上海口腔医学

上海口腔医学 ›› 2013, Vol. 22 ›› Issue (4): 428-431.

• 临床研究 • 上一篇    下一篇

交叉象限与上、下半口龈下刮治对龈沟液IL-27水平的影响

韩佳佳1，刘明朋2，靳赢1，刘迪昕1，方絮1，林晓萍1   

  1. (1.中国医科大学附属盛京医院 口腔科，辽宁 沈阳 110004；2.哈尔滨医科大学第一附属医院 口腔颌面外科，黑龙江 哈尔滨 150001)
  • 收稿日期:2013-01-04 修回日期:2013-01-30 出版日期:2013-08-10 发布日期:2013-08-10
  • 通讯作者: 林晓萍，Tel: 024-96615-61522,E-mail: Xiaoping_ba@yahoo.com
  • 作者简介:韩佳佳(1985-)，女，硕士研究生，医师，E-mail: hanjia1016@163.com
  • 基金资助:
    高等学校博士学科点专项科研基金 (20112104110013)；辽宁省科学技术计划项目(2012225015)

Comparison of the IL-27 level in gingival crevicular fluid of cross-quadrant and the upper and lower half-mouth subgingival scaling

HAN Jia-jia1, LIU Ming-peng2, JIN Ying1, LIU Di-xin1, FANG Xu1, LIN Xiao-ping1   

  1. 1.Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province; 2. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Harbin Medical University. Harbin 150001,Heilongjiang Province, China
  • Received:2013-01-04 Revised:2013-01-30 Online:2013-08-10 Published:2013-08-10
  • Supported by:
    Supported by Special Research Foundation of Ph.D. Program in University (20112104110013) and Science and Technology Program of Liaoning Province (2012225015).

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256

被引次数

3

摘要： 目的：检测慢性牙周炎患者采用不同方法进行牙周基础治疗前、后不同时期龈沟液中IL-27的浓度，探讨IL-27在牙周炎发病过程中所起的作用。方法：选择60例中、重度慢性牙周炎患者，随机分为A组(交叉象限刮治)和B组(上、下半口刮治)，每组30例，另选牙周健康者30例为C组(对照组)。A组和B组于基线和治疗后1、2、3周分别取样，记录每例患者的各项牙周临床指标。ELISA法检测龈沟液IL-27的浓度。应用SPSS 17.0软件包对数据进行统计学分析。结果：治疗后第2、3周，A、B 2组的PD、AL、BI、PLI均有明显改善，各分组象限与基线比较IL-27浓度均升高，而A组PD、AL、BI及IL-27浓度的变化较B组显著，差异有统计学意义；A组治疗后3周各分组象限IL-27浓度与C组无显著差异。IL-27浓度与PD、AL、BI、PLI呈负相关。结论：龈沟液IL-27可作为牙周病防治及疗效评估的潜在靶分子，交叉象限与上、下半口龈下刮治相比，短期效果更显著。

关键词: 牙周炎, 龈沟液, IL-27, 交叉象限龈下刮治

Abstract: PURPOSE: To investigate the changes of IL-27 in gingival crevicular fluid (GCF) before and after treatment with different methods for chronic periodontitis. METHODS: Sixty patients with moderate or severe chronic periodontitis were selected as study group to divide into group A (cross-quadrant) and group B (upper and lower half-mouth) randomly. Another 30 healthy people were selected as group C. Gingival crevicular fluid of group A and B were collected at baseline and each week during treatment. At the same time, the clinical parameters including PD, AL, BI and PLI were recorded. And the levels of IL-27 in GCF were measured by ELISA. SPSS 17.0 software package was used for statistical analysis. RESULTS: The levels of IL-27 in GCF 2 and 3 weeks after treatment were higher in study group compared with those at baseline, while PD, AL, BI and PLI showed significant reduction. The changes except PLI in group A was more obvious than group B, which had a significant difference. After three-week treatment, IL-27 in group A had no remarkable difference compared with group C. There were significantly negative correlation between PD, AL, BI, PLI and IL-27. CONCLUSIONS: IL-27 in GCF can be considered as a potential target for prevention and treatment of chronic periodontitis. Compared with the upper and lower half-mouth subgingival scaling, cross-quadrant has more pronounced short-term effect.

Key words: Periodontitis, Gingival crevicular fluid, IL-27, Cross-quadrant subgingival scaling

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