上海口腔医学

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (3): 324-327.doi: 10.19439/j.sjos.2017.03.021

• 论著 • 上一篇    下一篇

口腔种植修复在牙列缺失患者中的应用效果及对龈沟液中TNF-α、IL-6、IL-8的影响

罗蓉, 罗军, 夏罗英   

  1. 广东省广州市花都区人民医院 口腔科,广东 广州 510800
  • 收稿日期:2017-03-20 修回日期:2017-04-26 出版日期:2017-06-25 发布日期:2017-07-05
  • 通讯作者: 罗蓉,E-mail: jam_crter@163.com
  • 作者简介:罗蓉（1970-）,女,硕士,主治医师

Effects of oral implant prosthesis in patients with missing teeth and influence on gingival sulcus TNF-α, IL-6 and IL-8

LUO Rong, LUO Jun, XIA Luo-ying   

  1. Department of Stomatology, People's Hospital of Huadu District,Guangzhou City. Guangzhou 510800, Guangdong Province, China
  • Received:2017-03-20 Revised:2017-04-26 Online:2017-06-25 Published:2017-07-05

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摘要： 目的探讨口腔种植修复在牙列缺失患者中的应用效果及对龈沟液中肿瘤坏死因子α（TNF-α）、白细胞介素6、8（IL-6、IL-8）的影响。方法选择2014年10月—2016年10月于我院就诊的94例牙列缺失患者,按治疗方式分组,各47例,对照组采用常规修复,实验组采用口腔种植修复,比较2组的临床疗效,TNF-α、IL-6、IL-8,牙龈状态、牙功能,以及并发症发生情况。采用SPSS8.0软件包对数据进行统计学处理。结果实验组总有效率显著高于对照组(95.74%∶80.85%,P<0.05）。实验组TNF-α、IL-6、IL-8[（3.55±0.42）μg/L、（25.90±3.24）μg/L、（69.34±8.65）μg/L]显著低于对照组[（4.69±0.58）μg/L、（41.37±5.19）μg/L、（108.72±13.56）μg/L]（P<0.05）。实验组牙龈状态、牙功能均优于对照组,且并发症率显著少于对照组（P<0.05）。结论口腔种植修复在牙列缺失患者中的应用效果肯定,可抑制龈沟液中TNF-α、IL-6、IL-8的表达,减轻局部炎症反应,改善牙的功能。

关键词: 牙列缺失, 口腔种植修复, 肿瘤坏死因子α, 白细胞介素6, 白细胞介素8

Abstract: PURPOSE: To evaluate effects of oral implant prosthesis in patients with missing teeth and influence on gingival sulcus TNF-α, IL-6 and IL-8. METHODS: Ninety four cases with tooth missing from October 2014 to October 2016 were divided into 2 groups, with 47 in each group. Patients in the control group were treated with conventional restoration, experimental group were treated with oral implantation. The clinical effects, levels of TNF-α, IL-6 and IL-8, gingival state, dental functions, and complications between the two groups were compared. Statistical analysis was performed using SPSS8.0 software package. RESULTS: The total effective rate of the experimental group was significantly higher than the control group (95.74% vs 80.85%, P<0.05). TNF-α, IL-6 and IL-8 of the experimental group was significantly lower than the control group (3.55±0.42) μg/L, (25.90±3.24) μg/L, (69.34±8.65) μg/L vs (4.69±0.58) μg/L, (41.37±5.19) μg/L, (108.72±13.56) μg/L (P<0.05). The gingival state, dental functions of the experimental group were significantly better than the control group, and the complications was significantly less than the control group (P<0.05). CONCLUSIONS: The application of oral implant in dentition missing patients is satisfactory, which can inhibit the expression of TNF-α, IL-6 and IL-8, reduce local inflammatory response and improve dental function.

Key words: Tooth missing, Oral implant prosthesis, Tumor necrosis factor-α, Interleukin 6, Interleukin 8

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