他克莫司含漱液治疗糜烂型口腔扁平苔藓的随机单盲对照研究

上海口腔医学 ›› 2013, Vol. 22 ›› Issue (6): 708-710.

他克莫司含漱液治疗糜烂型口腔扁平苔藓的随机单盲对照研究

左雯鑫，李晓宇，蔡淦英，陈艳卿

(暨南大学第二临床医学院深圳市人民医院口腔医学中心，广东深圳 518020)

收稿日期:2013-05-20 修回日期:2013-07-15 出版日期:2013-04-12 发布日期:2013-04-12
通讯作者: 左雯鑫，Tel：0755-82284256，E-mail:zuowenxinsz@163.com
作者简介:左雯鑫(1975-)，女，硕士，副主任医师

A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus

ZUO Wen-xin, LI Xiao-yu, CAI Gan-ying, CHEN Yan-qing

Department of Stomatology, the Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital. Shenzhen 518020, Guangdong Province, China

Received:2013-05-20 Revised:2013-07-15 Online:2013-04-12 Published:2013-04-12

摘要/Abstract

摘要： 目的：评价他克莫司含漱液治疗糜烂型口腔扁平苔藓(OLP)的临床疗效。方法：采用随机单盲对照开放设计，将62例糜烂型OLP患者分为治疗组和对照组，治疗组采用他克莫司含漱液，对照组采用地塞米松含漱液，同时记录2组VAS和REU分值，使用SPSS17.0软件包对数据进行统计学分析，在用药4周和12周时分别评定疗效。结果：用药后4周和12周，2组VAS和REU分值均低于基线水平(P<0.01)，2组疗效差异无显著性(χ²=0.295、0.413，P>0.01)。用药后4周，治疗组REU分值低于对照组，差异显著(P<0.01)。结论：他克莫司含漱液治疗糜烂型OLP安全可靠且起效快，可在临床推广使用。

关键词: 他克莫司, 含漱液, 糜烂型口腔扁平苔藓

Abstract: PURPOSE: To evaluate the efficacy and safety of tacrolimus mouth rinse on the treatment of erosive and ulcerative oral lichen planus (OLP). METHODS: A randomized single-blind open trial of tacrolimus mouth rinse with dexamethasone as control was designed. The VAS and REU scoring system was utilized to compare the signs and symptoms. The scores and therapeutic effects were analyzed with SPSS 17.0 software package. RESULTS: There was no significant difference in effective rate between the treatment group and control group(χ²=0.295、0.413, P>0.01)at 4-week and 12-week after treatment. There was significant difference in REU scores between the 2 groups (P<0.01) 4 weeks after treatment. CONCLUSIONS: Tacrolimus mouth rinse effects quickly and is worthy of application in the treatment of erosive and ulcerative OLP.

Key words: Tacrolimus, Mouth rinse, Erosive oral lichen planus

中图分类号:

R781.5

左雯鑫, 李晓宇, 蔡淦英, 陈艳卿. 他克莫司含漱液治疗糜烂型口腔扁平苔藓的随机单盲对照研究[J]. 上海口腔医学, 2013, 22(6): 708-710.

ZUO Wen-xin, LI Xiao-yu, CAI Gan-ying, CHEN Yan-qing. A randomized single-blind controlled clinical trial of tacrolimus mouth rinse on erosive oral lichen planus[J]. Shanghai Journal of Stomatology, 2013, 22(6): 708-710.

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