Analysis of the biocompatibility of a new PLGA/fish skin collagen conjugated electrostatic spinning film

doi:10.19439/j.sjos.2018.03.005

Abstract

Abstract: PURPOSE: To study the biocompatibility of a new polylactic acid-glycolic acid(PLGA)/fish skin collagen conjugated electrostatic spinning film. METHODS: PLGA and medical-grade fish skin-I collagen were used as raw materials to prepare nanometer fiber films by conjugated electrostatic spinning technique. Mouse fibroblast L929 was used as a model to evaluate its cell and histocompatibility, which provided experimental basis for application in guided bone regeneration (GBR). RESULTS: Fibroblasts showed good adhesion and growth on the surface of fiber membrane; there were a large number of deep pseudopodias, which were arranged along the orientation of fibers. CONCLUSIONS: PLGA/fish skin collagen conjugated electrostatic spinning membrane is beneficial to fibroblast growth and is expected to be used for GBR.

Key words: Conjugated electrostatic spinning technology, Nanofilms, Biocompatibility, Guided bone regeneration

CLC Number:

R783.1

LU Xiao-li, MIAO Hui-ling, LIU Feng, GAO Mei-qin. Analysis of the biocompatibility of a new PLGA/fish skin collagen conjugated electrostatic spinning film[J]. Shanghai Journal of Stomatology, 2018, 27(3): 244-247.

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