Association between IL-10-1082G/A gene polymorphism and susceptibility of recurrent oral ulcer: meta analysis

doi:10.19439/j.sjos.2018.05.023

Abstract

Abstract: PURPOSE: To systematically review the association between interleukin-10 (IL-10) -1082G/A gene polymorphism and susceptibility of recurrent oral ulcer (ROU) by meta analysis. METHODS: Databases of PubMed, Embase, Web of Science, CNKI, CBM, WanFang, and VIP were electronically searched to collect studies published up to August 2017 about the association between IL-10-1082G/A gene polymorphism and ROU susceptibility. According to the inclusion and exclusion criteria, two reviewers independently screened literature and extracted data, the methodological quality assessment and heterogeneity test of included studies were performed. Meta analysis was performed with RevMan5.3 software. RESULTS: A total of 6 case-control studies were included, which involved 668 ROU patients in case group and 769 healthy individuals in control group. In the general population, the results of meta analysis showed that, under 3 genetic models including allele model (G vs A), recessive model (GG+GA vs AA) and heterozygous model (GA vs AA), there was significant association between IL-10-1082G/A gene polymorphism and ROU susceptibility (G vs A: OR=1.31, 95%CI 1.03 to 1.66, P=0.03; GG+GA vs AA: OR=1.45, 95%CI 1.16 to 1.82, P=0.001; GA vs AA: OR= 1.33, 95%CI 1.04 to 1.70, P=0.02). In the Asian population, meta analysis result was consistent with the general population. CONCLUSIONS: IL-10-1082G/A gene polymorphism is associated with ROU susceptibility. Individuals with G allele and GA genotype have a higher risk of ROU. Future more well-designed, large sample and multicenter studies are greatly needed to verify our conclusion.

Key words: Recurrent oral ulcer, Interleukin-10, Gene polymorphism, Meta analysis

CLC Number:

R781.5

DU Quan-gao, XU Ya-mei, WU Ting-ting, FU Gang. Association between IL-10-1082G/A gene polymorphism and susceptibility of recurrent oral ulcer: meta analysis[J]. Shanghai Journal of Stomatology, 2018, 27(5): 554-560.

References

[1] 张贤梅, 孙勤国. 复发性口腔溃疡发病机制及中西医结合治疗进展[J]. 时珍国医国药, 2013, 24(10): 2495-2497.
[2] Akintoye SO, Greenberg MS.Recurrent aphthous stomatitis[J]. Dent Clin North Am, 2014, 58(2): 281-297.
[3] Slebioda Z, Krawiecka E, Rozmiarek M, et al.Clinical phenotype of recurrent aphthous stomatitis and interleukin-1β genotype in a Polish cohort of patients[J]. J Oral Pathol Med, 2017, 46(8): 657-662.
[4] Jurge S, Kuffer R, Scully C, et al.Mucosal disease series. Number VI. Recurrent aphthous stomatitis[J]. Oral Dis, 2006, 12(1): 1-21.
[5] 张燕, 刘文娟, 王弘轶, 等. 复发性口腔溃疡免疫病因学相关研究[J]. 现代免疫学, 2012, 32(5): 434-437.
[6] 刘好好, 许子悦, 谢春雨, 等. 复发性口腔溃疡与T细胞免疫研究进展[J]. 现代免疫学, 2016, 36(1): 72-75.
[7] 王翠杰, 李言君. 白细胞介素-10与口腔黏膜病相关性的研究进展[J]. 中外医学研究, 2016, 14(14): 163-164.
[8] 张敬, 王婷婷, 漆明. 复发性阿弗他溃疡患者外周血中 TGF -β1 和 IL -10 的表达水平及其临床意义[J].实用口腔医学杂志, 2014, 30(1): 82-84.
[9] Sabat R, Grutz G, Warszawska K, et al.Biology of interleukin-10[J]. Cytokine Growth Factor Rev, 2010, 21(5): 331-344.
[10] 冯祥汝, 陈义龙, 卢强. 白细胞介素10的生物学功能及其在疾病中的作用研究进展[J]. 中国畜牧兽医, 2012, 39(3): 74-77.
[11] Mosser DM, Zhang X.Interleukin-10: new perspectives on an old cytokine[J]. Immunol Rev, 2008, 226: 205-218.
[12] Eskdale J, Kube D, Tesch H, et al.Mapping of the human IL10 gene and further characterization of the 5' flanking sequence[J]. Immunogenetics, 1997, 46(2): 120-128.
[13] Turner DM, Williams DM, Sankara D, et al.An investigation of polymorphism in the interleukin-10 gene promoter[J]. Eur J Immunogenet. 1997, 24(1): 1-8.
[14] Rees LE, Wood NA, Gillespie KM, et al.The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance[J]. Cell Mol Life Sci, 2002, 59(3): 560-569.
[15] Xuan Y, Wang L, Zhi H, et al.Association between 3 IL-10 gene polymorphisms and cardiovascular disease risk: systematic review with meta-analysis and trial sequential analysis[J]. Medicine (Baltimore), 2016, 95(6): e2846.
[16] Peng Z, Lv XL, Sun YF, et al.Association of Interleukin-10 -1082A/G polymorphism with idiopathic recurrent miscarriage: a systematic review and meta-analysis[J]. Am J Reprod Immunol, 2016, 75(2): 162-171.
[17] Koss K, Fanning GC, Welsh KI, et al.Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3' mismatches in forward and reverse primers[J]. Genes Immun, 2000, 1(5): 321-324.
[18] Yilmaz V, Yentur SP, Direskeneli GS, et al.IL-12 and IL-10 polymorphisms and their effects on cytokine production[J]. Cytokine, 2005, 30(4): 188-194.
[19] Stang A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010, 25(9): 603-605.
[20] 张敬, 沙晶晶, 龚娟. 转化生长因子β1和白细胞介素10单核苷酸多态性与复发性口腔溃疡易感性的研究[J]. 华西口腔医学杂志, 2016, 34(1): 27-31.
[21] Najafi S, Moqadam IF, Mohammadzadeh M, et al.Interleukin-10 gene polymorphisms in recurrent aphthous stomatitis[J]. Immun Invest, 2014, 43(4): 405-409.
[22] Jing C, Zhang JQ.Association between interleukin gene polymorphisms and risk of recurrent oral ulceration[J]. Gene Molec Res, 2015, 14(2): 6838-6843.
[23] Sun M, Fu SM, Dong GY, et al.Inflammatory factors gene polymorphism in recurrent oral ulceration[J]. J Oral Pathol Med, 2013, 42(7): 528-534.
[24] Guimarães AL, Correia-Silva Jde F, Sá AR, et al. Investigation of functional gene polymorphisms IL-1β, IL-6, IL-10 and TNF-α in individuals with recurrent aphthous stomatitis[J]. Arch Oral Bio, 2007, 52(3): 268-272.
[25] Bazrafshani MR, Hajeer AH, Ollier WE, et al.Polymorphisms in the IL-10 and IL-12 gene cluster and risk of developing recurrent aphthous stomatitis[J]. Oral Dis, 2003, 9(6): 287-291.
[26] Tarakji B, Gazal G, Al-Maweri SA, et al.Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners[J]. J Int Oral Health, 2015, 7(5): 74-80.
[27] Lewcowicz N, Kur B, Kurnatowska A, et al.Expression of Th1/Th2/Th3/Th17-related genes in recurrent aphthous ulcers[J]. Arch Immunol Ther Exp (Warsz), 2011, 59(5): 399-406.
[28] Albanidou-Farmaki E, Markopoulos AK, Kalogerakou F, et al.Detection, enumeration and characterization of T helper cells secreting type 1 and type 2 cytokines in patients with recurrent aphthous stomatitis[J]. Tohoku J Exp Med, 2007, 212(2): 101-105.
[29] Slebioda Z, Szponar E, Kowalska A.Recurrent aphthous stomatitis: genetic aspects of etiology[J]. Postepy Dermatol Alergol, 2013, 30(2): 96-102.