Role of Bcl-2 and MIF proteins in senile patients with gingival cancer

doi:10.19439/j.sjos.2019.01.022

Abstract

Abstract: PURPOSE: To investigate the expression of Bcl-2 protein and macrophage migration inhibitory factor (MIF) protein in gingival carcinoma of the elderly and its clinical significance. METHODS: Sixty-two gingival cancer tissue specimens in the elderly diagnosed in our hospital from January 2015 to September 2017 were selected as the experimental group, and 31 normal gingival tissues were selected as the control group. Immunohistochemical staining was used to detect the expression of Bcl-2 protein and MIF protein in two groups. The differences of Bcl-2 protein and MIF protein in different clinical stages, cervical lymph node metastasis and histological differentiation were analyzed. The data were analyzed with SPSS 16.0 software package for Chi-square test. RESULTS: The positive expression rates of Bcl-2 protein and MIF protein in the gingival cancer samples of the experimental group were 67.74% and 70.97%, respectively. The positive expression rates of Bcl-2 protein and MIF protein in the gingival tissues of the control group were 16.13% and 22.58%, respectively. The difference was statistically significant (P<; 0.05). The positive expression rate of Bcl-2 protein in gingival carcinoma tissues with different degrees of differentiation was statistically significant (P<; 0.05). In different degrees of differentiation, gingival carcinoma with cervical lymph node metastasis, there was significant difference in the positive expression rate of MIF protein in gingival cancer tissues (P<; 0.05). CONCLUSIONS: The expression of Bcl-2 and MIF protein is up-regulated in gingival cancer tissues of the elderly, which has certain relationship with the degree of tumor differentiation and cervical lymph node metastasis.

Key words: Geriatric, Gingival cancer, Bcl-2 protein, Macrophage migration inhibitory factor

CLC Number:

R739.8

FANG Shou-rong. Role of Bcl-2 and MIF proteins in senile patients with gingival cancer[J]. Shanghai Journal of Stomatology, 2020, 29(1): 105-108.

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