上海口腔医学

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (3): 302-304.doi: 10.19439/j.sjos.2017.03.015

• 论著 • 上一篇    下一篇

铁代谢在复发性口腔溃疡患者中的变化及其与细胞免疫功能的关系

蓝余炼, 唐亮, 崔日林   

  1. 广东省深圳市宝安区中心医院 褔中福社康中心,广东 深圳 518102
  • 收稿日期:2016-06-27 修回日期:2016-12-23 出版日期:2017-06-25 发布日期:2017-07-05
  • 通讯作者: 蓝余炼,E-mail: lanyisheng1@163.com
  • 作者简介:蓝余炼（1979-）,女,学士,主治医师
  • 基金资助:
    深圳市宝安区科技社会公益资助项目（2015072）

Study on the changes of iron metabolism in patients with recurrent oral ulcer and its relationship with cellular immune function

LAN Yu-lian, TANG Liang, CUI Ri-lin   

  1. Fuzhongfu Community Health Center, Center Hospital of Baoan District. Shenzhen 518102, Guangdong Province, China
  • Received:2016-06-27 Revised:2016-12-23 Online:2017-06-25 Published:2017-07-05

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被引次数

1

摘要： 目的研究铁代谢异常及细胞免疫功能紊乱与复发性口腔溃疡（recurrent oral ulcer,ROU)的内在联系。方法检测100例ROU患者和100例健康体检人员（对照组）血清铁、铁蛋白及其细胞免疫功能,比较2组间的差异,利用logistic回归分析血清铁蛋白及细胞免疫与复发性口腔溃疡的关系。采用SPSS19.0软件包对数据进行统计学分析。结果ROU组男、女血清铁、铁蛋白、CD3+、CD4+及CD4+/CD8+比值浓度均出现降低,与对照组比较具有显著差异（P<0.01）;多因素logistic回归分析显示,血清铁、铁蛋白及 CD3+、CD4+降低均为ROU发病的独立危险因素（P<0.05）。结论铁缺乏、细胞免疫功能紊乱与ROU发病关系密切。

关键词: 复发性口腔溃疡, 铁缺乏, 细胞免疫功能

Abstract: PURPOSE: To study the relationship between abnormal iron metabolism and cellular immune dysfunction and recurrent oral ulcer. METHODS: A cross-sectional analysis of serum iron, ferritin and cellular immune function in 100 patients with recurrent oral ulcer and 100 healthy cases as control were performed. Logistic regression analysis was conducted to evaluate the relationship between serum ferritin and cellular immunity and recurrent oral ulcer using SPSS 19.0 software package. RESULTS: Serum iron, ferritin, CD3+, CD4+ and CD4+/CD8+ concentration significantly decreased in Rou group compared with the control group (P<0.01). Multiple logistic regression analysis showed serum iron, ferritin and CD3+, CD4+ decrease were the independent risk factors for the onset of ROU, whereas CD4+/CD8+ were the protective factors in the pathogenesis of ROU(P<0.05). CONCLUSIONS: Iron deficiency and cellular immune function is closely related to the pathogenesis of ROU.

Key words: Recurrent oral ulcer, Iron deficiency, Cellular immune function

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