Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats

doi:10.19439/j.sjos.2023.03.004

Shanghai Journal of Stomatology ›› 2023, Vol. 32 ›› Issue (3): 241-245.doi: 10.19439/j.sjos.2023.03.004

• Original Articles • Previous Articles Next Articles

Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats

LI Jun-fu¹, ZHU Jia², JIANG Juan¹, WANG Xu-xia³, CHEN Dai-yun⁴, ZHAO Zuo-qin⁴

1. Department of Stomatology, Second Affiliated Hospital of Shandong First Medical University. Tai'an 271000, Shandong Province;
2. Department of Stomatology, South Taihu Hospital. Huzhou 313000, Zhejiang Province;
3. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University; Shandong Key Laboratory of Oral Tissue Regeneration; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong University. Jinan 250012, Shandong Province;
4. School of Stomatology, Shandong First Medical University. Tai'an 271000, Shandong Province, China

Received:2021-11-25 Revised:2022-05-20 Online:2023-06-25 Published:2023-06-28

Abstract

Abstract: PURPOSE: To investigate the effect of collagen sponge on early bone healing process of alveolar fossa after tooth extraction in rats. METHODS: A total of 16 healthy female SD rats were selected. Animal models with tooth extraction were established. The right alveolar fossa inserted with collagen sponge was as the experimental group, and the left alveolar fossa was as the control group with treatment. The rats were sacrificed 1, 2, 4 and 8 weeks after tooth extraction, and the osteogenesis of alveolar fossa was observed. Real-time quantitative PCR (qt-PCR) was used to detect the changes of osteogenesis related gene expression. SPSS 19.0 software package was used for statistical analysis. RESULTS: After surgery, alveolar cavity healing was significantly better in the experimental group than in the control group. Osterix, Runx2 and Vegf genes were expressed in the experimental group and the control group, and the expression levels of related genes in the experimental group were significantly higher than the control group 1, 2, 4 and 8 weeks after surgery(P<0.05). CONCLUSIONS: Collagen sponge could promote early alveolar bone healing, possibly related to the expression level of osteogenic genes regulated by collagen sponge.

Key words: Collagen sponge, Alveolar fossa, Gene expression, Real-time quantitative PCR

CLC Number:

R782.1

LI Jun-fu, ZHU Jia, JIANG Juan, WANG Xu-xia, CHEN Dai-yun, ZHAO Zuo-qin. Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats[J]. Shanghai Journal of Stomatology, 2023, 32(3): 241-245.

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Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats

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