上海口腔医学

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (5): 579-582.

• 论著 • 上一篇    下一篇

口溃宁颗粒治疗50例复发性口腔溃疡疗效观察

高梦珊1, 刘帅2, 王爱武2   

  1. 1.山东大学口腔医院 山东省口腔组织再生重点实验室,山东 济南 250012；
    2.山东大学附属省立医院 药学部,山东 济南 250021
  • 收稿日期:2015-11-18 修回日期:2016-01-24 出版日期:2016-10-25 发布日期:2016-11-10
  • 通讯作者: 王爱武,E-mail：wangaw66@163.com
  • 作者简介:高梦珊（1979-）,女,药师,E-mail：gms25@sdu.edu.cn

Preparation and clinical observation of Koukuining granules in 50 patients with recurrent aphthous ulcer

GAO Meng-shan1, LIU Shuai2, WANG Ai-wu2   

  1. 1.Stomatological Hospital of Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration. Jinan 250012;
    2.Department of Pharmacy, Provincial Hospital Affiliated to Shandong University. Jinan 250021, Shandong Province, China
  • Received:2015-11-18 Revised:2016-01-24 Online:2016-10-25 Published:2016-11-10

RichHTML

3

被引次数

4

摘要： 目的制备口溃宁颗粒并观察其在50例复发性口腔溃疡（recurrent aphthous ulcer,RAU）患者中的治疗效果。方法以传统中医药理论为指导,处方由黄连、黄芩等纯中药组成,采用湿法制粒工艺制备成口溃宁颗粒。将中医辨证为心火亢盛型RAU且符合标准的100例门诊患者按1∶1比例随机分为治疗组和对照组,治疗组患者饭后口服口溃宁颗粒,每天3次,每次1袋,10 d为1个疗程。1个疗程结束后休息3 d,再服1个疗程;对照组口服维生素C、复合维生素B2,用药2个疗程。观察治疗效果,采用SPSS11.5软件包对数据进行统计学分析。结果该品种制备工艺操作可控,质量稳定,对RAU的治疗总有效率为88.0% ,与对照组相比有显著差异。结论口溃宁颗粒的制备方法简便易行,质量稳定可控,对于心火亢盛型RAU临床疗效确切,有较大的临床应用价值。

关键词: 口溃宁颗粒, 复发性口腔溃疡, 临床疗效

Abstract: PURPOSE: To prepare Koukuining granules and observe its efficiency in the treatment of recurrent aphthas ulce (RAU). METHODS: In accordance with the theories of traditional Chinese medicine, the prescriptions of Koukuining granules were composed of rhizoma coptidis, radix scutellariae and other Chinese herbs, and the preparation procedure was conducted by means of wet granulation technology. One hundred patients with RAU were randomly divided into experimental group and control group equally. Patients in the experimental group took particles orally after a meal, 3 times a day, 1 bag each time, for successive 10 days as one treatment course. The treatment was repeated after 3 days of interval. Patients in the control group took vitamin C, compound vitamin B2, orally for 2 courses. The treatment effect was evaluated. Data analysis was performed using SPSS 11.5 software package. RESULTS: The preparation process was controllable and the quality of the products was stable. The overall effective rate of the experimental group was 88.4% and there was a significant difference compared with the control group. CONCLUSIONS: The preparation of Koukuining granules was feasible with stable quality of final products. Treatment of RAU with the granules was effective and worthy of clinical application.

Key words: Koukuining granules, Recurrent aphthous ulcer, Clinical effect

中图分类号: