IL-35在牙周炎及口腔扁平苔藓中的表达及相关性分析

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (4): 443-447.

IL-35在牙周炎及口腔扁平苔藓中的表达及相关性分析

王玉, 靳赢, 王奕月, 胥丹妮, 林晓萍

中国医科大学附属盛京医院口腔科,辽宁沈阳 110004

收稿日期:2015-08-19 出版日期:2016-08-25 发布日期:2016-09-06
通讯作者: 林晓萍,E-mail: xiaoping_ba@126.com
作者简介:王玉（1992-）,女 ,硕士研究生,
基金资助:
高等学校博士学科点专项科研基金 (20112104110013); 辽宁省科学技术计划项目（2012225015）; 沈阳市科学技术计划项目（F13-221-9-28）

The expression and clinical significance of IL-35 in periodontitis and oral lichen planus

WANG Yu, JIN Ying, WANG Yi-yue, XU Dan-ni, LIN Xiao-ping

Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China

Received:2015-08-19 Online:2016-08-25 Published:2016-09-06

摘要/Abstract

摘要： 目的探讨IL-35在牙周炎及口腔扁平苔藓免疫机制中的作用及相关影响,以及牙周炎与口腔扁平苔藓之间的相互关系。方法按纳入标准选择单纯口腔扁平苔藓患者20例,单纯牙周炎患者20例,牙周炎伴口腔扁平苔藓患者20例和健康者12例;记录患者的一般信息及牙周探诊深度、临床附着丧失、牙龈指数、龈沟出血指数,并收集静脉血清及龈沟液样本,采用酶联免疫吸附测定血清及龈沟液中IL-35的表达水平。采用SPSS19.0软件包对数据进行统计学分析。结果单纯口腔扁平苔藓组、单纯牙周炎组、牙周炎伴口腔扁平苔藓组龈沟液及血清中IL-35浓度显著高于健康对照组（P<0.01）,牙周炎伴口腔扁平苔藓组龈沟液及血清中IL-35浓度显著高于单纯口腔扁平苔藓组及牙周炎组（P<0.05）;各组牙周临床指标与龈沟液及血清中IL-35表达水平呈正相关关系。结论牙周炎及口腔扁平苔藓中IL-35表达水平显著升高,其升高程度与两者呈正相关。

关键词: 白细胞介素35, 牙周炎, 口腔扁平苔藓, 血清龈沟液

Abstract: PURPOSE: To investigate the influence of IL-35 in the pathogenesis of periodontitis and oral lichen planus, and the correlation between periodontitis and oral lichen planus patients. METHODS: The gingival crevicular fluid（GCF） and serum were collected from patients with oral lichen planus (n=20), periodontitis (n=20), periodontitis and oral lichen planus (n=20) and healthy controls (n=12). The patients' basic information, probing depth, clinical attachment loss, gingival index, sulcus bleeding index were measured and collected. The expression of IL-35 in GCF and serum was detected by ELISA. SPSS19.0 software package was used for statistical analysis. RESULTS: The concentration of IL-35 in patients with periodontitis and oral lichen planus was significantly higher than that of other groups(P<0.05). There was significantly positive correlation between IL-35 level and periodontal clinical parameters. CONCLUSIONS: Periodontitis and oral lichen planus may increase the concentration of IL-35 both in serum and GCF. The expression of IL-35 was positively correlated with periodontitis and oral lichen planus.

Key words: IL-35, Periodontitis, Oral lichen planus, Serum, Gingival crevicular fluid

中图分类号:

R781.4

王玉, 靳赢, 王奕月, 胥丹妮, 林晓萍. IL-35在牙周炎及口腔扁平苔藓中的表达及相关性分析[J]. 上海口腔医学, 2016, 25(4): 443-447.

WANG Yu, JIN Ying, WANG Yi-yue, XU Dan-ni, LIN Xiao-ping. The expression and clinical significance of IL-35 in periodontitis and oral lichen planus[J]. Shanghai Journal of Stomatology, 2016, 25(4): 443-447.

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