外用马来酸噻吗洛尔治疗婴幼儿血管瘤中国专家共识

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (6): 744-747.

外用马来酸噻吗洛尔治疗婴幼儿血管瘤中国专家共识

郑家伟¹, 王绪凯², 江成鸿³, 秦中平⁴, 范新东⁵, 李凯⁶, 杨耀武⁷, 霍然⁸, 刘少华⁹, 赵吉宏¹⁰, 汪小勇¹¹, 周德凯¹², 雷少榕¹³

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011;;
2.中国医科大学口腔医学院口腔颌面外科, 辽宁沈阳 110001;
3.福建医科大学附属协和医院整形外科,福建福州 350001;
4.山东省临沂市肿瘤医院省A级血管瘤特色专科 ,山东临沂 276001;
5.上海交通大学医学院附属第九人民医院介入科,上海 200011;
6.复旦大学附属儿科医院外科,上海 201102;
7.第四军医大学口腔医学院头颈肿瘤外科,陕西西安 710032;
8.山东省立医院烧伤整形美容外科,山东济南 250021;
9.山东大学齐鲁医院口腔颌面外科,山东济南 250012;
10.武汉大学口腔医学院口腔外科,湖北武汉 430079;
11.上海曹安医院血管瘤科,上海 201804;

收稿日期:2016-07-02 出版日期:2016-12-25 发布日期:2016-12-29
通讯作者: 王绪凯,E-mail：wangxukai757892@sina.com
作者简介:郑家伟(1964-),男,博士,教授,博士（后）研究生导师,E-mail:davidzhengjw@sjtu.edu.cn
基金资助:
国家自然科学基金（81070846,81470755）

Chinese expert consensus on the use of topical timolol maleate treatment of infantile hemangiomas

ZHENG Jia-wei¹,WANG Xu-kai², JIANG Cheng-hong³, QIN Zhong-ping⁴, FAN Xin-dong⁵, LI Kai⁶, YANG Yao-wu⁷, HUO Ran⁸, LIU Shao-hua⁹,ZHAO Ji-hong^{10^{, WANG Xiao-yong¹¹, ZHOU De-kai¹², LEI Shao-rong¹³}}

1.Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
2.Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University; Liaoning Institute of Dental Research. Shenyang 110001, Liaoning Province;
3.Department of Plastic and Reconstructive Surgery, Fujian Medical University, Union Hospital. Fuzhou 350001, Fujian Province;
4.Special Department of Hemangioma, Tumor Hospital of Linyi City. Linyi 276001, Shandong Province;
5.Department of Intervention Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
6.Department of Pediatric Surgery, Children's Hospital of Fudan University. Shanghai 201102;
7.Department of Head and Neck Tumor Surgery, School of Stomatology, The Fourth Military Medical University. Xi'an 710032, Shannxi Province;
8.Department of Aesthetic Plastic and Burn Surgery, Shandong Provincial Hospital, Shandong University. Jinan 250021,Shandong Province;
10.Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University. Jinan 250012,Shandong Province;
10.Department of Oral Surgery, School of Stomatology, Wuhan University. Wuhan 430079, Hubei Province;
11.Department of Infantile Hemangioma, Shanghai Cao'an Hospital. Shanghai 201804；12.Department of Infantile Hemangioma, Gastrointestinal and Neonatal Surgery, Children's Hospital of Chongqing Medical University. Chongqing 400014; 13.Department of Plastic and Esthetic Surgery, Xiangya Hospital Central South University. Changsha 410008, Hunan Province, China

Received:2016-07-02 Online:2016-12-25 Published:2016-12-29

摘要/Abstract

摘要： 非选择性β受体阻滞剂普萘洛尔已被美国FDA批准为治疗婴幼儿血管瘤的首选药物，并取得了显著效果。为减少口服普萘洛尔带来的全身不良反应，外用马来酸噻吗洛尔近年来正在被越来越多地作为全身用药以及众多观察等待患者的替代选择。但有关适应证，药物剂型、剂量、用药次数和方法、疗程，用药监测和不良反应等，仍无统一意见。为规范外用马来酸噻吗洛尔制剂在婴幼儿血管瘤治疗中的应用，避免过度治疗或治疗不足，减少并发症的发生，经国内多名不同专业从事婴幼儿血管瘤诊治的知名专家共同讨论，形成外用马来酸噻吗洛尔治疗婴幼儿血管瘤中国专家共识，供临床参照执行。

关键词: 噻吗洛尔, 婴幼儿血管瘤, 专家共识

Abstract: [Summary] Non-selective β-blocker propranolol has been proved by FDA as the first-line agent for infantile hemangioma (IH) with dramatic response. To reduce the side effects caused by systemic administration of propranolol, timolol maleate treatment has been increasingly used as an alternative to systemic β-blockers and watchful waiting for many IH patients in recent years. However, the appropriate indications, drug dosage, dosing regimen, time for initiation, optimal duration, monitoring for side effects still remains controversial. To standardize the use of topical timolol in treating IH, avoid overtreatment or under-treatment, as well as minimize complications, a Chinese expert consensus on the use of topical timolol treatment of IH has been approved and written by a multidisciplinary experts group based on an up-to-date literature review and repeated discussion, which can be used to reduce inappropriate variations in clinical practice and to promote the delivery of high quality, evidence-based health care for IH patients.

Key words: Timolol maleate, Infantile hemangioma, Expert consensus

中图分类号:

R739.8

郑家伟, 王绪凯, 江成鸿, 秦中平, 范新东, 李凯, 杨耀武, 霍然, 刘少华, 赵吉宏, 汪小勇, 周德凯, 雷少榕. 外用马来酸噻吗洛尔治疗婴幼儿血管瘤中国专家共识[J]. 上海口腔医学, 2016, 25(6): 744-747.

ZHENG Jia-wei,WANG Xu-kai, JIANG Cheng-hong, QIN Zhong-ping, FAN Xin-dong, LI Ka, YANG Yao-w, HUO Ran, LIU Shao-hua,ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LEI Shao-rong. Chinese expert consensus on the use of topical timolol maleate treatment of infantile hemangiomas[J]. Shanghai Journal of Stomatology, 2016, 25(6): 744-747.

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