Detection of gingipain K in the gingival crevicular fluid of orthodontic patients

Abstract

Abstract: PURPOSE: To explore the correlation between gingipain K (Kgp) and inflammatory reaction of gum in the process of orthodontic treatment, and analyse the role of Kgp in the development of gingivitis during orthodontic treatment. METHODS: Totally 45 orthodontic healthy teenagers were randomly chosen for the study. The subgingival plaques were collected simultaneously before orthodontic treatment and 3 months after treatment. 16S rDNA PCR technique was used to detect Porphyromonas gingivalis (P.g) and Kgp. SPSS17.0 software package was used for statistical analysis. RESULTS: The detection rate of Kgp was 35.71% before orthodontic treatment and 67.86% after treatment. Positive correlation (P<0.05) was observed between Kgp and gingival inflammation. CONCLUSIONS: Fixed orthodontic appliances cause plaque accumulation, accordingly slight gingiva inflammation and the increament of P.gingivalis in the early stage.

Key words: Orthodontic treatment, Gingipain K, 16S rDNA PCR technique, Gingivitis

CLC Number:

R783.5

YANG Gang-ling,LI Wei-zhe,HAN Zhi-qiang,XIAO Shui-qing. Detection of gingipain K in the gingival crevicular fluid of orthodontic patients[J]. Shanghai Journal of Stomatology, 2015, 24(1): 102-106.

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