126例口腔颌面部间隙感染患者治疗效果相关影响因素分析

doi:10.19439/j.sjos.2018.05.009

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (5): 491-494.doi: 10.19439/j.sjos.2018.05.009

126例口腔颌面部间隙感染患者治疗效果相关影响因素分析

蒲金霞, 李晨曦, 贺多敏, 林兆全^*, 龚忠诚^*

新疆医科大学第一附属医院口腔医学中心,口腔颌面肿瘤外科,新疆乌鲁木齐 830054

收稿日期:2017-06-30 出版日期:2018-10-25 发布日期:2018-11-05
通讯作者: 林兆全,E-mail:lzqxhj@163.com;龚忠诚,E-mail:gump0904@aliyun.com。^*共同通信作者
作者简介:蒲金霞（1982-）,女,学士,护师,E-mail: 1024098823@qq.com
基金资助:
国家自然科学基金(31260229); 新疆维吾尔自治区青年科技创新人才培养工程项目(2014721046)

Analysis of related factors affecting treatment results in 126 patients with oral and maxillofacial space infection

PU Jin-xia, LI Chen-xi, HE Duo-min, LIN Zhao-quan, GONG Zhong-cheng

Department of Oral and Maxillofacial Oncology Surgery, Stomatological Medical Center, The First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2017-06-30 Online:2018-10-25 Published:2018-11-05

摘要/Abstract

摘要： 目的: 分析影响口腔颌面部间隙感染治疗效果的相关因素。方法: 收集新疆医科大学第一附属医院口腔颌面外科2015—2017年间接受住院治疗的126例口腔颌面部间隙感染患者的一般临床指标（体重指数、发病到入院天数、间隙累及的数量等）、实验室检查指标（白细胞数目、中性粒细胞数目、白介素6、C反应蛋白、降钙素、血糖、血脂及白蛋白等）。采用SPSS20.0软件包对影响因素进行Pearson相关分析,多重线性回归方法分析影响患者住院天数的相关因素。结果: 相关性分析发现,患者住院天数与年龄、白细胞、中性粒细胞、中性粒细胞比、C反应蛋白、体重指数（BMI）、甘油三酯、高密度脂蛋白、间隙累及数量显著相关（P<0.05）;多重线性回归分析发现4个自变量回归系数具有统计学意义（P<0.05）,分别是感染间隙数目、发病至入院天数、甘油三酯、中性粒细胞。结论: 口腔颌面部间隙感染患者住院天数与感染累及间隙数量、甘油三酯、炎症细胞及因子量呈正相关变化趋势,与高密度脂蛋白呈负相关变化趋势。此外,感染间隙数量、发病至入院天数、甘油三酯、中性粒细胞对口腔颌面部间隙感染的治疗结果有显著影响。

关键词: 口腔颌面部间隙, 间隙感染, 危险因素

Abstract: PURPOSE: This study was aimed to retrospectively investigate the related factors of oral and maxillofacial space infection in 126 patients. METHODS: The clinical data of 126 patients with oral and maxillofacial space infection were collected from the Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University during the period of 2015 to 2017. The clinical features (e.g. body mass index, the number of days from onset to hospital admission, and the number of inflammatory spaces, and etc.) as well as laboratory examination variables (e.g. leucocytic count, the number of neutrophilic granulocyte, interleukin-6, C reactive protein, calcitonin, blood glucose, blood lipids, albumin, and etc.). Pearson correlation method were used to analyze the correlated factors and multiple linear regression analysis was used to analyze the related factors with SPSS20.0 software package. RESULTS: Correlation analysis showed that there was a significant correlation in the hospitalization days with the ages, white blood cells, neutrophilic granulocyte, neutrophil ratio, C reactive protein, body mass index, triglyceride, high density lipoprotein, the number of inflammatory spaces. The results of multiple linear regression analysis showed that there were 4 independent variables (P<0.05), which were the number of inflammatory spaces, the number of days from onset to hospital admission, triglyceride and neutrophilic granulocyte. CONCLUSIONS: There was a positive correlation between the hospitalization days with the number of inflammatory spaces, triglyceride, inflammatory cells and cytokines in patients with oral and maxillofacial space infection. In addition, the related factors affecting the treatment results of oral and maxillofacial space infection include the number of inflammatory spaces, the number of days from onset to hospital admission, triglycerides and neutrophils.

Key words: Oral and maxillofacial space, Space infection, Risk factors

中图分类号:

R782.3

蒲金霞, 李晨曦, 贺多敏, 林兆全, 龚忠诚. 126例口腔颌面部间隙感染患者治疗效果相关影响因素分析[J]. 上海口腔医学, 2018, 27(5): 491-494.

PU Jin-xia, LI Chen-xi, HE Duo-min, LIN Zhao-quan, GONG Zhong-cheng. Analysis of related factors affecting treatment results in 126 patients with oral and maxillofacial space infection[J]. Shanghai Journal of Stomatology, 2018, 27(5): 491-494.

参考文献

[1] Kamat RD, Dhupar V, Akkara F, et al.A comparative analysis of odontogenic maxillofacial infections in diabetic and nondiabetic patients: an institutional study[J]. J Korean Assoc Oral Maxillofac Surg, 2015, 41(4): 176-180.
[2] Ricci NA, de Faria Figueiredo Gonçalves D, Coimbra AM, et al. Sensory interaction on static balance: a comparison concerning the history of falls of community-dwelling elderly[J]. Geriatr Gerontol Int, 2009, 9(2): 165-171.
[3] 吴畏, 宗扬勇, 章红勤. C反应蛋白与白细胞计数联合测定在儿童脓疱疮诊疗中的应用[J]. 中医儿科杂志, 2013, 9(3): 27-28.
[4] 孟岑, 颜兴. 口腔颌面部多间隙感染57例的临床分析及治疗[J]. 临床和实验医学杂志, 2015, 14(13): 1076-1079.
[5] 蒋晶晶, 李政. C反应蛋白与白细胞计数、中性粒细胞百分比在口腔颌面部多间隙感染中的应用及比较[J]. 四川解剖学杂志, 2015, 23(1): 6-8.
[6] 樊海燕. 降钙素原在感染性疾病中的应用价值[J]. 现代中西医结合杂志, 2015, 24(1): 89-91.
[7] 谢文锋, 严海燕, 黄松音, 等. 降钙素原在感染性疾病中的临床应用价值[J]. 国际检验医学杂志, 2011, 32(13): 1427-1428.
[8] Zhao GJ, Mo ZC, Tang SL, et al.Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells[J]. Atherosclerosis, 2014, 235(2): 519-525.
[9] De ND, Labzin LI, Kono H, et al.High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3[J]. Nat Immunol, 2014, 15(2): 152-160.
[10] Birner-Gruenberger R, Schittmayer M, Holzer M, et al.Understanding high-density lipoprotein function in disease: recent advances in proteomics unravel the complexity of its composition and biology[J]. Prog Lipid Res, 2014, 56(1): 36-46.
[11] Hu J, Xi D, Zhao J, et al.High-density lipoprotein and inflammation and its significance to atherosclerosis[J]. Am J Med Sci, 2016, 352(4): 408-415.
[12] Sakowicz-Burkiewicz M, Kocbuch K, Grden M, et al.High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes: involvement of P2X7 receptor[J]. Immunobiology, 2013, 218(4): 591-601.
[13] Fraga-Silva TF, Marchetti CM, Mimura LA, et al.Relationship among short and long term of hypoinsulinemia-hyperglycemia, dermatophytosis, and immunobiology of mononuclear phagocytes[J]. Mediators Inflamm, 2015, 2015: 342345.
[14] Jafar N, Edriss H, Nugent K.The Effect of short-term hyperglycemia on the innate immune system[J]. Am J Med Sci, 2016, 351(2): 201-211.
[15] Temming P, Tröger B, Thonnissen S, et al.The effect of hyperglycemia on neonatal immune responses in vitro[J]. J Matern Fetal Neonatal Med, 2012, 25(1): 94-98.

126例口腔颌面部间隙感染患者治疗效果相关影响因素分析

Analysis of related factors affecting treatment results in 126 patients with oral and maxillofacial space infection

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