口腔颌面部淋巴结生发中心进行性转化：附3例报告

上海口腔医学 ›› 2013, Vol. 22 ›› Issue (5): 551-554.

口腔颌面部淋巴结生发中心进行性转化：附3例报告

黄林江，宣桂红，李敏

(绍兴市人民医院口腔科，浙江绍兴 312000)

收稿日期:2013-05-06 修回日期:2013-08-28 出版日期:2013-10-10 发布日期:2013-10-10
通讯作者: 黄林江，E-mail：zjsxhlj@163.com
作者简介:黄林江(1964-)，男，硕士，主任医师
基金资助:
绍兴市科技计划资助项目(2011A23029)

Progressively transformed germinal center in oral and maxillofacial region: report of 3 cases

HUANG Lin-jiang, XUAN Gui-hong, LI Min

Department of Stomatology, Shaoxing People’s Hospital. Shaoxing 312000, Zhejiang Province, China

Received:2013-05-06 Revised:2013-08-28 Online:2013-10-10 Published:2013-10-10
Supported by:
Supported by Science and Technology Plan Project of Shaoxing City(2011A23029).

摘要/Abstract

摘要： 目的：探讨淋巴结生发中心进行性转化(progressively transformed germinal center，PTGC) 的诊断、预后，提出持续随诊和重复淋巴结活检的必要性，以指导临床治疗。方法：收集2010—2012年收治的3例病理确诊的PTGC病例，结合文献，分析其临床特点、组织病理学特征、鉴别诊断及预后。结果：3例均为青壮年男性，腮腺区2例，颈部1例，均行手术切除，随访8个月~2.5 a，均无复发。结论：PTGC多见于青壮年男性，多位于颈部，表现为孤立、无痛性淋巴结肿大，多数曾以淋巴结炎进行过治疗但疗效不佳。确诊主要依靠组织病理学检查，注意与结节性淋巴细胞为主型霍奇金淋巴瘤的关系。

关键词: 淋巴结生发中心进行性转化, 反应性淋巴滤泡增生, 结节性淋巴细胞为主型霍奇金淋巴瘤, 滤泡型淋巴瘤

Abstract: PURPOSE: To discuss the diagnosis and prognosis of progressively transformed germinal center and emphasize the necessity of long term follow-up after treatment. METHODS: Three patients were diagnosed as progressively transformed germinal center (PTGC) from 2010 to 2012. The clinical characteristics, histological features, differential diagnosis, prognosis were analyzed with review of literatures. RESULTS: Among 3 cases, 2 were found around parotid gland, one was in the neck. All patients were young male adults, who received excisional biopsy and regular histopathological examination. They were followed up for 8 months to 2.5 years, no relapse was found. CONCLUSIONS: PTGC occurs more commonly in young male adults. It always appears as an isolated and painless enlarged lymph node, which responses poorly to antibiotics. The final diagnosis is relied on histopathological and immunocytochemical examinations. Close follow-up is necessary, and attention should be paid to nodular lymphocyte predominant Hodgkin’s disease although there is no clear evidence about their relationship of development.

Key words: Progressively transformed germinal center, Reactive follicular hyperplasia, Nodular lymphocyte predominant Hodgkin’s disease, Follicular lymphoma

中图分类号:

R551.2

黄林江, 宣桂红, 李敏. 口腔颌面部淋巴结生发中心进行性转化：附3例报告[J]. 上海口腔医学, 2013, 22(5): 551-554.

HUANG Lin-jiang, XUAN Gui-hong, LI Min. Progressively transformed germinal center in oral and maxillofacial region: report of 3 cases[J]. Shanghai Journal of Stomatology, 2013, 22(5): 551-554.

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