上海口腔医学

上海口腔医学 ›› 2023, Vol. 32 ›› Issue (1): 80-84.doi: 10.19439/j.sjos.2023.01.015

• 论著 • 上一篇    下一篇

CD44与CD33在77例口腔黏膜良性淋巴组织增生病中的表达及临床意义

王训霞, 姜国萍, 张勇哲, 李爱群, 王瑞春   

  1. 青岛市中医医院 口腔科,山东 青岛 266000
  • 收稿日期:2022-01-25 修回日期:2022-05-23 出版日期:2023-02-25 发布日期:2023-06-12
  • 通讯作者: 王瑞春,E-mail:wangrc20220101@163.com
  • 作者简介:王训霞（1981-）,女,硕士研究生,副主任医师, E-mail:wangxunxia@163.com
  • 基金资助:
    山东省自然科学基金 (2019225)

Expression level and clinical significance of CD44 and CD33 in 77 patients with benign lymphoadenosis of oral mucosa

WANG Xun-xia, JIANG Guo-ping, ZHANG Yong-zhe, LI Ai-qun, WANG Rui-chun   

  1. Department of Stomatology, Qingdao Traditional Chinese Medicine Hospital. Qingdao 266000, Shandong Province, China
  • Received:2022-01-25 Revised:2022-05-23 Online:2023-02-25 Published:2023-06-12

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摘要： 目的: 探讨CD44与CD33在口腔黏膜良性淋巴组织增生病（benign lymphoadenosis of oral mucosa,BLOM）中的表达及临床意义。方法: 选择2017年1月—2020年3月青岛市中医医院病理科77例BLOM蜡块作为实验组,另取同时间段63例正常口腔黏膜组织蜡块作为对照组。采用免疫组织化学法检测2组CD44、CD33阳性表达情况,采用Spearman分析BLOM患者病变组织中CD33与CD44阳性表达的相关性。收集患者一般资料,分析BLOM患者病变组织中CD33、CD44表达与临床病理特征的关系。采用SPSS 21.0软件包对数据进行统计学分析。结果: 对照组、实验组CD33阳性表达率分别为95.24%、63.64%,差异有统计学意义（P<0.05）;CD44阳性表达率分别为93.65%、67.53%,差异有统计学意义（P<0.05）。Spearman分析结果显示,BLOM患者病变组织中CD33与CD44阳性表达呈正相关（r=0.834,P=0.002）;CD33、CD44表达与临床分型、炎症程度、有无淋巴滤泡、淋巴细胞浸润有关（P<0.05）,而与年龄、性别、病程、病变部位、上皮表面角化无关（P>0.05）。结论: BLOM患者病变组织中CD33、CD44阳性表达率下降,与临床分型、炎症程度、有无淋巴滤泡、淋巴细胞浸润密切相关。

关键词: CD44, CD33, 口腔黏膜良性淋巴组织增生病

Abstract: PURPOSE: To investigate the expression and clinical significance of CD44 and CD33 in benign lymphoadenosis of oral mucosa(BLOM). METHODS: From January 2017 to March 2020, seventy-seven BLOM wax blocks from the Department of Pathology of Qingdao Traditional Chinese Medicine Hospital were selected as the experimental group, and 63 cases of normal oral mucosal tissue wax blocks during the same period were selected as the control group. Immunohistochemical method was used to detect the positive expression of CD44 and CD33 in the two groups.Spearman correlation analysis was used to analyze the correlation between the positive expression of CD33 and the positive expression of CD44 in the diseased tissues of BLOM patients.The general information about patients were collected.The relationship between the expression of CD33 and CD44 in the diseased tissues of BLOM patients and the clinicopathological characteristics of BLOM patients were analyzed. SPSS 21.0 software package was used for statistical analysis of the data. RESULTS: The positive expression rates of CD33 in the control group and the experimental group were 95.24% and 63.64%, respectively, and the difference was statistically significant(P<0.05). The positive expression rates of CD44 in the control group and the experimental group were 93.65% and 67.53%, respectively, and the difference was statistically significant(P<0.05). The results of Spearman correlation analysis showed that the positive expression of CD33 in the diseased tissues of BLOM patients was positively correlated with the positive expression of CD44 (r=0.834, P=0.002). The expression of CD33 and CD44 in the diseased tissues of patients with BLOM were related to clinical type, degree of inflammation, presence or absence of lymphoid follicles, and lymphocyte infiltration(P<0.05), but not related to age, gender, course of disease, location, and epithelial surface keratinization(P>0.05). CONCLUSIONS: The positive expression rate of CD33 and CD44 in the BLOM tissues decreased, which was closely related to the clinical type, degree of inflammation, presence or absence of lymphoid follicles, and lymphocyte infiltration.

Key words: CD44, CD33, Benign lymphoadenosis of oral mucosa

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