局部应用多西环素对脱位恒牙愈合效果的影响

doi:10.19439/j.sjos.2019.06.017

上海口腔医学 ›› 2019, Vol. 28 ›› Issue (6): 640-643.doi: 10.19439/j.sjos.2019.06.017

局部应用多西环素对脱位恒牙愈合效果的影响

刘义, 朱晸, 孙楚文, 赵隽隽^*, 朱铭颐^*

上海交通大学医学院附属第九人民医院·口腔医学院口腔综合科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2018-06-04 出版日期:2019-12-25 发布日期:2020-01-14
通讯作者: 朱铭颐,E-mail：zhumingyi9h@163.com;赵隽隽,E-mail：zhaojj1381@2m9h.net。^*共同通信作者
作者简介:刘义（1983-）,男,硕士,住院医师,E-mail：liuyi_119@hotmail.com

Effects of topical application of doxycycline on avulsed permanent teeth

LIU Yi, ZHU Zheng, SUN Chu-wen, ZHAO Jun-jun, ZHU Ming-yi

Department of General Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China;

Received:2018-06-04 Online:2019-12-25 Published:2020-01-14

摘要/Abstract

摘要： 目的评价使用多西环素和生理盐水处理脱位恒牙对牙髓及牙周愈合的影响。方法将38例患者（男22例,女16例,年龄7~14岁）的44颗脱位恒牙随机分为2组。在复位植入牙槽窝前,A组21颗牙使用0.05 mg/mL多西环素溶液浸泡5 min,B组23颗牙使用生理盐水浸泡5 min。术后定期随访并观察牙根发育情况, 使用Mann-Whitney U检验评价2组愈合情况的差异。结果 2组脱位牙之间的基本特征无显著差异。A组18颗牙被诊断为牙髓坏死,3颗牙有炎症性吸收,13颗牙有骨性黏连,6颗被拔除。B组16颗牙被诊断为牙髓坏死,4颗牙有炎症性吸收,12颗牙有骨性黏连,7颗被拔除。2组间的主要临床随访结局差异无统计学意义。结论与生理盐水相比,使用多西环素溶液处理脱位恒牙并未显示出明显的优势。

关键词: 牙脱位, 年轻恒牙, 多西环素

Abstract: PURPOSE: To evaluate the treatment effect of topical doxycycline on avulsed permanent teeth compared with normal saline. METHODS: A total of 44 avulsed teeth from 38 patients (22 boys and 16 girls, aged 7-14 years) were recruited. Twenty-one teeth in group A were treated with doxycycline for 5 min before replantation while 23 teeth in group B were treated with saline solution. All participants were followed up for at least 12 months. The clinical outcome differences between 2 groups was evaluated by Mann-Whitney U test. RESULTS: In group A, 18 teeth were found pulp necrosis, 3 with infection-related resorption, 13 with ankylosis-related resorption and 6 were extracted. In group B, 16 were diagnosed with pulp necrosis, 4 with infection-related resorption, 12 with ankylosis-related resorption and 7 were extracted. No significant differences were found between the two groups on pulp survival and periodontal healing. CONCLUSIONS: Compared with treatment with normal saline, avulsed permanent teeth treated with doxycycline did not show a better clinical outcome.

Key words: Tooth avulsion, Immature permanent teeth, Doxycycline

中图分类号:

R782.1

刘义, 朱晸, 孙楚文, 赵隽隽, 朱铭颐. 局部应用多西环素对脱位恒牙愈合效果的影响[J]. 上海口腔医学, 2019, 28(6): 640-643.

LIU Yi, ZHU Zheng, SUN Chu-wen, ZHAO Jun-jun, ZHU Ming-yi. Effects of topical application of doxycycline on avulsed permanent teeth[J]. Shanghai Journal of Stomatology, 2019, 28(6): 640-643.

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局部应用多西环素对脱位恒牙愈合效果的影响

Effects of topical application of doxycycline on avulsed permanent teeth

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