上海口腔医学

上海口腔医学 ›› 2021, Vol. 30 ›› Issue (3): 312-315.doi: 10.19439/j.sjos.2021.03.018

• 论著 • 上一篇    下一篇

含乳化剂30和十二烷基硫酸钠表面活性剂的牙膏对口腔上皮完整性的影响

杨梅1, 赵海平1, 杨杰2   

  1. 1.青岛大学附属青岛市口腔医院 口腔综合科,山东 青岛 266001;
    2.潍坊医学院附属医院 口腔内科,山东 潍坊 261033
  • 收稿日期:2020-05-18 修回日期:2020-11-10 出版日期:2021-06-25 发布日期:2021-08-05
  • 通讯作者: 杨杰,E-mail：948316886@qq.com
  • 作者简介:杨梅（1983-）,女,硕士研究生,主治医师,E-mail：energy_mei@126.com
  • 基金资助:
    青岛市医疗卫生重点学科建设项目（2020-2022 中西医结合牙周黏膜病防治中心）

Effect of toothpaste containing emulsifier 30 and sodium lauryl sulfate surfactant on the integrity of oral epithelium

YANG Mei1, ZHAO Hai-ping1, YANG Jie2   

  1. 1. Department of General Dentistry, Qingdao Stomatological Hospital affiliated to Qingdao University. Qingdao 266001;
    2. Department of Stomatology, Affiliated Hospital of Weifang Medical University. Weifang 261033, Shandong Province, China
  • Received:2020-05-18 Revised:2020-11-10 Online:2021-06-25 Published:2021-08-05

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摘要： 目的: 评价含乳化剂30和十二烷基硫酸钠表面活性剂的牙膏对口腔上皮完整性的影响。方法: 将60例志愿者按随机数字法分为A、B 2组,每组各30例,A组给予含乳化剂30的牙膏,B组给予含十二烷基硫酸钠表面活性剂（sodium dodecyl sulfonate surfactant,SLS）的氟化物牙膏,均采用普通牙刷清洗口腔。利用自制口腔黏膜剥落评分表在患者使用产品前、使用产品后30 min、4 d评价口腔软组织剥落情况,以及2种牙膏菌斑及唾液中的氟浓度。采用SPSS 22.0软件包进行数据分析。结果: 使用后30 min、4 d,2组受试者口腔软组织剥落评分显著高于使用前（P<0.05）。A组使用后30 min,牙龈下、上、口顶、口腔软组织剥落总评分显著低于使用后4 d（P<0.05）,舌背软组织剥落评分无显著差异（P>0.05）。B组使用后30 min,牙龈下、上、舌背、腹、口腔软组织剥落总评分均显著高于使用后4 d,口顶、口腔软组织剥落评分显著低于使用后4 d（P<0.05）。使用后30 min,B组牙龈下、上、舌背、腹、口腔软组织剥落总评分均显著高于A组,口顶软组织剥落评分显著低于A组（P<0.05）。使用后4 d,B组牙龈下、上、舌腹、口腔软组织剥落总评分显著高于A组（P<0.05）。A、B组使用后4 d,口顶、舌背、口腔软组织剥落评分无显著差异（P>0.05）。使用后,2组受试者菌斑与唾液中氟浓度均显著高于使用前（P<0.05）。结论: 含乳化剂30和SLS表面活性剂的氟化物牙膏均存在一定口腔软组织剥落情况,但相比之下,含乳化剂30的氟化物牙膏对口腔软组织损伤更小。上述2种氟化物牙膏均可有效抑制菌斑细菌产酸,预防龋齿。

关键词: 含乳化剂30, 十二烷基硫酸钠, 牙膏, 口腔上皮, 完整性

Abstract: PURPOSE: To investigate the effect of toothpaste containing emulsifier 30 and sodium lauryl sulfate surfactant on the integrity of oral epithelium. METHODS: Sixty individuals equally divided into 2 groups by random number table methods. Group A received toothpaste containing emulsifier 30, while group B received fluoride toothpaste containing sodium lauryl sulfate (SLS) surfactant. The exfoliation of oral soft tissue was evaluated before, 30 minutes and 4 days after the test. The fluoride concentration in plaque and saliva was compared between the two groups. The data were processed with SPSS 22.0 software package. RESULTS: The scores of oral soft tissue exfoliation at 30 min and 4 d after the test were increased significantly (P<0.05). The scores of subgingival, supragingival, oral apex and oral soft tissue exfoliation of group A at 30 min after using the paste were significantly lower than those 4 days after using the paste(P<0.05), while no significant change was observed in the score of oral soft tissue exfoliation at the dorsal tongue(P>0.05). The total scores of subgingival, supragingival, dorsal tongue, ventral tongue and oral soft tissue exfoliation in group B 30 min after using the paste were significantly higher than those at 4 d after use, and the score of oral soft tissue exfoliation at oral apex was significantly lower than that at 4 d after use (P<0.05).The total scores of subgingival, supragingival, dorsal tongue, ventral tongue and oral soft tissue exfoliation in group B at 30 min after using the paste were significantly higher than those of group A, while the score of oral soft tissue exfoliation at oral apex was significantly lower than that of group A(P<0.05).The total scores of subgingival, supragingival, ventral tongue and oral soft tissue exfoliation in group B at 4 d after using the paste were significantly higher than those of group A(P<0.05). The scores of oral soft tissue exfoliation at oral apex and dorsal tongue at 4 d after use had no significant difference between the two groups (P>0.05). The fluoride concentration in plaque and saliva was increased significantly in both groups after test(P<0.05). CONCLUSIONS: Both fluoride toothpaste containing emulsifier 30 and SLS surfactant cause a certain degree of oral soft tissue exfoliation. In comparison, fluoride toothpaste containing emulsifier 30 has less oral soft tissue damage; moreover, the two fluoride toothpastes can effectively inhibit acid production of plaque bacteria and prevent occurrence of caries.

Key words: Emulsifier 30, Sodium lauryl sulfate, Toothpaste, Oral epithelium, Integrity

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