Expression of hypoxia inducible factor-1alpha during mouse mandibular first molar eruption and its significance

doi:10.19439/j.sjos.2021.01.003

Abstract

Abstract: PURPOSE: To investigate the expression of hypoxia inducible factor-1alpha (HIF-1α) during the eruption of mouse lower first molar, and to explore the correlation between its expression and the activity of osteoclasts. METHODS: Mouse mandibles were dissected from mice at day 1.5 to 14.5 after birth. They were then serially sectioned and stained respectively using hemotoxylin, tartrate-resistant acid phosphatase (TRAP) staining, and immunohistochemical staining. SPSS 25.0 software package was used for data analysis. RESULTS: During the eruption of mouse lower first molar, the thickness of the crown alveolar bone gradually decreased, so did the number of osteoclasts and the expression of HIF-1α. CONCLUSIONS: During the eruption of mouse lower first molar, the less expression of HIF-1α, the fewer osteoclasts there were. HIF-1α may be involved in the eruption of mouse lower first molar by regulating the activity of osteoclasts.

Key words: Hypoxia inducible factor-1 alpha, Tooth eruption, Osteoclasts

CLC Number:

R782.1

HU Xiu, KANG Fei-wu. Expression of hypoxia inducible factor-1alpha during mouse mandibular first molar eruption and its significance[J]. Shanghai Journal of Stomatology, 2021, 30(1): 13-16.

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