亚砷酸致颌骨坏死的诊治:附10例报道

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (6): 755-758.

亚砷酸致颌骨坏死的诊治:附10例报道

吴烨, 林李嵩, 牛刚, 谢福平

福建医科大学附属口腔医院口腔颌面外科,福建福州 350002

收稿日期:2014-08-06 修回日期:2014-09-29 出版日期:2014-12-20 发布日期:2015-01-08
通讯作者: 林李嵩,Tel:0591-83736425,E-mail:dr_lls@163.com E-mail:1713746079@qq.com
作者简介:吴烨（1975-）,男,硕士,副主任医师
基金资助:
2009年中华人民共和国人力资源和社会保障部; 留学人员科技活动项目择优资助; 福建省自然科学基金(2014J01316）; 福建省教育厅基金（JA11125）

The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases

WU Ye, LIN Li-song, NIU Gang, XIE Fu-ping

Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Fujian Medical University. Fuzhou 350002, Fujian Province, China

Received:2014-08-06 Revised:2014-09-29 Online:2014-12-20 Published:2015-01-08
Supported by:
Preferential Funding Overseas Personnel Activities in Science and Technology Project of Ministry of Human Resources and Social Security of China (2009), Natural Science Foundation of Fujian Province(2014J01316) and Foundation of Department of Education of Fujian Province（JA11125）

摘要/Abstract

摘要： 目的：探讨亚砷酸外漏所致颌骨坏死的诊断与治疗,强调其使用的严重后果。方法：收集我科2009年1月—2014年6月收治的10例亚砷酸致颌骨坏死患者,分析总结其诊断与治疗要点。结果：结合病史、临床检查、X线检查及与原发性颌骨内癌等鉴别得出诊断;术前或术中行锥形束CT（CBCT）等检查,9例患者通过一期手术治愈,1例患者通过二次广泛手术治愈。结论：因亚砷酸的毒性大,无自限性,临床上应避免使用。

关键词: 亚砷酸, 颌骨坏死, 医源性损伤

Abstract: PURPOSE: To discuss the diagnosis and treatment of necrosis of jaws caused by leakage of arsenite trioxide, and to emphasize the consequences of its use. METHODS: Ten cases of arsenical necrosis of the jaws from Jan, 2009 to Jun, 2014 treated in our department were collected and analyzed, with emphasis on the key points of diagnosis and treatment. RESULTS: Diagnosis was based on medical history, clinical examinations, X-ray findings, and preoperative or intraoperative cone-beam CT (CBCT) scans. Nine patients were cured with primary operation, one patient was cured by secondary extended surgery. CONCLUSIONS: Because of the high toxicity, there is no justification for the use of arsenite trioxide in clinic.

Key words: Arsenic trioxide, Necrosis of jaws, Iatrogenic injury

中图分类号:

R782.4

吴烨, 林李嵩, 牛刚, 谢福平. 亚砷酸致颌骨坏死的诊治:附10例报道[J]. 上海口腔医学, 2014, 23(6): 755-758.

WU Ye, LIN Li-song, NIU Gang, XIE Fu-ping. The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases[J]. Shanghai Journal of Stomatology, 2014, 23(6): 755-758.

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