Evaluation of the application of dexmedetomidine combined with flurbiprofen axetil in extraction of multiple complex teeth under local anesthesia

doi:10.19439/j.sjos.2021.03.016

Abstract

Abstract: PURPOSE: To evaluate the safety and efficacy of sedation and analgesia using dexmedetomidine combined with flurbiprofen axetil in multiple complex teeth extraction under local anesthesia. METHODS: According to the inclusion and exclusion criteria of the study, 40 patients scheduled for multiple complex teeth (4-6) extraction were randomly divided into 2 groups: experimental group (sedation and analgesia using dexmedetomidine combined with flurbiprofen axetil in addition to local anesthesia, n=20) and control group (local anesthesia, n=20). The mean arterial pressure(MAP), heart rate(HR), Ramsay sedation score, VAS pain score of each patient at T0(basis value), T1 (during local anesthesia), T2(during extraction), T3(10 minutes after extraction) and the follow-up results were recorded. SAS 8.0 software was used for statistical analysis. RESULTS: Compared to T0 and control group at the same time, the experimental group revealed more stable mood and hemodynamic manifestation and better analgesic effect (P<0.05), from T1 to T3, patients in the control group showed increased blood pressure, heart rate, emotional fluctuation, bodily and facial pain(P<0.05). The follow-up results showed 5 and 0 patients taking painkillers in the control and experimental group, respectively(P<0.05). CONCLUSIONS: Sedation and analgesia using dexmedetomidine combined with flurbiprofen axetil in addition to local anesthesia is a safe and effective approach in multiple complex teeth extraction.

Key words: Dexmedetomidine, Flurbiprofen axetil, Extraction of multiple complex teeth

CLC Number:

R782.05

SHAO Yun, SHENG Lu, HE Huan, LIU hui, LU Meng-meng, QI Ming. Evaluation of the application of dexmedetomidine combined with flurbiprofen axetil in extraction of multiple complex teeth under local anesthesia[J]. Shanghai Journal of Stomatology, 2021, 30(3): 302-305.

References

[1] 陈晖, 王晓波, 朱小茼. 口腔患者牙科焦虑状况的临床研究[J].中国健康心理学杂志, 2011, 19(4): 399-400.
[2] 唐彧,朱亚琴.口腔门诊成人牙科焦虑症调查分析[J].上海口腔医学, 2013, 22(6): 695-697.
[3] Dionne RA, Yagiela JA,Cote CJ, et al.Balancig efficacy and safety in the use of oral sedation in dental outpatients[J]. J Am Dent Assoc, 2006, 137(4): 502-513.
[4] Shepherd AR, Hill FJ.Orthodontic extractions: a comparative study of inhalation sedation and general anaesthesia[J]. Br Dent J, 2000, 188(6): 329-331.
[5] 周玭娉, 郁葱. 舒适化口腔医疗与患者医疗安全[J]. 中国实用口腔医学杂志, 2019, 12(11): 641-643.
[6] Yue HJ, Guilleminauilt C.Opioid medication and sleep-disordered breathing[J]. Med Clin North Am, 2010, 94(3): 435-446 .
[7] 赵燕, 高巨,林舜艳,等.右美托咪定术前滴鼻对全麻患儿术后行为改变的影响[J]. 临床麻醉学杂志, 2016, 32(3): 222-225 .
[8] White PF.The changing role of non-opioid analgesic techniques in the management of postoperative pain[J]. Anesth Analg, 2005, 101(5 Suppl): S5-22.
[9] 杨禄坤, 梁军, 张荣凯, 等. 氟比洛芬酯超前镇痛和术后镇痛预防下颌骨骨折术后躁动的研究[J]. 中国新药杂志, 2013, 22(10): 1202-1205.
[10] Wang Y, Zhang HB, Xia B, et al.Preemptive analgesic effects of flurbiprofen axetil in patients undergoing radical resection of esophageal carcinoma via the left thoracic approach[J]. Chin Med J (Engl), 2012, 125(4): 579-582.
[11] 吴新民, 薛张纲, 马虹, 等. 右美托咪定临床应用专家共识[J].临床麻醉学杂志, 2018, 34(8): 820-823.
[12] Jakob SM, Ruokonen E, GroundsRM, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials[J]. JAMA, 2012,307(11): 1151-1160.
[13] Linares Segovia B, Garcia Cuevas MA, Ramirez Casillas Il, et al.Pre-anesthetic medication with intranasal dexmedetomidine and oral midazolam as an anxiolytic. a clinical trial[J]. An Pediar(Barc), 2014, 81(4): 226-231.