Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial

doi:10.19439/j.sjos.2023.03.015

Shanghai Journal of Stomatology ›› 2023, Vol. 32 ›› Issue (3): 298-301.doi: 10.19439/j.sjos.2023.03.015

• Original Articles • Previous Articles Next Articles

Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial

ZHAO Jun^1,2,3, WU Xiao-bo^2,3, LIU Na⁴, ZHOU Yu⁵, HAO Xin-he^1,2,3

1. Department of Oral and Maxillofacial Surgery, Hefei Stomatology Hospital. Hefei 230001;
2. Hefei Clinical School of Stomatology, Anhui Medical University. Hefei 230001;
3. The Fifth Clinical College of Medicine, Anhui Medical University. Hefei 230022;
4. Department of Oral Medicine, The First Affiliated Hospital of Anhui Medical University. Hefei 230022;
5. Department of Oral Medicine, The First Affiliated Hospital of University of Science and Technology of China. Hefei 230001, Anhui Province, China

Received:2022-12-22 Revised:2023-02-09 Online:2023-06-25 Published:2023-06-28

Abstract

Abstract: PURPOSE: To study the preemptive analgesic effect of dexketoprofen tromethamine in extraction of impacted teeth. METHODS: Twenty patients with bilateral mandibular impacted teeth were selected, and were randomly divided into dexketoprofen tromethamine group(experimental group) and placebo group(control group). The pain scores of patients at 0.5, 2, 4, 8, 12, and 24 hours after tooth extraction were counted by numeric rating scale(NRS), and the total dosage of emergent analgesic drugs used in 24 hours was recorded. COX analysis method was used to compare the interval time and the number of cases of first application of emergent analgesic drugs after two operations, and the survival curve was drawn. SPSS 20.0 software package was used for data analysis. RESULTS: The NRS scores of postoperative pain in the experimental group were significantly lower than those in the control group at 2, 4, 8 and 12 hours after operation (P<0.05). The dose of emergent analgesics used in the experimental group for 24 h was significantly lower than that in the control group (P<0.05). Survival curve showed that the interval time between the first application of analgesics in the experimental group was significantly longer than that in the control group(P<0.05). CONCLUSIONS: Dexketoprofen tromethamine can achieve obvious analgesic effect within 12 hours, but the analgesic effect is not obvious after 12 hours.

Key words: Dexketoprofen tromethamine, Extraction of impacted teeth, Preemptive analgesia, Numeric rating scale

CLC Number:

R782.1

ZHAO Jun, WU Xiao-bo, LIU Na, ZHOU Yu, HAO Xin-he. Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial[J]. Shanghai Journal of Stomatology, 2023, 32(3): 298-301.

References

[1] Warraich R, Faisal M, Rana M, et al.Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone-a randomized observer blind prospective study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 116(1): 16-22.
[2] Kazancioglu HO, Kurklu E, Ezirganli S.Effects of ozone therapy on pain, swelling, and trismus following third molar surgery[J]. Int J Oral Maxillofac Surg, 2014, 43(5): 644-648.
[3] Slade GD, Foy SP, Shugars DA,et al.The impact of third molar symptoms, pain, and swelling on oral health-related quality of life[J]. J Oral Maxillofac Surg, 2004, 62(9): 1118-1124.
[4] 毛旭,胡开进,张新庆,等.牙科畏惧症在经历拔牙术患者中的流行状况研究[J].实用口腔医学杂志, 2016, 32(5): 705-707.
[5] Cho H, Lynham AJ, Hsu E.Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence[J]. Aust Dent J, 2017, 62(4): 412-419.
[6] Albuquerque AFM, Fonteles CSR, do Val DR, et al. Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study[J]. Int J Oral Maxillofac Surg, 2017, 46(12): 1615-1625.
[7] Manfredi M, Figini L, Gagliani M, et al. Single versus multiple visits for endodontic treatment of permanent teeth[J]. Cochrane Database Syst Rev, 2016, 12(12): CD005296.
[8] Stromer W, Michaeli K, Sandner-Kiesling A.Perioperative pain therapy in opioid abuse[J]. Eur J Anaesthesiol, 2013, 30(2): 55-64.
[9] Woolf CJ, Chong MS.Preemptive analgesia-treating postoperative pain by preventing the establishment of central sensitization[J].Anesth Analg,1993, 77(2): 362-379.
[10] Austin PJ, Moalem-Taylor G.The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines[J]. J Neuroimmunol, 2010, 229(1-2): 26-50.
[11] Deumens R, Steyaert A, Forget P, et al.Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches[J]. Prog Neurobiol, 2013, 104: 1-37.
[12] Fitzpatrick FA.Cyclooxygenase enzymes: regulation and function[J]. Curr Pharm Des, 2004, 10(6): 577-588.
[13] 谢龙,李智.依托考昔超前镇痛对阻生牙拔除术后疼痛的影响[J].中华口腔医学杂志, 2021,56(6): 565-569.
[14] Isola G, Alibrandi A, Pedullà E, et al.Analysis of the effectiveness of lornoxicam and flurbiprofen on management of pain and sequelae following third molar surgery: a randomized, controlled, clinical trial[J]. J Clin Med, 2019, 8(3): 325-338.
[15] Landim FS, Laureano Filho JR, Nascimento J, et al.Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial[J]. Int J Oral Maxillofac Surg, 2020,49(11): 1508-1507.
[16] 关明,王恩博,崔念晖,等.拔牙术中氟比洛芬酯超前镇痛的作用[J].中华口腔医学杂志,2013,48(9): 554-555.
[17] Seymour RA, Meechan JG, Blair GS.An investigation into post-operative pain after third molar surgery under local analgesia[J]. Br J Oral Maxillofac Surg, 1985, 23(6): 410-418.
[18] Costa FW, Soares EC, Esses DF, et al.A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars[J]. Int J Oral Maxillofac Surg, 2015, 44(9):1166-1174.
[19] Steinmeyer J.Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs[J]. Arthritis Res, 2000, 2(5): 379-385.
[20] 杨晓燕, 龚培力, 沈霖, 等. 右旋酮洛芬氨丁三醇和酮洛芬双盲对照治疗类风湿关节炎[J].中国新药杂志, 2003, 12(4): 291-295.
[21] 蒋明华, 陆东庆. 右旋酮洛芬氨丁三醇治疗带状疱疹神经痛疗效观察[J].中国皮肤性病学杂志, 2009, 23(6): 355-356.
[22] Erdil A, Akbulut N, Altan A, et al.Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial[J]. Clin Oral Investig, 2021, 25(4): 1849-1857.

Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial

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