DEC1蛋白在口腔鳞癌中的表达及临床意义

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (2): 217-220.

DEC1蛋白在口腔鳞癌中的表达及临床意义

游镜民，苏彤，夏昆，林璐，刘琼，朱腾飞

湖南省常德市第一人民医院口腔科,湖南常德 415003

收稿日期:2015-08-27 修回日期:2015-11-12 出版日期:2016-03-25 发布日期:2016-05-06
作者简介:游镜民(1985-),男,硕士,住院医师,E-mail:youjingmin85@163.com 苏彤, E-mail:sutongs@163.com

Expression of differentiated embryo-chondrocyte expressed gene l in oral squamous cell carcinoma and its clinical significance

YOU Jing-min, SU Tong, XIA Kun, LIN Lu, LIU qiong, ZHU Teng-fei

Department of Stomatology, First People's Hospital of Changde. Changde 415003, Hunan Province, China

Received:2015-08-27 Revised:2015-11-12 Online:2016-03-25 Published:2016-05-06

摘要/Abstract

摘要： 目的:研究软骨分化表达基因1(differentiated embryo-chondrocyte expressed gene l,DEC1)在口腔鳞癌中的表达,以期为口腔鳞癌的诊断和预后评估提供依据。方法:采用免疫组织化学方法检测80例口腔鳞癌组织及30例正常口腔黏膜组织中DEC1蛋白的表达,并分析相关的临床病理因素。采用SPSS10.0软件包对数据进行统计学分析。结果:口腔鳞癌组织中DEC1的阳性表达率为92.50％,正常口腔黏膜组织中DEC1的阳性表达率为6.67％,两者差异显著(P＜0.05)。DEC1的表达在高、中、低不同分化程度口腔鳞癌组织之间以及在有、无淋巴结转移的口腔鳞癌组织之间的差异具有统计学意义(P＜0.05)。结论:DEC1的表达上调可能与口腔鳞癌的发生、发展有关。

关键词: DEC1, 口腔鳞癌, 免疫组织化学

Abstract: PURPOSE: To investigate the expression of differentiated embryo-chondrocyte expressed gene l(DEC1)in oral squamous cell carcinoma(OSCC)and its clinical significance. METHODS: Detection of the protein expression of DEC1 in tissue specimens from 80 primary OSCC patients and 30 cases of normal oral mucosa were performed using immunohistochemistry. SPSS10.0 software package was uses for statistical analysis. RESULTS: The result of immunohistochemistry showed that positive expression rate of DEC1 in OSCC tissues was 92.50%, 5.00% in normal oral mucosa tissue. The difference was statistically significant (P<0.05). In OSCC tissues, the difference in expression of DEC1 was statistically significant (P<0.05) between highly differentiated group and lowly differentiated group, between patients with lymph node metastasis and patients without lymph node metastasis. CONCLUSIONS: The significantly increased DEC1 gene may be associated with the tumorigenesis and development of OSCC.

Key words: Differentiated embryo-chondrocyte expressed gene l, Oral squamous cell carcinoma, Immunohistochemistry

中图分类号:

R739.8

游镜民，苏彤，夏昆，林璐，刘琼，朱腾飞. DEC1蛋白在口腔鳞癌中的表达及临床意义[J]. 上海口腔医学, 2016, 25(2): 217-220.

YOU Jing-min, SU Tong, XIA Kun, LIN Lu, LIU qiong, ZHU Teng-fei. Expression of differentiated embryo-chondrocyte expressed gene l in oral squamous cell carcinoma and its clinical significance[J]. Shanghai Journal of Stomatology, 2016, 25(2): 217-220.

参考文献

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