Effects of MMPs inhibitors on microleakage with wet bonding technique

Abstract

Abstract: PURPOSE: To observe the effects of matrix metalloproteinasesMMPs inhibitors on microleakage with wet bonding technique. METHODS: Twenty-seven premolars were randomly assigned to 3 groups. Class Ⅴ cavities were prepared in the neck of the teeth and treated with distilled water, 2% chlorhexidine CHX or 2% monocycline MI for 60 seconds. Resin was used to restore the prepared cavities following application of luting agent. Samples in each group were soaked for 1 h with 10% NaClO and then 2 layers of nail polish were applied, followed by treatment with 50wt% ammoniated silver nitrate ASN, and developing solution in turn. Each tooth was sectioned longitudinally to 1~2 mm slices and examined with stereo microscope and scanning electron microscope SEM. The data were analyzed with SPSS 16.0 software package for Wilcoxon rank sum test. RESULTS: There was varied microleakage at the margin. The difference was significant between group CHX and control group, between group MI and control group; However, there was no significant difference between group CHX and group MI. CONCLUSIONS: MMPs inhibitor can reduce microleakage with wet bonding technique.

Key words: Dentin bonding, Matrix metalloproteinases inhibitor, Chlorhexidine, Monocycline, Microleakage

CLC Number:

R783.1

ZHAO Cong, CHI Shuang, LI Tong, LI He, LI Tian-bo, ZHANG Zhi-min. Effects of MMPs inhibitors on microleakage with wet bonding technique[J]. Shanghai Journal of Stomatology, 2016, 25(5): 548-552.

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