Effect of early enteral nutritional support on 44 patients with postoperative chemoradiotherapy for oral and oropharyngeal cancers

doi:10.19439/j.sjos.2021.06.017

Abstract

Abstract: PURPOSE: To investigate the effects of enteral nutritional support on nutritional status and quality of life of patients with postoperative chemoradiotherapy for oral and oropharyngeal cancer 2 weeks before radiotherapy. METHODS: This study retrospectively analyzed the nutritional status and life quality of 44 patients with oral and oropharyngeal cancer, who were nutritionally intervened at different times with postoperative chemoradiotherapy. Based on the weight 2 weeks prior to radiotherapy as a covariate to correct the baseline, weight, body mass index, as well as their changes from baseline, and patients' generated-subjective global assessment, global health status, physical function and fatigue in the quality of life questionnaire (EORTC QLQ-C30 & H&N35) were evaluated. SPSS 19.0 software package was used for repeated measurement analysis of variance. RESULTS: The total number of early intervention (2 weeks before radiotherapy to 2 weeks after the end of radiotherapy) was 25 and reactive intervention(3 weeks after radiotherapy to 2 weeks after the end of radiotherapy) was 19. The weight of both groups showed a downward trend during the chemoradiotherapy period, but the degree in the early intervention group was significantly smaller (P=0.023). PG-SGA of both groups showed significant decrease during the follow-up period, especially that in the early intervention group(P=0.027). The global health status of two groups was overall improved, but patients in both groups experienced fatigue, and their physical function continued fading, especially those in reactive intervention group(P>0.05). There was no significant difference in the grades of oral mucositis between two groups. CONCLUSIONS: The nutritional status of patients with oral and oropharyngeal cancer undergoing postoperative chemoradiotherapy decreased significantly. Early enteral nutritional support can sustain weight and improve patients' nutritional status to some extent, but fails to enhance the quality of life of patients.

Key words: Early enteral nutrition, Oral and oropharyngeal cancer, Postoperative chemoradiotherapy, Nutritional status, Quality of life

CLC Number:

R739.8

HAN Qiu-ye, DOU Sheng-jin, JIANG Wen, LI Rong-rong, ZHANG Hai-feng, ZHU Guo- pei. Effect of early enteral nutritional support on 44 patients with postoperative chemoradiotherapy for oral and oropharyngeal cancers[J]. Shanghai Journal of Stomatology, 2021, 30(6): 649-653.

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