Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation

doi:10.19439/j.sjos.2019.05.009

Abstract

Abstract: PURPOSE: To study the effect of dimethylamine tetracycline combined with tea polyphenols on the levels of interleukin-1 β (IL-1β) and interleukin-17F (IL-17F) in patients with early peri-implant soft tissue inflammation. METHODS: Ninety-six patients with early peri-implant soft tissue inflammation were selected from May 2016 to May 2018. They were randomly divided into dimethylamine tetracycline group and combination group, 48 cases in each group. Patients in the dimethylamine tetracycline group were treated with dimethylamine tetracycline hydrochloride ointment, while patients in the combined group were treated with tea polyphenols on the basis of dimethylamine tetracycline group. Plaque index (PLI), sulcus bleeding index (SBI), attachment loss (AL), gingival crevicular fluid (GCF), probing depth (PD), IL-1β and IL-17F levels were detected. The data were analyzed using SPSS 20.0 software package. RESULTS: After treatment, PLI, SBI, AL, GCF and PD in both groups were significantly lower than those before treatment (P<0.05). The levels of PLI, SBI, AL, GCF and PD in the combined group were significantly lower than those in the dimethylamine tetracycline group after treatment (P<0.05). After treatment, the levels of IL-1beta and IL-17F in both groups were significantly lower than those before treatment (P<0.05). After treatment, the levels of IL-1β and IL-17F in the combined group were significantly lower than those in the dimethylamine tetracycline group (P<0.05). The effective rate of combined group was 93.75%, which was significantly higher than that of dimethylamine tetracycline group (77.08%, P<0.05). The adverse reaction rate of the combined group was 6.25% ,significantly lower than that of the dimethylamine tetracycline group (20.83%, P<0.05). CONCLUSIONS: Dimethylamine tetracycline combined with tea polyphenols in the treatment of early peri-implant soft tissue inflammation has significant effect. It can improve the clinical symptoms of patients, reduce the levels of IL-1β and IL-17F, and decrease the occurrence of adverse effects.

Key words: Dimethylamine tetracycline, Tea polyphenols, Periimplantitis, Interleukin-1β, Interleukin-17F

CLC Number:

R781.4

LI Yu-leng, WANG Wei-zhong, GONG Zhong-cheng. Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation[J]. Shanghai Journal of Stomatology, 2019, 28(5): 494-498.

References

[1] 伍志荣. 种植体周围炎的病因、临床检查与治疗进展[J].口腔疾病防治,2018,26(6):401-405.
[2] 马翔, 柳忠豪. 3557例种植患者种植体周围炎的回顾性研究[J]. 实用口腔医学杂志, 2018, 34(5): 665-669.
[3] Luo Z, Wang H, Chen J, et al.Overexpression and potential regulatory role of IL-17F in pathogenesis of chronic periodontitis[J]. Inflammation, 2015, 38(3): 978-986.
[4] 胡加凤, 俞海娜. 复方茶多酚漱口液对小儿慢性牙周炎患儿的影响及其机制[J].中国生化药物杂志, 2016, 36(2): 133-135.
[5] Basu A, Masek E, Ebersole JL.Dietary polyphenols and periodontitis-a mini-review of literature[J]. Molecules, 2018, 23(7): E1786.
[6] Chava VK, Vedula BD.Thermo-reversible green tea catechin gel for local application in chronic periodontitis: a 4-week clinical trial[J]. J Periodontol, 2013 , 84(9): 1290-1296.
[7] 赖红昌. 种植体周围炎与牙周炎的类比探究[J].口腔医学, 2018, 38(12):1057-1061.
[8] 释栋. 种植体周围炎再生治疗5年观察1例[J]. 中华口腔医学杂志, 2018,53(4): 271-274.
[9] 赖海燕, 王伟, 顾新华. 种植体表面打磨抛光处理在种植体周围炎治疗中的应用[J]. 中华口腔医学杂志, 2018, 53(12): 854-857.
[10] Ramasamy C.Potential natural antioxidants: adjuvant effect of green tea polyphenols in periodontal infections[J]. Infect Disord Drug Targets, 2015, 5(3): 141-152.
[11] Ben Lagha A, Haas B, Grenier D.Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum[J]. Sci Rep, 2017, 7: 44815.
[12] 陈一, 谢永林, 杜胜男. 茶多酚联合米诺环素治疗早期种植体周围软组织炎的效果及对DPD、MCP-1水平的影响[J].川北医学院学报,2019,34(1): 68-70.
[13] 金权, 许立硕, 黄玉, 等. 穿心莲内脂联合黄芩素治疗种植体周围炎的临床疗效观察[J]. 全科口腔医学电子杂志, 2018, 5(30): 36-37.
[14] 孙泽华, 李琳琳, 李美华. 种植体周围炎发生因素分析[J].中国实验诊断学, 2017, 21(7): 1274-1276.
[15] Bostanci V, Toker H, Senel S, et al.Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever[J]. Clin Oral Investig, 2017, 21(1): 469-475.
[16] Mesa F, Lanza E, García L, et al.Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent[J]. PLoS One, 2017, 12(10): e0186366.
[17] 邵艳琳, 刘玲, 陈一, 等. 白细胞介素1与种植体周围病相关性的meta分析[J].临床口腔医学杂志, 2019, 35(3): 153-158.
[18] 孙辉. 种植体周围炎龈沟液中白细胞介素17F和干扰素γ的表达及临床意义[J]. 牙体牙髓牙周病学杂志, 2018, 28(8): 461-465.
[19] 夏长普, 冯金兰, 吴峥嵘, 等. 茶多酚漱口液对牙周炎患者脂联素及炎症因子的影响[J].广东医学, 2016, 37(4): 613-615.