上海口腔医学

上海口腔医学 ›› 2019, Vol. 28 ›› Issue (3): 312-316.doi: 10.19439/j.sjos.2019.03.018

• 论著 • 上一篇    下一篇

加味逍遥丸治疗口腔扁平苔藓伴焦虑抑郁状态患者的疗效评价

刘伟东1,2, 赵民1   

  1. 1.山东省立医院 口腔科,山东 济南 250000;
    2.淄博市第一医院 口腔科,山东淄博 255200
  • 收稿日期:2018-11-16 修回日期:2019-03-16 出版日期:2019-06-25 发布日期:2019-08-09
  • 通讯作者: 赵民,E-mail:sdkqnmb@163.com
  • 作者简介:刘伟东（1989-）,男,硕士,住院医师,E-mail：363687267@qq.com

Clinical evaluation of modified Xiaoyao pill on the treatment of oral lichen planus patients with anxiety or depression

LIU Wei-dong1,2, ZHAO Min1   

  1. 1.Department of Stomatology, Shandong Provincial Hospital. Jinan 250000;
    2. Department of Stomatology, First Hospital of Zibo City. Zibo 255200, Shandong Province, China
  • Received:2018-11-16 Revised:2019-03-16 Online:2019-06-25 Published:2019-08-09

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摘要： 目的 探讨加味逍遥丸治疗口腔扁平苔藓（oral lichen planus,OLP)伴焦虑抑郁状态患者的临床疗效。方法 选取60例OLP伴焦虑抑郁状态的患者,随机分为实验组和对照组,每组30例。实验组口服加味逍遥丸、硫酸羟氯喹、Gum漱口液局部漱口;对照组口服硫酸羟氯喹和Gum漱口液局部漱口,疗程为4周。采用REU和VAS评分系统分别于初诊、第2周、第4周、第8周进行疗效评价,采用SPSS18.0软件包对数据进行统计学分析。结果 在观察期内,2组REU、VAS均低于治疗前（P<0.05）,2组总有效率无显著差异（P>0.05)。但实验组治疗糜烂型扁平苔藓（EOLP）的疗效更加显著,能加速糜烂型扁平苔藓愈合,降低患者的疼痛指数以及维持疗效,防止复发。REU、VAS评分与对照组相比有显著差异（P<0.05）。结论 加味逍遥丸治疗OLP伴焦虑抑郁状态的患者安全有效,尤其对于EOLP患者疗效显著。

关键词: 口腔扁平苔藓, 肝郁症, 加味逍遥丸, 焦虑自评量表, 抑郁自评量表

Abstract: PURPOSE: To investigate the clinical effect and safety of modified Xiaoyao pill on the treatment of oral lichen planus (OLP) patients with anxiety or depression. Methods: Sixty OLP patients with anxiety and depression were randomly divided into 2 groups, treated separately with hydroxychloroquine(HCQ, control group) and HCQ+modified Xiaoyao pill(experimental group). The results were measured with semi quantitative reticular erosive and ulcerative lesion (REU) and visual analogue scale（VAS） scoring system at the first visit, the second week, the fourth week and the eighth week, respectively. Data analysis was performed using SPSS 18.0 software package. Results: The clinical effect of HCQ+modified Xiaoyao pill was better than that of the HCQ. The REU, VAS scores were lower after treatment in both groups (P<0.05), but the effect of the experimental group was more remarkable in reducing the pain indexes, accelerating the healing of erosive lesion and preventing recurrence than the control group. There was no significant difference in the overall effective rate between the two groups (P>0.05). Conclusions: Modified Xiaoyao pill was effective and safe in the treatment of OLP patients with anxiety or depression, especially for EOLP.

Key words: Oral lichen planus, Liver-qi syndrome, Modified Xiaoyao pill, Self-rating anxiety scale, Self-rating depression scale

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