time between the two groups(P>0.05), but there was significant difference in FLACC score between the two groups at T0 to T2(P<0.05). PAED score was significantly different between the two groups at all observation time point (P<0.05). Four(18%) patients in Group A and 9(43%) patients in group B received fentanyl treatment, the difference was significant(P<0.05). One patient from Group B presented SpO2<93% after treatment with fentanyl. Hypoxia was relieved after persistent oxygen therapy without prolongation of observation time in PACU. CONCLUSIONS: Injection of ibuprofen for infants after induction does not affect spontaneous respiratory recovery time and extubation time. In addition, the application contribute to pain and agitation relief in PACU without adverse events.

Key words: Cleft palate, Ibuprofen, Injection, Analgesia

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