Effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer and on immune regulation

doi:10.19439/j.sjos.2018.05.017

Abstract

Abstract: PURPOSE: To study the effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer (ROU) and on immunological regulation. METHODS: This randomized controlled clinical study prospectively enrolled 204 patients with ROU who were randomly divided into 2 groups. Patients in group A received Garlicin Capsules 1/time, 3 times/d, combined with Kangfuxin liquid 10 mL to gargle 3 times/d; patients in group B only received Kangfuxin liquid 10 mL gargle 5 min, 3/d. The treatment lasted for 2 weeks. The curative effect was compared before and after treatment, including ulcer surface pain (VAS score), time of ulcer healing, and the changes of T cell subsets (CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺) before and after treatment were compared by SPSS 22 software package. RESULTS: Ulcer healing time (3.5±0.6) d, duration of pain (3.1±0.3)d in group A were shorter than in group B (P<0.05); treatment efficiency was 96.08% in group A, 88.24% in group B( χ²=6.264, P<0.05). The pain scores of both groups were significantly reduced after treatment, and the difference was significant between group A and group B [(1.1±0.4) vs (3.2± 0.6)(P<0.05). The levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in group A were significantly higher than those in group A after treatment (P<0.05), the levels of CD8⁺ was significant lower than in group B (P<0.05). CONSLUSIONS: Kangfuxin liquid combined with Garlicin Capsules can improve the therapeutic effect of ROU and repair of local damaged mucosa in children, increasing the immune function of children.

Key words: Rehabilitation liquid, Garlicin Capsules, Recurrent oral ulcer, Immune regulation

CLC Number:

R781.5

MA Peng-tao, WU Ning-ning, PEI Rong. Effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer and on immune regulation[J]. Shanghai Journal of Stomatology, 2018, 27(5): 526-529.

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